Comprehensive review of antimicrobial activities of plant flavonoids

Bacterial biofilm and associated infections

(2018) Muhsin Jamal et al.   Journal of the Chinese Medical Association

Flavonoids SuppressPseudomonas aeruginosaVirulence through Allosteric Inhibition of Quorum-sensing Receptors

(2017) Jon E. Paczkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multitargeted Flavonoid Inhibition of the Pathogenic Bacterium Staphylococcus aureus: A Proteomic Characterization

(2017) Wael A. Elmasri et al.   JOURNAL OF PROTEOME RESEARCH

Inhibitory effects of flavonoids on biofilm formation by Staphylococcus aureus that overexpresses efflux protein genes

(2017) Laênia Angélica Andrade Lopes et al.   MICROBIAL PATHOGENESIS

The Correlation between Chemical Structures and Antioxidant, Prooxidant, and Antitrypanosomatid Properties of Flavonoids

(2017) João Luiz Baldim et al.   Oxidative Medicine and Cellular Longevity

The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria

(2017) Heleen Van Acker et al.   TRENDS IN MICROBIOLOGY

Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action

(2017) Ranita Roy et al.   Virulence

Dimethyl Sulfoxide Protects Escherichia coli from Rapid Antimicrobial-Mediated Killing

(2016) Hongfei Mi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selective toxicity of Catechin—a natural flavonoid towards bacteria

(2016) Aafreen Fathima et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Pharmacologically active flavonoids from the anticancer, antioxidant and antimicrobial extracts of Cassia angustifolia Vahl

(2016) Shabina Ishtiaq Ahmed et al.   BMC Complementary and Alternative Medicine

Structural analysis of dihydrofolate reductases enables rationalization of antifolate binding affinities and suggests repurposing possibilities

(2016) Amrisha Bhosle et al.   FEBS Journal

Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011–2014

(2016) Lindsey M. Weiner et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Quercetin is an effective inhibitor of quorum sensing, biofilm formation and virulence factors inPseudomonas aeruginosa

(2016) J. Ouyang et al.   JOURNAL OF APPLIED MICROBIOLOGY

Cytotoxic, antibacterial and antibiofilm activities of aqueous extracts of leaves and flavonoids occurring in Kalanchoe pinnata (Lam.) Pers.

(2016) José de Souza Barboza Thiago et al.   Journal of Medicinal Plants Research

Inhibition of gingipains andPorphyromonas gingivalisgrowth and biofilm formation by prenyl flavonoids

(2016) T. Kariu et al.   JOURNAL OF PERIODONTAL RESEARCH

Experimental Modeling of Flavonoid–Biomembrane Interactions

(2016) Didem Sanver et al.   LANGMUIR

C-Geranylated flavonoids fromPaulownia tomentosafruits with antimicrobial potential and synergistic activity with antibiotics

(2016) Alice Navrátilová et al.   PHARMACEUTICAL BIOLOGY

Mass spectrometric imaging of flavonoid glycosides and biflavonoids in Ginkgo biloba L.

(2016) Sebastian Beck et al.   PHYTOCHEMISTRY

Role of Multicellular Aggregates in Biofilm Formation

(2016) Kasper N. Kragh et al.   mBio

3D-QSAR and docking studies of flavonoids as potent Escherichia coli inhibitors

(2016) Yajing Fang et al.   Scientific Reports

The Antibacterial Activity of Coriolus versicolor Methanol Extract and Its Effect on Ultrastructural Changes of Staphylococcus aureus and Salmonella Enteritidis

(2016) Danka Matijašević et al.   Frontiers in Microbiology

Safety and efficacy of cocoa flavanol intake in healthy adults: a randomized, controlled, double-masked trial

(2015) Javier I Ottaviani et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Inhibition of Aminoglycoside Acetyltransferase Resistance Enzymes by Metal Salts

(2015) Yijia Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects of Epigallocatechin gallate against Enterococcus faecalis biofilm and virulence

(2015) Pei Lee et al.   ARCHIVES OF ORAL BIOLOGY

Antimicrobial and antioxidant flavonoids from the leaves of Oncoba spinosa Forssk. (Salicaceae)

