Stress-Activated Protein Kinases in Human Fungal Pathogens

The AGC Kinase YpkA Regulates Sphingolipids Biosynthesis and Physically Interacts With SakA MAP Kinase in Aspergillus fumigatus

(2019) João Henrique Tadini Marilhano Fabri et al.   Frontiers in Microbiology

The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans

(2019) Adnane Sellam et al.   PLoS Genetics

Redox Regulation, Rather than Stress-Induced Phosphorylation, of a Hog1 Mitogen-Activated Protein Kinase Modulates Its Nitrosative-Stress-Specific Outputs

(2018) Carmen Herrero-de-Dios et al.   mBio

Intracellular mechanism by which arsenite activates the yeast stress MAPK Hog1

(2018) Jongmin Lee et al.   MOLECULAR BIOLOGY OF THE CELL

High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis

(2018) Teresa R. O’Meara et al.   mBio

Protein Kinase A and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in Aspergillus fumigatus

(2018) Leandro José de Assis et al.   mBio

Sho1 and Msb2 Play Complementary but Distinct Roles in Stress Responses, Sexual Differentiation, and Pathogenicity of Cryptococcus neoformans

(2018) Yee-Seul So et al.   Frontiers in Microbiology

Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis

(2017) Radha Rajasingham et al.   LANCET INFECTIOUS DISEASES

The yeasts phosphorelay systems: a comparative view

(2017) Griselda Salas-Delgado et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

The water channel protein aquaporin 1 regulates cellular metabolism and competitive fitness in a global fungal pathogen C ryptococcus neoformans

(2017) Gena Lee Meyers et al.   Environmental Microbiology Reports

Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen

(2017) Alison M. Day et al.   Scientific Reports

Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation

(2017) Alison M. Day et al.   PLoS Pathogens

The Hog1 MAP Kinase Promotes the Recovery from Cell Cycle Arrest Induced by Hydrogen Peroxide in Candida albicans

(2017) Inês Correia et al.   Frontiers in Microbiology

Genome-wide transcriptome analysis of Aspergillus fumigatus exposed to osmotic stress reveals regulators of osmotic and cell wall stresses that are SakAHOG1 and MpkC dependent

(2016) Lilian Pereira Silva et al.   CELLULAR MICROBIOLOGY

Opposing PKA and Hog1 signals control the post-transcriptional response to glucose availability inCryptococcus neoformans

(2016) Dithi Banerjee et al.   MOLECULAR MICROBIOLOGY

Mitogen activated protein kinases SakAHOG1and MpkC collaborate forAspergillus fumigatusvirulence

(2016) Ariane Cristina Mendes de Oliveira Bruder Nascimento et al.   MOLECULAR MICROBIOLOGY

Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis

(2016) Elizabeth J. Polvi et al.   PLoS Genetics

Neutrophil Attack Triggers Extracellular Trap-Dependent Candida Cell Wall Remodeling and Altered Immune Recognition

(2016) Alex Hopke et al.   PLoS Pathogens

Fungi use the SakA (HogA) pathway for phytochrome-dependent light signalling

(2016) Zhenzhong Yu et al.   Nature Microbiology

Systematic gene deletion and functional characterization of histidine kinase phosphorelay receptors (HKRs) in the human pathogenic fungus Aspergillus fumigatus

(2015) F. Chapeland-Leclerc et al.   FUNGAL GENETICS AND BIOLOGY

Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex

(2015) Ferry Hagen et al.   FUNGAL GENETICS AND BIOLOGY

High osmolarity glycerol response PtcB phosphatase is important forAspergillus fumigatusvirulence

(2015) Lizziane K. Winkelströter et al.   MOLECULAR MICROBIOLOGY

Osmosensing and scaffolding functions of the oligomeric four-transmembrane domain osmosensor Sho1

(2015) Kazuo Tatebayashi et al.   Nature Communications

A Case for Two-Component Signaling Systems As Antifungal Drug Targets

(2015) Erika Shor et al.   PLoS Pathogens

Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus

(2015) Robert Altwasser et al.   PLoS One

Two-Component Histidine Phosphotransfer Protein Ypd1 Is Not Essential for Viability in Candida albicans

(2014) John Mavrianos et al.   EUKARYOTIC CELL

Distinct and Redundant Roles of Protein Tyrosine Phosphatases Ptp1 and Ptp2 in Governing the Differentiation and Pathogenicity of Cryptococcus neoformans

(2014) Kyung-Tae Lee et al.   EUKARYOTIC CELL

A Novel Function for Hog1 Stress-Activated Protein Kinase in Controlling White-Opaque Switching and Mating in Candida albicans

(2014) Shen-Huan Liang et al.   EUKARYOTIC CELL

The role of AtfA and HOG MAPK pathway in stress tolerance in conidia of Aspergillus fumigatus

(2014) Daisuke Hagiwara et al.   FUNGAL GENETICS AND BIOLOGY

ChIP-seq reveals a role for CrzA in theAspergillus fumigatushigh-osmolarity glycerol response (HOG) signalling pathway

(2014) Patrícia A. de Castro et al.   MOLECULAR MICROBIOLOGY

The HOG Pathway Is Critical for the Colonization of the Mouse Gastrointestinal Tract by Candida albicans

(2014) Daniel Prieto et al.   PLoS One

Yeast Osmosensors Hkr1 and Msb2 Activate the Hog1 MAPK Cascade by Different Mechanisms

(2014) K. Tanaka et al.   Science Signaling

Hog1: 20 years of discovery and impact

(2014) J. L. Brewster et al.   Science Signaling

A Ferroxidase, Cfo1, Regulates Diverse Environmental Stress Responses of Cryptococcus neoformans through the HOG Pathway

(2014) Kyung-Tae Lee et al.   MYCOBIOLOGY

Mitochondria InfluenceCDR1Efflux Pump Activity, Hog1-Mediated Oxidative Stress Pathway, Iron Homeostasis, and Ergosterol Levels in Candida albicans

(2013) Edwina Thomas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification and Mechanism of Action of the Plant Defensin NaD1 as a New Member of the Antifungal Drug Arsenal against Candida albicans

(2013) Brigitte M. E. Hayes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Involvement of the mitogen activated protein kinase Hog1p in the response of Candida albicans to iron availability

(2013) Hani EJ Kaba et al.   BMC MICROBIOLOGY

MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators

(2013) J. Lee et al.   GENES & DEVELOPMENT

Genome-wide transcriptional profiling and enrichment mapping reveal divergent and conserved roles of Sko1 in the Candida albicans osmotic stress response

(2013) Dawn H. Marotta et al.   GENOMICS

Sulphiredoxin plays peroxiredoxin-dependent and -independent roles via the HOG signalling pathway inCryptococcus neoformansand contributes to fungal virulence

(2013) Rajendra Upadhya et al.   MOLECULAR MICROBIOLOGY

NikA/TcsC Histidine Kinase Is Involved in Conidiation, Hyphal Morphology, and Responses to Osmotic Stress and Antifungal Chemicals in Aspergillus fumigatus

(2013) Daisuke Hagiwara et al.   PLoS One

The Fungal Pathogen Aspergillus fumigatus Regulates Growth, Metabolism, and Stress Resistance in Response to Light

(2013) K. K. Fuller et al.   mBio

A novel dehydrin-like protein from Aspergillus fumigatus regulates freezing tolerance

(2012) Joanne Wong Sak Hoi et al.   FUNGAL GENETICS AND BIOLOGY

Two cation transporters Ena1 and Nha1 cooperatively modulate ion homeostasis, antifungal drug resistance, and virulence of Cryptococcus neoformans via the HOG pathway

(2012) Kwang-Woo Jung et al.   FUNGAL GENETICS AND BIOLOGY

Response to Hyperosmotic Stress

(2012) H. Saito et al.   GENETICS

Reduced TOR signaling sustains hyphal development in Candida albicans by lowering Hog1 basal activity

(2012) Chang Su et al.   MOLECULAR BIOLOGY OF THE CELL

HOG-MAPK Signaling Regulates the Adaptive Responses of Aspergillus fumigatus to Thermal Stress and Other Related Stress

(2012) Yajuan Ji et al.   MYCOPATHOLOGIA

The Two-Component Sensor Kinase TcsC and Its Role in Stress Resistance of the Human-Pathogenic Mold Aspergillus fumigatus

(2012) Allison McCormick et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Targeting the Oxidative Stress Response System of Fungi with Redox-Potent Chemosensitizing Agents

(2012) Jong H. Kim et al.   Frontiers in Microbiology

Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase

(2011) Alexandre Vendrell et al.   EMBO REPORTS

Multiple Roles of Ypd1 Phosphotransfer Protein in Viability, Stress Response, and Virulence Factor Regulation in Cryptococcus neoformans

(2011) Jang-Won Lee et al.   EUKARYOTIC CELL

The Hog1 Mitogen-Activated Protein Kinase Mediates a Hypoxic Response inSaccharomyces cerevisiae

(2011) Mark J. Hickman et al.   GENETICS

MAPKKK-independent Regulation of the Hog1 Stress-activated Protein Kinase inCandida albicans

(2011) Jill Cheetham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel functional assay for fungal histidine kinases group III reveals the role of HAMP domains for fungicide sensitivity

(2011) Anna Buschart et al.   JOURNAL OF BIOTECHNOLOGY

Hrk1 Plays Both Hog1-Dependent and -Independent Roles in Controlling Stress Response and Antifungal Drug Resistance in Cryptococcus neoformans

(2011) Seo-Young Kim et al.   PLoS One

Interaction between the Candida albicans High-Osmolarity Glycerol (HOG) Pathway and the Response to Human β-Defensins 2 and 3

(2010) Silvia Argimón et al.   EUKARYOTIC CELL

Stress signalling to fungal stress-activated protein kinase pathways

(2010) Deborah A. Smith et al.   FEMS MICROBIOLOGY LETTERS

Comparative Transcriptome Analysis of the CO2 Sensing Pathway Via Differential Expression of Carbonic Anhydrase in Cryptococcus neoformans

(2010) M. S. Kim et al.   GENETICS

Thioredoxin Regulates Multiple Hydrogen Peroxide-Induced Signaling Pathways in Candida albicans

(2010) A. da Silva Dantas et al.   MOLECULAR AND CELLULAR BIOLOGY

Phylogenetic diversity of stress signaling pathways in fungi

(2009) Elissavet Nikolaou et al.   BMC EVOLUTIONARY BIOLOGY

Multilayered control of gene expression by stress-activated protein kinases

(2009) Eulàlia de Nadal et al.   EMBO JOURNAL

Remodeling of Global Transcription Patterns ofCryptococcus neoformansGenes Mediated by the Stress-Activated HOG Signaling Pathways

(2009) Young-Joon Ko et al.   EUKARYOTIC CELL

Exposure to caspofungin activates Cap and Hog pathways inCandida albicans

(2009) Judy Kelly et al.   MEDICAL MYCOLOGY

The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans

(2009) Rebeca Alonso-Monge et al.   MICROBIOLOGY-SGM

Glucose Promotes Stress Resistance in the Fungal Pathogen Candida albicans

(2009) Alexandra Rodaki et al.   MOLECULAR BIOLOGY OF THE CELL

Master and Commander in Fungal Pathogens: the Two-Component System and the HOG Signaling Pathway

(2008) Yong-Sun Bahn   EUKARYOTIC CELL

The MAP kinase-activated protein kinase Rck2p plays a role in rapamycin sensitivity inSaccharomyces cerevisiaeandCandida albicans

(2008) Xichuan Li et al.   FEMS YEAST RESEARCH

Regulation of the Candida albicans Cell Wall Damage Response by Transcription Factor Sko1 and PAS Kinase Psk1

(2008) Jason M. Rauceo et al.   MOLECULAR BIOLOGY OF THE CELL

Stress resistance and signal fidelity independent of nuclear MAPK function

(2008) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA