Sex, gut microbiome, and cardiovascular disease risk

The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage

(2019) Hendrik Bartolomaeus et al.   CIRCULATION

Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in cardiovascular disease

(2018) Judith N. Lezutekong et al.   CLINICAL SCIENCE

Gut microbial diversity is associated with lower arterial stiffness in women

(2018) Cristina Menni et al.   EUROPEAN HEART JOURNAL

Sex-specific differences in hypertension and associated cardiovascular disease

(2018) Katrina M. Mirabito Colafella et al.   Nature Reviews Nephrology

Sex differences in lipid and lipoprotein metabolism

(2018) Brian T. Palmisano et al.   Molecular Metabolism

Sex differences in lipid metabolism are affected by presence of the gut microbiota

(2018) Annemarie Baars et al.   Scientific Reports

Childhood Obesity and Firmicutes/Bacteroidetes Ratio in the Gut Microbiota: A Systematic Review

(2018) Cláudia Maria dos Santos Pereira Indiani et al.   Childhood Obesity

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

(2018) Manuel Janeiro et al.   Nutrients

Circulating trimethylamine N-oxide and the risk of cardiovascular diseases: a systematic review and meta-analysis of 11 prospective cohort studies

(2017) Jiaqian Qi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease

(2017) James A.P. Tomlinson et al.   KIDNEY INTERNATIONAL

Salt-responsive gut commensal modulates TH17 axis and disease

(2017) Nicola Wilck et al.   NATURE

Beyond gut feelings: how the gut microbiota regulates blood pressure

(2017) Francine Z. Marques et al.   Nature Reviews Cardiology

Association between Yogurt Consumption and Intestinal Microbiota in Healthy Young Adults Differs by Host Gender

(2017) Yoshio Suzuki et al.   Frontiers in Microbiology

Gut microbiota dysbiosis contributes to the development of hypertension

(2017) Jing Li et al.   Microbiome

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

(2017) Lucy Brooks et al.   Molecular Metabolism

Real-time imaging of intestinal bacterial β-glucuronidase activity by hydrolysis of a fluorescent probe

(2017) Michael Chen et al.   Scientific Reports

Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation

(2017) Lili Sheng et al.   Scientific Reports

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial

(2017) Emanuel E. Canfora et al.   Scientific Reports

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Renal Dysfunction, Rather Than Nonrenal Vascular Dysfunction, Mediates Salt-Induced HypertensionResponse to Hall

(2016) John E. Hall   CIRCULATION

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive MiceClinical Perspective

(2016) Francine Z. Marques et al.   CIRCULATION

Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men

(2016) C. M. van der Beek et al.   CLINICAL SCIENCE

Sex Differences in Hypertension

(2016) Ellen E. Gillis et al.   HYPERTENSION

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

(2016) M Sahuri-Arisoylu et al.   INTERNATIONAL JOURNAL OF OBESITY

Arterial hypertension in the female world

(2016) Christian Cadeddu et al.   Journal of Cardiovascular Medicine

The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction

(2016) Giuseppe Lo Sasso et al.   Journal of Translational Medicine

Cause-specific mortality for 240 causes in China during 1990–2013: a systematic subnational analysis for the Global Burden of Disease Study 2013

(2016) Maigeng Zhou et al.   LANCET

Vinegar as a functional ingredient to improve postprandial glycemic control-human intervention findings and molecular mechanisms

(2016) Joseph Lim et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

Diet–microbiota interactions as moderators of human metabolism

(2016) Justin L. Sonnenburg et al.   NATURE

Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41

(2016) Niranjana Natarajan et al.   PHYSIOLOGICAL GENOMICS

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?