(2015) Marie Geneviève Djouossi et al.   BMC Complementary and Alternative Medicine

Structures of multidrug and toxic compound extrusion transporters and their mechanistic implications

(2015) Min Lu   Channels

Synergy and Mode of Action of Ceftazidime plus Quercetin or Luteolin onStreptococcus pyogenes

(2015) Supatcharee Siriwong et al.   Evidence-based Complementary and Alternative Medicine

The safety of green tea extract supplementation in postmenopausal women at risk for breast cancer: results of the Minnesota Green Tea Trial

(2015) Allison M. Dostal et al.   FOOD AND CHEMICAL TOXICOLOGY

In vitroPotential Effect of Morin in the Combination with β-Lactam Antibiotics Against Methicillin-ResistantStaphylococcus aureus

(2015) Su-Hyun Mun et al.   Foodborne Pathogens and Disease

Synergy between baicalein and penicillins against penicillinase-producing Staphylococcus aureus

(2015) Minyi Qian et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Phenolic Phytoalexins in Rice: Biological Functions and Biosynthesis

(2015) Man-Ho Cho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bacterial antimicrobial metal ion resistance

(2015) Jon L. Hobman et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Membrane Interactions of Phytochemicals as Their Molecular Mechanism Applicable to the Discovery of Drug Leads from Plants

(2015) Hironori Tsuchiya   MOLECULES

Secondary metabolites in plant innate immunity: conserved function of divergent chemicals

(2015) Anna Piasecka et al.   NEW PHYTOLOGIST

Isoflavones Reduce Copper with Minimal Impact on IronIn Vitro

(2015) Jana Karlíčková et al.   Oxidative Medicine and Cellular Longevity

Antimicrobial activity of pomegranate fruit constituents against drug-resistantMycobacterium tuberculosisandβ-lactamase producingKlebsiella pneumoniae

(2015) Diganta Dey et al.   PHARMACEUTICAL BIOLOGY

Antifolate Activity of Plant Polyphenols againstMycobacterium tuberculosis

(2015) Archana Raju et al.   PHYTOTHERAPY RESEARCH

Dual role of pinostrobin-a flavonoid nutraceutical as an efflux pump inhibitor and antibiofilm agent to mitigate food borne pathogens

(2015) Lowrence Rene Christena et al.   RSC Advances

Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa

(2015) Robert K Ulrey et al.   BMC Complementary and Alternative Medicine

Synthetic 3-Arylidenefl avanones as Inhibitors of the Initial Stages of Biofilm Formation by Staphylococcus aureus and Enterococcus faecalis

(2015) Aleksandra Budzyńska et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Antibacterial and Anti-Biofilm Activity of Flavonoids and Triterpenes Isolated from The Extracts of Ficus Sansibarica Warb. Subsp. Sansibarica (Moraceae) Extracts

(2014) GV Awolola et al.   African Journal of Traditional Complementary and Alternative Medicines

Mechanism of Quinolone Action and Resistance

(2014) Katie J. Aldred et al.   BIOCHEMISTRY

Antimicrobial activity, toxicity and selectivity index of two biflavonoids and a flavone isolated from Podocarpus henkelii (Podocarpaceae) leaves

(2014) Victor P Bagla et al.   BMC Complementary and Alternative Medicine

Docking analysis insights quercetin can be a non-antibiotic adjuvant by inhibiting Mmr drug efflux pump inMycobacteriumsp. and its homologue EmrE inEscherichia coli

(2014) Balasubramanian Suriyanarayanan et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Mechanisms of vancomycin resistance in Staphylococcus aureus

(2014) Susana Gardete et al.   JOURNAL OF CLINICAL INVESTIGATION

Flavonoids with antimicrobial activity from the stem bark ofCommiphora pedunculata(Kotschy & Peyr.) Engl.

