Review on plant antimicrobials: a mechanistic viewpoint

Tomatidine Is a Lead Antibiotic Molecule That Targets Staphylococcus aureus ATP Synthase Subunit C

(2018) Maxime Lamontagne Boulet et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Coumarin: a novel player in microbial quorum sensing and biofilm formation inhibition

(2018) F. Jerry Reen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthesis and Biological Evaluation of Coumarins Derivatives as Potential Inhibitors of the Production of Pseudomonas aeruginosa Virulence Factor Pyocyanin

(2018) Luana da S.M. Forezi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Potential effect of 2-isopropyl-5-methylphenol (thymol) alone and in combination with fluconazole against clinical isolates of Candida albicans , C. glabrata and C. krusei

(2018) A. Sharifzadeh et al.   JOURNAL DE MYCOLOGIE MEDICALE

Synergy of clavine alkaloid ‘chanoclavine’ with tetracycline against multi-drug-resistant E. coli

(2018) Gaurav Raj Dwivedi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Natural and hemi-synthetic pentacyclic triterpenes as antimicrobials and resistance modifying agents against Staphylococcus aureus: a review

(2018) Lucy Catteau et al.   PHYTOCHEMISTRY REVIEWS

Carvacrol and its derivatives as antibacterial agents

(2018) Lisa Marinelli et al.   PHYTOCHEMISTRY REVIEWS

Tomatidine and analog FC04–100 possess bactericidal activities against Listeria, Bacillus and Staphylococcus spp

(2018) Isabelle Guay et al.   BMC Pharmacology & Toxicology

Coumarin Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-di-GMP Levels

(2018) Yunhui Zhang et al.   Frontiers in Microbiology

Comprehensive review of antimicrobial activities of plant flavonoids

(2018) Ireneusz Górniak et al.   PHYTOCHEMISTRY REVIEWS

Antibacterial activity of flavonoids and their structure-activity relationship: An update review

(2018) Faegheh Farhadi et al.   PHYTOTHERAPY RESEARCH

Ferula species: A rich source of antimicrobial compounds

(2018) Zahra Boghrati et al.   Journal of Herbal Medicine

Natural isoflavone biochanin A as a template for the design of new and potent 3-phenylquinolone efflux inhibitors against Mycobacterium avium

(2017) Rolando Cannalire et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antibacterial activity of N -methylbenzofuro[3,2- b ]quinoline and N -methylbenzoindolo[3,2- b ]-quinoline derivatives and study of their mode of action

(2017) Ning Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Solasodine-3- O -β- d -glucopyranoside kills Candida albicans by disrupting the intracellular vacuole

(2017) Wenqiang Chang et al.   FOOD AND CHEMICAL TOXICOLOGY

Identification and biological activity of the volatile compounds of Glycyrrhiza triphylla Fisch. & C.A.Mey

(2017) Abolfazl Shakeri et al.   MICROBIAL PATHOGENESIS

Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity

(2017) Ramona Barbieri et al.   MICROBIOLOGICAL RESEARCH

Diallylthiosulfinate (Allicin), a Volatile Antimicrobial from Garlic (Allium sativum), Kills Human Lung Pathogenic Bacteria, Including MDR Strains, as a Vapor

(2017) Jana Reiter et al.   MOLECULES

Efflux pump inhibitory activity of flavonoids isolated from Alpinia calcarata against methicillin-resistant Staphylococcus aureus

(2016) Harmandeep K. Randhawa et al.   BIOLOGIA

Modulating antibiotic activity towards respiratory bacterial pathogens by co-medications: a multi-target approach

(2016) Nathalie M. Vandevelde et al.   DRUG DISCOVERY TODAY

Isolation and identification of an antibacterial compound from Diplotaxis harra (Forssk.) Boiss

(2016) Roudaina Benzekri et al.   INDUSTRIAL CROPS AND PRODUCTS

Anti-Campylobacteractivity of resveratrol and an extract from waste Pinot noir grape skins and seeds, and resistance ofCamp. jejuniplanktonic and biofilm cells, mediated via the CmeABC efflux pump

(2016) A. Klančnik et al.   JOURNAL OF APPLIED MICROBIOLOGY

Holarrhena antidysentericaExtract and Its Steroidal Alkaloid, Conessine, as Resistance-Modifying Agents Against Extensively Drug-ResistantAcinetobacter baumannii

(2016) Thanyaluck Siriyong et al.   Microbial Drug Resistance

Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them

(2016) Bahman Khameneh et al.   MICROBIAL PATHOGENESIS

Antibacterial and efflux pump inhibitors of thymol and carvacrol against food-borne pathogens