(2016) Zhiwei Ang et al.   Frontiers in Immunology

Intestinal Microbiota Is Influenced by Gender and Body Mass Index

(2016) Carmen Haro et al.   PLoS One

Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen

(2016) Hong-Jai Park et al.   Scientific Reports

Short Chain Fatty Acids Prevent High-fat-diet-induced Obesity in Mice by Regulating G Protein-coupled Receptors and Gut Microbiota

(2016) Yuanyuan Lu et al.   Scientific Reports

Sex differences in colonization of gut microbiota from a man with short-term vegetarian and inulin-supplemented diet in germ-free mice

(2016) Jing-jing Wang et al.   Scientific Reports

Sex Differences in Platelet Toll-Like Receptors and Their Association With Cardiovascular Risk FactorsSignificance

(2015) Milka Koupenova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Comparison of the gut microbiota composition between obese and non-obese individuals in a Japanese population, as analyzed by terminal restriction fragment length polymorphism and next-generation sequencing

(2015) Chika Kasai et al.   BMC GASTROENTEROLOGY

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella

(2015) Petia Kovatcheva-Datchary et al.   Cell Metabolism

Antihypertensive activity of blueberries fermented by Lactobacillus plantarum DSM 15313 and effects on the gut microbiota in healthy rats

(2015) Irini Lazou Ahrén et al.   CLINICAL NUTRITION

Gut microbiota in hypertension

(2015) Pedro A. Jose et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

GPR43 Potentiates β-Cell Function in Obesity

(2015) Joanne C. McNelis et al.   DIABETES

Gut Dysbiosis Is Linked to HypertensionNovelty and Significance

(2015) Tao Yang et al.   HYPERTENSION

Immune Mechanisms in Arterial Hypertension

(2015) U. Wenzel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Gender-specific pathway differences in the human serum metabolome

(2015) Jan Krumsiek et al.   Metabolomics

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion

(2015) Medha Priyadarshini et al.   MOLECULAR ENDOCRINOLOGY

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

(2015) Benoit Chassaing et al.   NATURE

Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

(2015) Cong Tang et al.   NATURE MEDICINE

Gut microbiota-derived lipopolysaccharide uptake and trafficking to adipose tissue: implications for inflammation and obesity

(2015) L. -G. Hersoug et al.   Obesity Reviews

Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function

(2015) Anisha A. Gupte et al.   Journal of Diabetes Research

Dietary quality among men and women in 187 countries in 1990 and 2010: a systematic assessment

(2015) Fumiaki Imamura et al.   Lancet Global Health

Sex, Body Mass Index, and Dietary Fiber Intake Influence the Human Gut Microbiome

(2015) Christine Dominianni et al.   PLoS One

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Compositional and Functional Features of the Gastrointestinal Microbiome and Their Effects on Human Health

(2014) Emily B. Hollister et al.   GASTROENTEROLOGY

Effect of Probiotics on Blood Pressure

(2014) Saman Khalesi et al.   HYPERTENSION

Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity

(2014) Amandine Everard et al.   ISME Journal

Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

(2014) Jill C. Gregory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Pressure natriuresis and the renal control of arterial blood pressure

(2014) Jessica R. Ivy et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Metabolite Profiles of the Obese Population Are Gender-Dependent

(2014) Guoxiang Xie et al.   JOURNAL OF PROTEOME RESEARCH

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

(2014) Bogna Grygiel-Górniak   Nutrition Journal

Anti-Inflammatory Effects of Progesterone in Lipopolysaccharide-Stimulated BV-2 Microglia

(2014) Beilei Lei et al.   PLoS One

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

Gut microbiome of the Hadza hunter-gatherers

(2014) Stephanie L. Schnorr et al.   Nature Communications

Regulation of Energy Homeostasis by GPR41

(2014) Daisuke Inoue et al.   Frontiers in Endocrinology

The Effect of Sex Hormones on Peroxisome Proliferator-Activated Receptor Gamma Expression and Activity in Mature Adipocytes

(2013) Hiromi Sato et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

(2013) Brian J. Bennett et al.   Cell Metabolism

Immune mechanisms in hypertension and vascular injury

(2013) Ernesto L. Schiffrin   CLINICAL SCIENCE

Gender Bias in Autoimmunity Is Influenced by Microbiota

(2013) Leonid Yurkovetskiy et al.   IMMUNITY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

The gut as a sensory organ

(2013) John B. Furness et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypertension: What's Sex Got to do With It?

(2013) Margaret A. Zimmerman et al.   PHYSIOLOGY

Acetic Acid Activates the AMP-Activated Protein Kinase Signaling Pathway to Regulate Lipid Metabolism in Bovine Hepatocytes

(2013) Xinwei Li et al.   PLoS One

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Commensal Clostridia: leading players in the maintenance of gut homeostasis

(2013) Loris R Lopetuso et al.   Gut Pathogens

Body Fat Distribution and Insulin Resistance

(2013) Pavankumar Patel et al.   Nutrients

The Role of Gut Microbiota on Insulin Resistance

(2013) Andrea Caricilli et al.   Nutrients

Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1

(2013) Limin Han et al.   Protein & Cell

Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content

(2012) Mohamed Bellahcene et al.   BRITISH JOURNAL OF NUTRITION

Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy

(2012) Omry Koren et al.   CELL

Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach

(2012) A. Floegel et al.   DIABETES

Phylogenetic distribution of genes encoding β-glucuronidase activity in human colonic bacteria and the impact of diet on faecal glycosidase activities

(2012) Freda M. McIntosh et al.   ENVIRONMENTAL MICROBIOLOGY

Intravenous acetate elicits a greater free fatty acid rebound in normal than hyperinsulinaemic humans

(2012) J Fernandes et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Sex differences in TLR2 and TLR4 expression and their effect on coxsackievirus-induced autoimmune myocarditis

(2012) Brian J. Roberts et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

High-Fat Diet Induces Periodontitis in Mice through Lipopolysaccharides (LPS) Receptor Signaling: Protective Action of Estrogens

(2012) Vincent Blasco-Baque et al.   PLoS One

Sex/Gender Differences in Cardiovascular Disease Prevention

(2011) Lori Mosca et al.   CIRCULATION

Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii

(2011) M Million et al.   INTERNATIONAL JOURNAL OF OBESITY

Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans

(2011) Eugene P. Rhee et al.   JOURNAL OF CLINICAL INVESTIGATION

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

(2011) B. D. Muegge et al.   SCIENCE

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

(2011) G. D. Wu et al.   SCIENCE

Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice

(2011) Andréa M. Caricilli et al.   PLOS BIOLOGY

Altered Gut Microbiota and Endocannabinoid System Tone in Obese and Diabetic Leptin-Resistant Mice: Impact on Apelin Regulation in Adipose Tissue

(2011) Lucie Geurts et al.   Frontiers in Microbiology

Predicting Survival in Pulmonary Arterial Hypertension

(2010) Raymond L. Benza et al.   CIRCULATION

Estrogen, hormonal replacement therapy and cardiovascular disease

(2010) Xiao-Ping Yang et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease

(2010) Zhao-Xia Yang et al.   Hepatology International

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

(2010) Alan W Walker et al.   ISME Journal

A metagenomic  -glucuronidase uncovers a core adaptive function of the human intestinal microbiome

(2010) K. Gloux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

(2009) D Mariat et al.   BMC MICROBIOLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Estrogens Protect against High-Fat Diet-Induced Insulin Resistance and Glucose Intolerance in Mice

(2009) Elodie Riant et al.   ENDOCRINOLOGY

Estrogens Augment Cell Surface TLR4 Expression on Murine Macrophages and Regulate Sepsis Susceptibilityin Vivo

(2009) Jennifer A. Rettew et al.   ENDOCRINOLOGY

Sexual differences in the control of energy homeostasis

(2009) Haifei Shi et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Gender differences in insulin resistance, body composition, and energy balance

(2009) Eliza B. Geer et al.   Gender Medicine

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Central effects of estradiol in the regulation of food intake, body weight, and adiposity

(2009) L.M. Brown et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Sex Differences in Regional Body Fat Distribution From Pre- to Postpuberty

(2009) Rachael W. Taylor et al.   Obesity

Gender Differences in Lipid Metabolism and the Effect of Obesity

(2009) Faidon Magkos et al.   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

Changes in Insulin Resistance and Cardiovascular Risk During Adolescence

(2008) Antoinette Moran et al.   CIRCULATION

Gender difference in blood pressure responses to dietary sodium intervention in the GenSalt study

(2008) Jiang He et al.   JOURNAL OF HYPERTENSION

The association of endogenous sex hormones with lipoprotein subfraction profile in the Multi-Ethnic Study of Atherosclerosis

(2008) Dhananjay Vaidya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Symbiotic gut microbes modulate human metabolic phenotypes

(2008) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of Mammals and Their Gut Microbes

(2008) R. E. Ley et al.   SCIENCE

Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity

(2007) Jennifer A. Rettew et al.   BIOLOGY OF REPRODUCTION