(2014) Nasir Tajuddeen et al.   NATURAL PRODUCT RESEARCH

Identification of Natural Compound Inhibitors for Multidrug Efflux Pumps of Escherichia coli and Pseudomonas aeruginosa Using In Silico High-Throughput Virtual Screening and In Vitro Validation

(2014) Vasudevan Aparna et al.   PLoS One

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro evaluation of copper-chelating properties of flavonoids

(2014) Michal Říha et al.   RSC Advances

The antimicrobial possibilities of green tea

(2014) Wanda C. Reygaert   Frontiers in Microbiology

Multiple Plantago species (Plantaginaceae) modify floral reflectance and color in response to thermal change

(2013) Erin R. Anderson et al.   AMERICAN JOURNAL OF BOTANY

Linezolid-resistant clinical isolates of enterococci and Staphylococcus cohnii from a multicentre study in China: molecular epidemiology and resistance mechanisms

(2013) Hongbin Chen et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Hospital-associated MRSA and antibiotic resistance—What have we learned from genomics?

(2013) Jodi A. Lindsay   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Flavonoids as Antioxidants and Developmental Regulators: Relative Significance in Plants and Humans

(2013) Cecilia Brunetti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structure–Activity Relationship of Flavonoids on Their Anti-Escherichia coli Activity and Inhibition of DNA Gyrase

(2013) Ting Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Subinhibitory concentrations of pinocembrin exert anti-Staphylococcus aureusactivity by reducingα-toxin expression

(2013) L.W. Soromou et al.   JOURNAL OF APPLIED MICROBIOLOGY

The ABCD’s of β-lactamase nomenclature

(2013) Karen Bush   JOURNAL OF INFECTION AND CHEMOTHERAPY

Discovery of antibiotic adjuvants

(2013) Maya A Farha et al.   NATURE BIOTECHNOLOGY

Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production

(2013) Mark P Brynildsen et al.   NATURE BIOTECHNOLOGY

Eriosema chinense: A rich source of antimicrobial and antioxidant flavonoids

(2013) Sanit Thongnest et al.   PHYTOCHEMISTRY

Flavonoids fromSophora moorcroftianaand their Synergistic Antibacterial Effects on MRSA

(2013) Shuang-Ying Wang et al.   PHYTOTHERAPY RESEARCH

Sarothrin from Alkanna orientalis Is an Antimicrobial Agent and Efflux Pump Inhibitor

(2013) Jessica Bame et al.   PLANTA MEDICA

Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins

(2013) K. A. Hassan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fe-S Cluster Biosynthesis Controls Uptake of Aminoglycosides in a ROS-Less Death Pathway

(2013) B. Ezraty et al.   SCIENCE

Pollinator-mediated evolution of floral signals

(2013) Florian P. Schiestl et al.   TRENDS IN ECOLOGY & EVOLUTION

Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)

(2013) Wen Li et al.   Nature Communications

Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm

(2013) Sara M. Soto   Virulence

Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities

(2013) Azhar Rasul et al.   Biomed Research International

Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance

(2012) L. Fernandez et al.   CLINICAL MICROBIOLOGY REVIEWS

Flavonoids Acting on DNA Topoisomerases: Recent Advances and Future Perspectives in Cancer Therapy

(2012) P. Russo et al.   CURRENT MEDICINAL CHEMISTRY

The Potential of Secondary Metabolites from Plants as Drugs or Leads Against Protozoan Neglected Diseases - Part II

(2012) T.J. Schmidt et al.   CURRENT MEDICINAL CHEMISTRY

2012 and beyond: potential for the start of a second pre-antibiotic era?

(2012) P. C. Appelbaum   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm

(2012) S. Baugh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Inhibitory effect of grape seed extract (GSE) on cariogenic bacteria

(2012) Hala El-Adawi   Journal of Medicinal Plants Research

Molecular docking studies on analogues of quercetin with d-alanine:d-alanine ligase of Helicobacter pylori

(2012) Salam Pradeep Singh et al.   MEDICINAL CHEMISTRY RESEARCH

Effects of Efflux Pump Inhibitors on Erythromycin, Ciprofloxacin, and Tetracycline Resistance in Campylobacter spp. Isolates

(2012) Marija Kurinčič et al.   Microbial Drug Resistance

Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers

(2012) Hayet Edziri et al.   MOLECULES

Plants as sources of new antimicrobials and resistance-modifying agents

(2012) Ana Cristina Abreu et al.   NATURAL PRODUCT REPORTS

Structural basis for TetM-mediated tetracycline resistance

(2012) A. Donhofer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibacterial and Antifungal Activities of New Acylated Derivatives of Epigallocatechin Gallate

