The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones

An Aza resveratrol-chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress

(2018) Shengban You et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220

(2018) Ji Ae Lee et al.   NEUROCHEMISTRY INTERNATIONAL

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

(2018) Antonio Cuadrado et al.   PHARMACOLOGICAL REVIEWS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice

(2017) Zheng Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016)

(2017) Haopeng Sun et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Chalcone-based carbamates for Alzheimer’s disease treatment

(2017) Angela Rampa et al.   Future Medicinal Chemistry

Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway

(2017) Jun Zeng et al.   Journal of Neuroinflammation

Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice

(2017) Renata M. Martinez et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Chalcone Derivatives: Promising Starting Points for Drug Design

(2017) Marcelo Gomes et al.   MOLECULES

Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative

(2017) Jun Wei et al.   Translational Research

Activation of Nrf2-driven antioxidant enzymes by cardamonin confers neuroprotection of PC12 cells against oxidative damage

(2017) Shoujiao Peng et al.   Food & Function

Inhibition of interleukin-3- and interferon- α-induced JAK/STAT signaling by the synthetic α-X-2′,3,4,4′-tetramethoxychalcones α-Br-TMC and α-CF3-TMC

(2016) Belinda Jobst et al.   BIOLOGICAL CHEMISTRY

Redox-based therapeutics in neurodegenerative disease

(2016) G J McBean et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2-regulated antioxidant enzymes in intestinal Caco-2 cells

(2016) Silke De Spirt et al.   FREE RADICAL BIOLOGY AND MEDICINE

The anti-inflammatory effects of E -α-( p -methoxyphenyl)-2′,3,4,4′-tetramethoxychalcone are mediated via HO-1 induction

(2016) Kai B. Kaufmann et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Safflower yellow B suppresses HepG2 cell injury induced by oxidative stress through the AKT/Nrf2 pathway

(2016) ZHONGYING MA et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway

(2016) TIANXIN HU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats

(2016) MINCHUN CHEN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

(2016) Meng-Chen Lu et al.   MEDICINAL RESEARCH REVIEWS

A click chemistry approach identifies target proteins of xanthohumol

(2016) Lidia Brodziak-Jarosz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Flavokawains A and B from kava (Piper methysticum) activate heat shock and antioxidant responses and protect against hydrogen peroxide-induced cell death in HepG2 hepatocytes

(2016) Keanu D. Pinner et al.   PHARMACEUTICAL BIOLOGY

Topical formulation containing hesperidin methyl chalcone inhibits skin oxidative stress and inflammation induced by ultraviolet B irradiation

(2016) Renata M. Martinez et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function

(2015) Thomas E. Sussan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways

(2015) Joanna D. Wardyn et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Blockage of ROS and NF-κB-mediated inflammation by a new chalcone L6H9 protects cardiomyocytes from hyperglycemia-induced injuries

(2015) Peng Zhong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Heterocyclic chalcone activators of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) with improved in vivo efficacy

(2015) Nicole Lounsbury et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of paralleled Aza resveratrol–chalcone compounds as potential anti-inflammatory agents for the treatment of acute lung injury

(2015) Wenbo Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation

(2015) Rui Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Xanthohumol, a Polyphenol Chalcone Present in Hops, Activating Nrf2 Enzymes To Confer Protection against Oxidative Damage in PC12 Cells

(2015) Juan Yao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Enhancing the anti-inflammatory activity of chalcones by tuning the Michael acceptor site

(2015) Hannelore Rücker et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The chalcone compound isosalipurposide (ISPP) exerts a cytoprotective effect against oxidative injury via Nrf2 activation

(2015) Jae Yun Han et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

(2015) Dhulfiqar Ali Abed et al.   Acta Pharmaceutica Sinica B

The Cytoprotective Effects of E-α-(4-Methoxyphenyl)-2’,3,4,4'-Tetramethoxychalcone (E-α-p-OMe-C6H4-TMC)—A Novel and Non-Cytotoxic HO-1 Inducer

(2015) Kai B. Kaufmann et al.   PLoS One

Recent developments in biological activities of chalcones: A mini review

(2014) Parvesh Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Chalcones with Potent Antioxidant Ability on H2O2-Induced Apoptosis in PC12 Cells

(2014) Jian-Zhang Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

4,2′,5′-Trihydroxy-4′-methoxychalcone from Dalbergia odorifera exhibits anti-inflammatory properties by inducing heme oxygenase-1 in murine macrophages

(2013) Dong-Sung Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Electrophilic and Reactive Oxygen Species Detoxification Potentials of Chalcone Dimers is Mediated by Redox Transcription Factor Nrf-2

(2013) Taofeek O. Ajiboye et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Chemical reactivity and biological activity of chalcones and other α,β-unsaturated carbonyl compounds

(2013) Daniela Maydt et al.   XENOBIOTICA

Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease

(2012) Sa Suk Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

2′,5′-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways

(2011) Remy Kachadourian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Upregulation of heme oxygenase-1 expression by hydroxysafflor yellow A conferring protection from anoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes

(2011) Shan-Xin Liu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells

(2011) Vineet Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemistry of the Cysteine Sensors in Kelch-Like ECH-Associated Protein 1

(2010) Ryan Holland et al.   ANTIOXIDANTS & REDOX SIGNALING

2′-Methoxy-4′6′-Bis(Methoxymethoxy)Chalcone Inhibits Nitric Oxide Production in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

(2010) Xing Yu Jin et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Sofalcone, a gastric mucosa protective agent, increases vascular endothelial growth factor via the Nrf2-heme-oxygenase-1 dependent pathway in gastric epithelial cells

(2010) Akiko Shibuya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-inflammatory activity of xanthohumol involves heme oxygenase-1 induction via NRF2-ARE signaling in microglial BV2 cells

(2010) Ik-Soo Lee et al.   NEUROCHEMISTRY INTERNATIONAL

The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2

(2010) Jonathan Maher et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

YL-I-108, a synthetic chalcone derivative, inhibits lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 murine macrophages: Involvement of heme oxygenase-1 induction and blockade of activator protein-1

(2009) Pil-Hoon Park et al.   ARCHIVES OF PHARMACAL RESEARCH

KB-34, a newly synthesized chalcone derivative, inhibits lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages via heme oxygenase-1 induction and blockade of activator protein-1

(2009) Pil-Hoon Park et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Licochalcone A Potently Inhibits Tumor Necrosis Factor  -Induced Nuclear Factor- B Activation through the Direct Inhibition of I B Kinase Complex Activation

(2009) M. Funakoshi-Tago et al.   MOLECULAR PHARMACOLOGY

Inhibition of IκB Kinase-β and Anticancer Activities of Novel Chalcone Adamantyl Arotinoids

(2008) Paula Lorenzo et al.   JOURNAL OF MEDICINAL CHEMISTRY