Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death

Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells

(2018) Maceler Aldrovandi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease

(2017) Stefan Uderhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-chain acyl-CoA synthetase isoforms differ in preferences for eicosanoid species and long-chain fatty acids

(2017) Eric L. Klett et al.   JOURNAL OF LIPID RESEARCH

Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis

(2017) Sarah N. Lauder et al.   Science Signaling

Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation

(2017) Yury I. Miller et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis

(2017) Sarah N. Lauder et al.   Science Signaling

DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression

(2017) Maceler Aldrovandi et al.   Redox Biology

Mapping the Human Platelet Lipidome Reveals Cytosolic Phospholipase A2 as a Regulator of Mitochondrial Bioenergetics during Activation

(2016) David A. Slatter et al.   Cell Metabolism

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

(2016) Ivan Zanoni et al.   SCIENCE

Secreted lipoxygenase from Pseudomonas aeruginosa exhibits biomembrane oxygenase activity and induces hemolysis in human red blood cells

(2015) Swathi Banthiya et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2

(2015) P. Bretscher et al.   EMBO Molecular Medicine

12/15-lipoxygenase–mediated enzymatic lipid oxidation regulates DC maturation and function

(2015) Tobias Rothe et al.   JOURNAL OF CLINICAL INVESTIGATION

A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation

(2015) Kathy Stein et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Toll-like receptor 4 senses oxidative stress mediated by the oxidation of phospholipids in extracellular vesicles

(2015) Mateja Manček-Keber et al.   Science Signaling

Toll-like receptor 4 senses oxidative stress mediated by the oxidation of phospholipids in extracellular vesicles

(2015) Mateja Manček-Keber et al.   Science Signaling

Eosinophils control the resolution of inflammation and draining lymph node hypertrophy through the proresolving mediators and CXCL13 pathway in mice

(2014) Yukako Tani et al.   FASEB JOURNAL

12/15-Lipoxygenase Regulates the Inflammatory Response to Bacterial Products In Vivo

(2014) V. Dioszeghy et al.   JOURNAL OF IMMUNOLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

A mitochondrial pathway for biosynthesis of lipid mediators

(2014) Yulia Y. Tyurina et al.   Nature Chemistry

Human platelets generate phospholipid-esterified prostaglandins via cyclooxygenase-1 that are inhibited by low dose aspirin supplementation

(2013) Maceler Aldrovandi et al.   JOURNAL OF LIPID RESEARCH

Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation

(2013) S. R. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis

(2012) Gerhard Krönke et al.   ANNALS OF THE RHEUMATIC DISEASES

Bioactive oxidatively truncated phospholipids in inflammation and apoptosis: Formation, targets, and inactivation

(2012) Thomas M. McIntyre   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Chemistry of phospholipid oxidation

(2012) Ana Reis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

New families of bioactive oxidized phospholipids generated by immune cells: identification and signaling actions

(2012) V. B. O'Donnell et al.   BLOOD

Structural Identification and Cardiovascular Activities of Oxidized Phospholipids

(2012) Robert G. Salomon   CIRCULATION RESEARCH

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

(2012) Stefan Uderhardt et al.   IMMUNITY

Novel Keto-phospholipids Are Generated by Monocytes and Macrophages, Detected in Cystic Fibrosis, and Activate Peroxisome Proliferator-activated Receptor-γ

(2012) Victoria J. Hammond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of unsaturated lipids by ozone-induced dissociation

(2011) Simon H.J. Brown et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Molecular Determinants of Phospholipid Synergy in Blood Clotting

(2011) Narjes Tavoosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombin-activated human platelets acutely generate oxidized docosahexaenoic-acid-containing phospholipids via 12-lipoxygenase

(2010) Lloyd T. Morgan et al.   BIOCHEMICAL JOURNAL

Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection

(2010) S. R. Clark et al.   BLOOD

Identification of a Novel Macrophage Phenotype That Develops in Response to Atherogenic Phospholipids via Nrf2

(2010) Alexandra Kadl et al.   CIRCULATION RESEARCH

Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice

(2010) Tomohiro Yamada et al.   FASEB JOURNAL

Phospholipid-esterified Eicosanoids Are Generated in Agonist-activated Human Platelets and Enhance Tissue Factor-dependent Thrombin Generation

(2010) Christopher P. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative assays for esterified oxylipins generated by immune cells

(2010) Alwena H Morgan et al.   Nature Protocols

Interleukin-13–induced MUC5AC Is Regulated by 15-Lipoxygenase 1 Pathway in Human Bronchial Epithelial Cells

(2009) Jinming Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Generation and Biological Activities of Oxidized Phospholipids

(2009) Valery N. Bochkov et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidized Phospholipids Induce Type VIII Collagen Expression and Vascular Smooth Muscle Cell Migration

(2009) Olga A. Cherepanova et al.   CIRCULATION RESEARCH

Phosphatidylethanolamine-esterified Eicosanoids in the Mouse

(2009) Alwena H. Morgan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

12/15-Lipoxygenase Counteracts Inflammation and Tissue Damage in Arthritis

(2009) G. Kronke et al.   JOURNAL OF IMMUNOLOGY

Multi-Hit Inhibition of Circulating and Cell-Associated Components of the Toll-Like Receptor 4 Pathway by Oxidized Phospholipids

(2008) Elena von Schlieffen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Oxidized Phospholipids as Endogenous Pattern Recognition Ligands in Innate Immunity

(2008) Stanley L. Hazen   JOURNAL OF BIOLOGICAL CHEMISTRY

Arachidonic acid cytochrome P450 epoxygenase pathway

(2008) Arthur A. Spector   JOURNAL OF LIPID RESEARCH