(2012) Yoshimi Matsumoto et al.   Frontiers in Microbiology

Tea catechin epigallocatechin gallate inhibits Streptococcus mutans biofilm formation by suppressing gtf genes

(2011) Xin Xu et al.   ARCHIVES OF ORAL BIOLOGY

New Flavanones from the Leaves of Cryptocarya chinensis and Their Antituberculosis Activity

(2011) Tsung-Hsien Chou et al.   CHEMISTRY & BIODIVERSITY

A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome

(2011) Tushar Shakya et al.   CHEMISTRY & BIOLOGY

Antioxidant and prooxidant properties of flavonoids

(2011) D. Procházková et al.   FITOTERAPIA

Apple Flavonoid Phloretin Inhibits Escherichia coli O157:H7 Biofilm Formation and Ameliorates Colon Inflammation in Rats

(2011) Jin-Hyung Lee et al.   INFECTION AND IMMUNITY

Recent advances in understanding the antibacterial properties of flavonoids

(2011) T.P. Tim Cushnie et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Synergistic activity and mode of action of flavonoids isolated from smaller galangal and amoxicillin combinations against amoxicillin-resistant Escherichia coli

(2011) G. Eumkeb et al.   JOURNAL OF APPLIED MICROBIOLOGY

Synthesis and evaluation of antioxidant and antibacterial properties of morin complexes

(2011) Qadeer K. Panhwar et al.   JOURNAL OF COORDINATION CHEMISTRY

Flavonoids: Precipitation Kinetics and Interaction with Surfactant Micelles

(2011) David Löf et al.   JOURNAL OF FOOD SCIENCE

Antimicrobial Isopropenyl-dihydrofuranoisoflavones fromCrotalaria lachnophora

(2011) Maurice Ducret Awouafack et al.   JOURNAL OF NATURAL PRODUCTS

Activity of South African medicinal plants against Listeria monocytogenes biofilms, and isolation of active compounds from Acacia karroo

(2011) M.A. Nyila et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Pseudomonas aeruginosa: all roads lead to resistance

(2011) Elena B.M. Breidenstein et al.   TRENDS IN MICROBIOLOGY

Epidemiological Expansion, Structural Studies, and Clinical Challenges of New β-Lactamases from Gram-Negative Bacteria

(2010) Karen Bush et al.   Annual Review of Microbiology

Damage of the Bacterial Cell Envelope by Antimicrobial Peptides Gramicidin S and PGLa as Revealed by Transmission and Scanning Electron Microscopy

(2010) M. Hartmann et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Tea Catechin Epigallocatechin Gallate Suppresses Cariogenic Virulence Factors ofStreptococcus mutans

(2010) Xin Xu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Antibacterial Activity of Panduratin A against Enterococci Clinical Isolates

(2010) Yaya Rukayadi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Secondary Metabolites and Antimycobacterial Activities from the Roots of Ficus nervosa

(2010) Li-Wen Chen et al.   CHEMISTRY & BIODIVERSITY

Aminoglycoside modifying enzymes

(2010) Maria S. Ramirez et al.   DRUG RESISTANCE UPDATES

Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner

(2010) Nagababu Chinnam et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Antibacterial and Antifungal Properties of Acetonic Extract of Feijoa sellowiana Fruits and Its Effect on Helicobacter pylori Growth

(2010) Adriana Basile et al.   JOURNAL OF MEDICINAL FOOD

Exogenous Antioxidants—Double-Edged Swords in Cellular Redox State: Health Beneficial Effects at Physiologic Doses versus Deleterious Effects at High Doses

(2010) Jaouad Bouayed et al.   Oxidative Medicine and Cellular Longevity

Reversing β-lactam antibiotic resistance of Staphylococcus aureus with galangin from Alpinia officinarum Hance and synergism with ceftazidime

(2010) Griangsak Eumkeb et al.   PHYTOMEDICINE

Antimicrobial Activity of Flavonoids From Piper lanceaefolium and Other Colombian Medicinal Plants Against Antibiotic Susceptible and Resistant Strains of Neisseria gonorrhoeae

(2010) Patrick S. Ruddock et al.   SEXUALLY TRANSMITTED DISEASES

Plant phenotypic plasticity in a changing climate

(2010) A.B. Nicotra et al.   TRENDS IN PLANT SCIENCE

Respiratory infections in immunocompromised patients

(2009) Marcelo Corti et al.   CURRENT OPINION IN PULMONARY MEDICINE

Molecular Binding of Catechins to Biomembranes: Relationship to Biological Activity

(2009) Timothy W. Sirk et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Screening of Flavonoids as Candidate Antibiotics againstEnterococcus faecalis

(2009) Ki-Woong Jeong et al.   JOURNAL OF NATURAL PRODUCTS

Subinhibitory concentrations of licochalcone A decrease alpha-toxin production in both methicillin-sensitive and methicillin-resistantStaphylococcus aureusisolates

(2009) J. Qiu et al.   LETTERS IN APPLIED MICROBIOLOGY

Antimicrobial natural products: an update on future antibioticdrug candidates

(2009) Muhammad Saleem et al.   NATURAL PRODUCT REPORTS

Sepicanin A—A new geranyl flavanone from Artocarpus sepicanus with activity against methicillin-resistant Staphylococcus aureus (MRSA)

(2009) Mohamed M. Radwan et al.   Phytochemistry Letters

Inhibitory activity of Indian spice plant Cinnamomum zeylanicum extracts against Alternaria solani and Curvularia lunata, the pathogenic dematiaceous moulds

(2009) Ajay K Mishra et al.   Annals of Clinical Microbiology and Antimicrobials

Mechanisms of RND multidrug efflux pumps

(2008) Hiroshi Nikaido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The antibacterial efficacy of an aceraceous plant [Shantung maple (Acer truncatum Bunge)] may be related to inhibition of bacterial β-oxoacyl-acyl carrier protein reductase (FabG)

(2008) Feng Zhang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Safety of Green Tea Extracts

(2008) Dandapantula N Sarma et al.   DRUG SAFETY

Therapeutic Potential of Plants as Anti-Microbials for Drug Discovery

(2008) Ramar Perumal Samy et al.   Evidence-based Complementary and Alternative Medicine

d-Alanine:d-alanine ligase as a new target for the flavonoids quercetin and apigenin

(2008) Dalei Wu et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis

(2008) D. Lechner et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Investigation of the antibacterial activity of 3-O-octanoyl-(-)-epicatechin

(2008) T.P.T. Cushnie et al.   JOURNAL OF APPLIED MICROBIOLOGY

Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

(2008) Armelle Tsafack Mbaveng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

(2008) David J. Newman   JOURNAL OF MEDICINAL CHEMISTRY

AntibacterialC-Geranylflavonoids fromPaulownia tomentosaFruits

(2008) Karel Šmejkal et al.   JOURNAL OF NATURAL PRODUCTS

Complexation of Flavonoids with Iron:  Structure and Optical Signatures

(2008) Jun Ren et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

(2008) Irith Wiegand et al.   Nature Protocols

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

(2008) Jean-Marie Pagès et al.   NATURE REVIEWS MICROBIOLOGY

Modulation of isoniazid susceptibility by flavonoids in Mycobacterium

(2008) Doris Lechner et al.   Phytochemistry Letters

Three flavonoids targeting the β-hydroxyacyl-acyl carrier protein dehydratase fromHelicobacter pylori: Crystal structure characterization with enzymatic inhibition assay

(2008) Liang Zhang et al.   PROTEIN SCIENCE

Mechanism of inhibition of wt-dihydrofolate reductase fromE. coliby tea epigallocatechin-gallate

(2008) Michele Spina et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Antimicrobial, antioxidant, and antiviral activities of Retama raetam (Forssk.) Webb flowers growing in Tunisia

(2008) Edziri Hayet et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Small multidrug resistance proteins: A multidrug transporter family that continues to grow

(2007) Denice C. Bay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES