Basophil-derived IL-4 plays versatile roles in immunity

Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain

(2016) Seiji Kamijo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection

(2015) Camille Blériot et al.   IMMUNITY

IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function

(2015) Laurence E. Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Basophils have emerged as a key player in immunity

(2014) Hajime Karasuyama et al.   CURRENT OPINION IN IMMUNOLOGY

I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis

(2014) Jakob von Moltke et al.   CURRENT OPINION IN IMMUNOLOGY

Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation

(2014) Yasutaka Motomura et al.   IMMUNITY

Basophils as a primary inducer of the T helper type 2 immunity in ovalbumin-induced allergic airway inflammation

(2014) Wenwei Zhong et al.   IMMUNOLOGY

Basophils regulate the recruitment of eosinophils in a murine model of irritant contact dermatitis

(2014) Chisa Nakashima et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Therapeutic Effect of IVIG on Inflammatory Arthritis in Mice Is Dependent on the Fc Portion and Independent of Sialylation or Basophils

(2014) I. K. Campbell et al.   JOURNAL OF IMMUNOLOGY

Basophils Promote Innate Lymphoid Cell Responses in Inflamed Skin

(2014) Brian S. Kim et al.   JOURNAL OF IMMUNOLOGY

Signaling pathways activated by a protease allergen in basophils

(2014) Rachel K. Rosenstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

(2013) Steven J. Van Dyken et al.   Annual Review of Immunology

Development and function of group 2 innate lymphoid cells

(2013) Jennifer A Walker et al.   CURRENT OPINION IN IMMUNOLOGY

Activation of human basophils by combined toll-like receptor- and FcεRI-triggering can promote Th2 skewing of naive T helper cells

(2013) Jolien Suurmond et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4

(2013) Mayumi Egawa et al.   IMMUNITY

Basophils and allergic inflammation

(2013) Mark C. Siracusa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The skin is an important bulwark of acquired immunity against intestinal helminths

(2013) Kazushige Obata-Ninomiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Basophils control T-cell responses and limit disease activity in experimental murine colitis

(2013) M Rodriguez Gomez et al.   Mucosal Immunology

Basophils are required for the induction of Th2 immunity to haptens and peptide antigens

(2013) Atsushi Otsuka et al.   Nature Communications

Basophils are recruited to inflamed lungs and exacerbate memory Th2 responses in mice and humans

(2012) K. Wakahara et al.   ALLERGY

Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness

(2012) M. Sawaguchi et al.   JOURNAL OF IMMUNOLOGY

Nonredundant Roles of Basophils in Immunity

(2011) Hajime Karasuyama et al.   Annual Review of Immunology

Host Basophils Are Dispensable for Induction of Donor T Helper 2 Cell Differentiation and Severity of Experimental Graft-versus-Host Disease

(2011) Isao Tawara et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Basophils: emerging roles in the pathogenesis of allergic disease

(2011) John T. Schroeder   IMMUNOLOGICAL REVIEWS

Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2

(2011) Mankit Law et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation

(2011) Mark C. Siracusa et al.   NATURE

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

Genetic analysis of basophil function in vivo

(2011) Brandon M Sullivan et al.   NATURE IMMUNOLOGY

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Mast cell signaling: The role of protein tyrosine kinase Syk, its activation and screening methods for new pathway participants

(2010) Reuben P. Siraganian et al.   FEBS LETTERS

Basophils Orchestrate Chronic Allergic Dermatitis and Protective Immunity against Helminths

(2010) Caspar Ohnmacht et al.   IMMUNITY

Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks

(2010) Takeshi Wada et al.   JOURNAL OF CLINICAL INVESTIGATION

CD11c depletion severely disrupts Th2 induction and development in vivo

(2010) Alexander T. Phythian-Adams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

(2010) Hamida Hammad et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

The T helper type 2 response to cysteine proteases requires dendritic cell–basophil cooperation via ROS-mediated signaling

(2010) Hua Tang et al.   NATURE IMMUNOLOGY

Basophils and the T helper 2 environment can promote the development of lupus nephritis

(2010) Nicolas Charles et al.   NATURE MEDICINE

IL-33 and IL-33 Receptors in Host Defense and Diseases

(2010) Keisuke Oboki et al.   ALLERGOLOGY INTERNATIONAL

Lyn Kinase Controls Basophil GATA-3 Transcription Factor Expression and Induction of Th2 Cell Differentiation

(2009) Nicolas Charles et al.   IMMUNITY

Basophils Can Directly Present or Cross-Present Antigen to CD8 Lymphocytes and Alter CD8 T Cell Differentiation into IL-10-Producing Phenotypes

(2009) S. Kim et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Basophils Are Transiently Recruited into the Draining Lymph Nodes during Helminth Infection via IL-3, but Infection-Induced Th2 Immunity Can Develop without Basophil Lymph Node Recruitment or IL-3

(2009) S. Kim et al.   JOURNAL OF IMMUNOLOGY

IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38α-dependent pathway

(2009) Kelly M. Kroeger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The phenotype of murine wound macrophages

(2009) Jean M. Daley et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Basophils contribute to TH2-IgE responses in vivo via IL-4 production and presentation of peptide–MHC class II complexes to CD4+ T cells

(2009) Tomohiro Yoshimoto et al.   NATURE IMMUNOLOGY

MHC class II–dependent basophil–CD4+ T cell interactions promote TH2 cytokine–dependent immunity

(2009) Jacqueline G Perrigoue et al.   NATURE IMMUNOLOGY

Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils

(2009) Kang Chen et al.   NATURE IMMUNOLOGY

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

(2009) Caroline L Sokol et al.   NATURE IMMUNOLOGY

Fc receptor γ-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils

(2008) Shigeaki Hida et al.   NATURE IMMUNOLOGY

Basophils enhance immunological memory responses

(2008) Andrea Denzel et al.   NATURE IMMUNOLOGY