(2016) Hanene Miladi et al.   MICROBIAL PATHOGENESIS

Antibacterial Activity and Membrane-Disruptive Mechanism of 3-p-trans-Coumaroyl-2-hydroxyquinic Acid, a Novel Phenolic Compound from Pine Needles of Cedrus deodara, against Staphylococcus aureus

(2016) Yanping Wu et al.   MOLECULES

Natural Products as a Source for Novel Antibiotics

(2016) Mark G. Moloney   TRENDS IN PHARMACOLOGICAL SCIENCES

Deciphering the role of coumarin as a novel quorum sensing inhibitor suppressing virulence phenotypes in bacterial pathogens

(2015) José A. Gutiérrez-Barranquero et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Studies of the interactions of ursane-type bioactive terpenes with the model of Escherichia coli inner membrane—Langmuir monolayer approach

(2015) Marcin Broniatowski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action

(2015) Kunal Patel et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

New promising β-lactamase inhibitors for clinical use

(2015) I. Olsen   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Effect of carvacrol and thymol onSalmonellaspp. biofilms on polypropylene

(2015) Viviane C. S. Amaral et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Antagonistic effects of indoloquinazoline alkaloids on antimycobacterial activity of evocarpine

(2015) C. Hochfellner et al.   JOURNAL OF APPLIED MICROBIOLOGY

Therapeutic Potential of Steroidal Alkaloids in Cancer and Other Diseases

(2015) Qi-Wei Jiang et al.   MEDICINAL RESEARCH REVIEWS

The antibacterial properties of isothiocyanates

(2015) Virginie Dufour et al.   MICROBIOLOGY-SGM

Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?

(2015) David Brown   NATURE REVIEWS DRUG DISCOVERY

The roles ofCDR1,CDR2,andMDR1in kaempferol-induced suppression with fluconazole-resistantCandida albicans

(2015) Jing Shao et al.   PHARMACEUTICAL BIOLOGY

Pharmacological synergism of bee venom and melittin with antibiotics and plant secondary metabolites against multi-drug resistant microbial pathogens

(2015) Issam AL-Ani et al.   PHYTOMEDICINE

Cytotoxicity of the indole alkaloid reserpine from Rauwolfia serpentina against drug-resistant tumor cells

(2015) Sara A.A. Abdelfatah et al.   PHYTOMEDICINE

Multidrug evolutionary strategies to reverse antibiotic resistance

(2015) M. Baym et al.   SCIENCE

Prevalence of Genes of OXA-23 Carbapenemase and AdeABC Efflux Pump Associated with Multidrug Resistance of Acinetobacter baumannii Isolates in the ICU of a Comprehensive Hospital of Northwestern China

(2015) Wei Jia et al.   International Journal of Environmental Research and Public Health

Resistance of Stenotrophomonas maltophilia to Fluoroquinolones: Prevalence in a University Hospital and Possible Mechanisms

(2015) Wei Jia et al.   International Journal of Environmental Research and Public Health

Glucosinolate-derived isothiocyanates impact mitochondrial function in fungal cells and elicit an oxidative stress response necessary for growth recovery

(2015) Benoit Calmes et al.   Frontiers in Plant Science

Eugenol: A Phyto-Compound Effective against Methicillin-Resistant and Methicillin-Sensitive Staphylococcus aureus Clinical Strain Biofilms

(2015) Mukesh Kumar Yadav et al.   PLoS One

Bactericidal Activity of Curcumin I Is Associated with Damaging of Bacterial Membrane

(2015) Poonam Tyagi et al.   PLoS One

A Mass Spectrometry-Based Assay for Improved Quantitative Measurements of Efflux Pump Inhibition

(2015) Adam R. Brown et al.   PLoS One

In vitro activity of curcumin in combination with epigallocatechin gallate (EGCG) versus multidrug-resistant Acinetobacter baumannii

(2014) Jonathan W Betts et al.   BMC MICROBIOLOGY

Beta-Lactam Antibiotics Induce a Lethal Malfunctioning of the Bacterial Cell Wall Synthesis Machinery

(2014) Hongbaek Cho et al.   CELL

Investigation of the antibacterial activity and efflux pump inhibitory effect of co-loaded piperine and gentamicin nanoliposomes in methicillin-resistantStaphylococcus aureus

(2014) Bahman Khameneh et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Design, synthesis, and evaluation of novel fluoroquinolone–flavonoid hybrids as potent antibiotics against drug-resistant microorganisms

(2014) Zhu-Ping Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Natural products as antimicrobial agents

(2014) Rabin Gyawali et al.   FOOD CONTROL

The Mechanism of Antimicrobial Activity of Sophoraflavanone B Against Methicillin-Resistant Staphylococcus aureus

(2014) Su-Hyun Mun et al.   Foodborne Pathogens and Disease

Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities

(2014) T.P. Tim Cushnie et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Resveratrol against Arcobacter butzleri and Arcobacter cryaerophilus: Activity and effect on cellular functions

(2014) Susana Ferreira et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Antimicrobial Activity of Isothiocyanates from Cruciferous Plants against Methicillin-Resistant Staphylococcus aureus (MRSA)

(2014) Carla Dias et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antifungal efficacy of thymol, carvacrol, eugenol and menthol as alternative agents to control the growth of food-relevant fungi

(2014) S. Abbaszadeh et al.   JOURNAL DE MYCOLOGIE MEDICALE

Haloemodin as Novel Antibacterial Agent Inhibiting DNA Gyrase and Bacterial Topoisomerase I

(2014) Feixia Duan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Compounds from Allium species with cytotoxic and antimicrobial activity

(2014) Virginia Lanzotti et al.   PHYTOCHEMISTRY REVIEWS

Inhibitory Activity of the Isoflavone Biochanin A on Intracellular Bacteria of Genus Chlamydia and Initial Development of a Buccal Formulation

(2014) Leena Hanski et al.   PLoS One

Thymol disrupts the membrane integrity of Salmonella ser. typhimurium in vitro and recovers infected macrophages from oxidative stress in an ex vivo model

(2014) Anil Kumar Chauhan et al.   RESEARCH IN MICROBIOLOGY

Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates

(2013) Jed W. Fahey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A structure–activity relationship study of flavonoids as inhibitors of E. coli by membrane interaction effect

(2013) Ting Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Antimicrobial Activity of Isothiocyanates （ITCs） Extracted from Horseradish （Armoracia rusticana） Root against Oral Microorganisms

(2013) HO-WON PARK et al.   BIOCONTROL SCIENCE

Antibacterial and Synergy of Clavine Alkaloid Lysergol and its Derivatives Against Nalidixic Acid-ResistantEscherichia coli

(2013) Anupam Maurya et al.   Chemical Biology & Drug Design

Synthesis, structure–activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors

(2013) Zhu-Ping Xiao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

NorA efflux pump inhibitory activity of coumarins from Mesua ferrea

(2013) Somendu K. Roy et al.   FITOTERAPIA

Ungeremine and Its Hemisynthesized Analogues as Bactericides against Flavobacterium columnare

(2013) Kevin K. Schrader et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Identification of Essential Oil Components ofFerula badrakemaFruits by GC-MS and13C-NMR Methods and Evaluation of its Antimicrobial Activity

(2013) Javad Asili et al.   Journal of Essential Oil Bearing Plants

Allium ursinum: botanical, phytochemical and pharmacological overview

(2013) Danuta Sobolewska et al.   PHYTOCHEMISTRY REVIEWS

Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles

(2012) Jes Gitz Holler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Microbial Efflux Pump Inhibition: Tactics and Strategies

(2012) George P. Tegos et al.   CURRENT PHARMACEUTICAL DESIGN

Novel inhibitory activity of the Staphylococcus aureus NorA efflux pump by a kaempferol rhamnoside isolated from Persea lingue Nees

(2012) J. G. Holler et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

High Content of Polysulphides in the Volatile Oil ofFerula latisectaRech. F. et Aell. Fruits and Antimicrobial Activity of the Oil

(2012) Mehrdad Iranshahi et al.   JOURNAL OF ESSENTIAL OIL RESEARCH

Antibacterial Activities AgainstStaphylococcus aureusof Terpene Alcohols With Aliphatic Carbon Chains

(2012) Naoko Togashi et al.   JOURNAL OF ESSENTIAL OIL RESEARCH

Antimicrobial Activity of Phenolics and Glucosinolate Hydrolysis Products and their Synergy with Streptomycin against Pathogenic Bacteria

(2012) Maria Saavedra et al.   Medicinal Chemistry

Terpene Biosynthesis: Modularity Rules

(2011) Eric Oldfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases

(2011) Laura Casu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Study of the Chemical Composition and Antimicrobial Activities of Ethanolic Extracts from Roots of Scutellaria baicalensis Georgi

(2011) Yingjian Lu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Tomatidine acts in synergy with aminoglycoside antibiotics against multiresistant Staphylococcus aureus and prevents virulence gene expression

(2011) G. Mitchell et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase

(2011) Ben C.L. Chan et al.   JOURNAL OF ETHNOPHARMACOLOGY

The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus

(2011) Brice W Obiang-Obounou et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Antimicrobial activity of the methanolic bark extract ofHolarrhena pubescens(Buch. Ham), its fractions and the pure compound conessine

(2011) Bina S. Siddiqui et al.   NATURAL PRODUCT RESEARCH

Benzyl Isothiocyanate, a Major Component from the Roots of Salvadora Persica Is Highly Active against Gram-Negative Bacteria

(2011) Abier Sofrata et al.   PLoS One

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(2011) Bibi Sedigheh Fazly Bazzaz et al.   SCIENCEASIA

Effect of galbanic acid, a sesquiterpene coumarin from Ferula szowitsiana, as an inhibitor of efflux mechanism in resistant clinical isolates of Staphylococcus aureus

(2010) Bibi Sedigheh Fazly Bazzaz et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Use of natural antimicrobials to increase antibiotic susceptibility of drug resistant bacteria

(2010) Kavitha Palaniappan et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Analysis and Anti-Helicobacter Activity of Sulforaphane and Related Compounds Present in Broccoli (Brassica oleracea L.) Sprouts

(2010) Joon-Kwan Moon et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

New insights into the antibacterial mechanism of action of squalamine

(2010) K. Alhanout et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Evaluation of Antibacterial Activity of 3-Butenyl, 4-Pentenyl, 2-Phenylethyl, and Benzyl Isothiocyanate in Brassica Vegetables

(2010) Miran Jang et al.   JOURNAL OF FOOD SCIENCE

Genetic Evidence for Inhibition of Bacterial Division Protein FtsZ by Berberine

(2010) Jaroslaw M. Boberek et al.   PLoS One

The Structure and Pharmacological Functions of Coumarins and Their Derivatives

(2009) L. Wu et al.   CURRENT MEDICINAL CHEMISTRY

Isothiocyanate Profile and Selective Antibacterial Activity of Root, Stem, and Leaf Extracts Derived from Raphanus sativus L.

(2009) Syed Sultan Beevi et al.   Foodborne Pathogens and Disease

A study of the antimicrobial activity of selected naturally occurring and synthetic coumarins

(2009) T. Smyth et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Cell membrane damage induced by phenolic acids on wine lactic acid bacteria

(2009) F.M. Campos et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Enzymatic inhibition by allyl isothiocyanate and factors affecting its antimicrobial action against Escherichia coli O157:H7

(2009) Fernando B. Luciano et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

An oldie but a goodie – cell wall biosynthesis as antibiotic target pathway

(2009) Tanja Schneider et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

The antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis products on bacteria isolated from the human intestinal tract

(2009) A. Aires et al.   JOURNAL OF APPLIED MICROBIOLOGY

Screening of Flavonoids as Candidate Antibiotics againstEnterococcus faecalis

(2009) Ki-Woong Jeong et al.   JOURNAL OF NATURAL PRODUCTS

Mechanisms of Resistance: Useful Tool to Design Antibacterial Agents for Drug - Resistant Bacteria

(2009) J. Savjani et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Antimicrobial and Antioxidant Activities of Coumarins from the Roots of Ferulago campestris (Apiaceae)

(2009) Adriana Basile et al.   MOLECULES

Biological Activities of Novel Gyrase Inhibitors of the Aminocoumarin Class

(2008) C. Anderle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Berberine Targets Assembly of Escherichia coli Cell Division Protein FtsZ†

(2008) Prerna N. Domadia et al.   BIOCHEMISTRY

In Vitro Synergism of Fluconazole and Baicalein against Clinical Isolates of Candida albicans Resistant to Fluconazole

(2008) Shan Huang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Antimicrobial properties of selected essential oils in vapour phase against foodborne bacteria

(2008) Lenka Nedorostova et al.   FOOD CONTROL

d-Alanine:d-alanine ligase as a new target for the flavonoids quercetin and apigenin

(2008) Dalei Wu et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus

(2008) A. Kumar et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis

(2008) D. Lechner et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

(2008) Jean-Marie Pagès et al.   NATURE REVIEWS MICROBIOLOGY

Sortase as a Target of Anti-Infective Therapy

(2008) A. W. Maresso et al.   PHARMACOLOGICAL REVIEWS

Three flavonoids targeting the β-hydroxyacyl-acyl carrier protein dehydratase fromHelicobacter pylori: Crystal structure characterization with enzymatic inhibition assay

(2008) Liang Zhang et al.   PROTEIN SCIENCE

Antimicrobial activity of the methanolic extract and compounds from Teclea afzelii (Rutaceae)

(2008) V. Kuete et al.   SOUTH AFRICAN JOURNAL OF BOTANY

In vitro bactericidal activity of allicin combined with cefoperazone, tobramycin and ciprofloxacin

(2007) Yun Cai et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS