Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway

Impaired Intestinal Permeability Contributes to Ongoing Bowel Symptoms in Patients With Inflammatory Bowel Disease and Mucosal Healing

(2017) Jeff Chang et al.   GASTROENTEROLOGY

Understanding and Preventing the Global Increase of Inflammatory Bowel Disease

(2017) Gilaad G. Kaplan et al.   GASTROENTEROLOGY

NK1.1− CD4+ NKG2D+ T cells suppress DSS-induced colitis in mice through production of TGF-β

(2017) Xingxing Qian et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome

(2017) Viola Neudecker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Formononetin inhibits human bladder cancer cell proliferation and invasiveness via regulation of miR-21 and PTEN

(2017) Yiying Wu et al.   Food & Function

Development of a novel model of hypertriglyceridemic acute pancreatitis in mice

(2017) Yiyuan Pan et al.   Scientific Reports

Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies

(2017) Duk Hwan Kim et al.   Immune Network

Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity

(2017) Fen Jin et al.   PLoS One

Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice

(2016) Guizhen Qiu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Reduced Mucosa-associated Butyricicoccus Activity in Patients with Ulcerative Colitis Correlates with Aberrant Claudin-1 Expression

(2016) Sarah Devriese et al.   Journal of Crohns & Colitis

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3

(2016) Hui Song et al.   Nature Communications

Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice

(2016) Guotao Lu et al.   Biomed Research International

Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents

(2015) Rodrigo Lima Cavendish et al.   JOURNAL OF ETHNOPHARMACOLOGY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

NLRP3 inflammasome and its inhibitors: a review

(2015) Bo-Zong Shao et al.   Frontiers in Pharmacology

Mucosal Barrier, Bacteria and Inflammatory Bowel Disease: Possibilities for Therapy

(2014) Yvette Merga et al.   DIGESTIVE DISEASES

NLRP3 gene is associated with ulcerative colitis (UC), but not Crohn’s disease (CD), in Chinese Han population

(2014) Hong-xin Zhang et al.   INFLAMMATION RESEARCH

Formononetin protects TBI rats against neurological lesions and the underlying mechanism

(2014) Zhengzhao Li et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Marine Hydroquinone Zonarol Prevents Inflammation and Apoptosis in Dextran Sulfate Sodium-Induced Mice Ulcerative Colitis

(2014) Sohsuke Yamada et al.   PLoS One

Sealing the Broken Barrier in IBD: Intestinal Permeability, Epithelial Cells and Junctions

(2013) Walter Fries et al.   CURRENT DRUG TARGETS

Formononetin Inhibited the Inflammation of LPS-Induced Acute Lung Injury in Mice Associated with Induction of PPAR Gamma Expression

(2013) Zhanqiang Ma et al.   INFLAMMATION

Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis

(2013) Weicheng Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

The NLRP3 Inflammasome in Alzheimer’s Disease

(2013) Meng-Shan Tan et al.   MOLECULAR NEUROBIOLOGY

Delivery of IL-12p40 ameliorates DSS-induced colitis by suppressing IL-17A expression and inflammation in the intestinal mucosa

(2012) Doo-Jin Kim et al.   CLINICAL IMMUNOLOGY

Toll-like receptors, the NLRP3 inflammasome and interleukin-1β in the development and progression of type 1 diabetes

(2012) Ellen K. Grishman et al.   PEDIATRIC RESEARCH

Differential expression of occludin in patients with ulcerative colitis and healthy controls

(2011) Jesús K. Yamamoto-Furusho et al.   INFLAMMATORY BOWEL DISEASES

The Inflammasomes

(2010) Kate Schroder et al.   CELL

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

The genetics of NOD-like receptors in Crohn's disease

(2010) J. R. Fraser Cummings et al.   TISSUE ANTIGENS