An NLRP3 inflammasome-triggered cytokine storm contributes to Streptococcal toxic shock-like syndrome (STSLS)

Dysregulated hemolysin liberates bacterial outer membrane vesicles for cytosolic lipopolysaccharide sensing

(2018) Shouwen Chen et al.   PLoS Pathogens

High-affinity caspase-4 binding to LPS presented as high molecular mass aggregates or in outer membrane vesicles

(2017) Mark A Wacker et al.   Innate Immunity

Selection of Potential Virulence Factors Contributing to Streptococcus suis Serotype 2 Penetration into the Blood-Brain Barrier in an In Vitro Co-Culture Model

(2017) Hongtao Liu et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

HP1330 Contributes to Streptococcus suis Virulence by Inducing Toll-Like Receptor 2- and ERK1/2-Dependent Pro-inflammatory Responses and Influencing In Vivo S. suis Loads

(2017) Qiang Zhang et al.   Frontiers in Immunology

Group A streptococcal M protein activates the NLRP3 inflammasome

(2017) J. Andrés Valderrama et al.   Nature Microbiology

The cardiac glycoside ouabain activates NLRP3 inflammasomes and promotes cardiac inflammation and dysfunction

(2017) Motoi Kobayashi et al.   PLoS One

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

(2016) Sivapriya Kailasan Vanaja et al.   CELL

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

(2016) A. Rialdi et al.   SCIENCE

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

Efficient suilysin-mediated invasion and apoptosis in porcine respiratory epithelial cells after streptococcal infection under air-liquid interface conditions

(2016) Fandan Meng et al.   Scientific Reports

Effects of Suilysin on Streptococcus suis-Induced Platelet Aggregation

(2016) Shengwei Zhang et al.   Frontiers in Cellular and Infection Microbiology

Suilysin Stimulates the Release of Heparin Binding Protein from Neutrophils and Increases Vascular Permeability in Mice

(2016) Shaolong Chen et al.   Frontiers in Microbiology

Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+Efflux

(2015) Mausita Karmakar et al.   JOURNAL OF IMMUNOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

(2015) Cierra N. Casson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

(2015) Annette Ives et al.   Nature Communications

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

(2015) Sean P. Cullen et al.   Cell Reports

Targeting TREM-1 Signaling in the Presence of Antibiotics is Effective Against Streptococcal Toxic-Shock-Like Syndrome (STSLS) Caused by Streptococcus suis

(2015) Chao Yang et al.   Frontiers in Cellular and Infection Microbiology

A novel pro-inflammatory protein of Streptococcus suis 2 induces the Toll-like receptor 2-dependent expression of pro-inflammatory cytokines in RAW 264.7 macrophages via activation of ERK1/2 pathway

(2015) Qiang Zhang et al.   Frontiers in Microbiology

Deregulated Balance of Omega-6 and Omega-3 Polyunsaturated Fatty Acids following Infection by the Zoonotic Pathogen Streptococcus suis

(2014) Claude Lachance et al.   INFECTION AND IMMUNITY

Increased production of suilysin contributes to invasive infection of the Streptococcus suis strain 05ZYH33

(2014) ZHENGXIN HE et al.   Molecular Medicine Reports

Assessment of the pathogenesis of Streptococcus suis type 2 infection in piglets for understanding streptococcal toxic shock-like syndrome, meningitis, and sequelae

(2014) Yuhai Bi et al.   VETERINARY MICROBIOLOGY

Suilysin remodels the cytoskeletons of human brain microvascular endothelial cells by activating RhoA and Rac1 GTPase

(2014) Qingyu Lv et al.   Protein & Cell

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Nlrp-3-Driven Interleukin 17 Production by γδT Cells Controls Infection Outcomes during Staphylococcus aureus Surgical Site Infection

(2013) Belinda M. Maher et al.   INFECTION AND IMMUNITY

Exacerbated Type II Interferon Response Drives Hypervirulence and Toxic Shock by an Emergent Epidemic Strain of Streptococcus suis

(2013) Claude Lachance et al.   INFECTION AND IMMUNITY

The Contribution of Suilysin to the Pathogenesis of Streptococcus suis Meningitis

(2013) Dan Takeuchi et al.   JOURNAL OF INFECTIOUS DISEASES

Identification and Characterization of a Novel Hemolysis-Related Gene in Streptococcus suis Serotype 2

(2013) Jun-xi Zheng et al.   PLoS One

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

The genetically modified suilysin, rSLYP353L, provides a candidate vaccine that suppresses proinflammatory response and reduces fatality following infection with Streptococcus suis

(2013) Huamao Du et al.   VACCINE

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

HP0197 Contributes to CPS Synthesis and the Virulence of Streptococcus suis via CcpA

(2012) Anding Zhang et al.   PLoS One

Attenuation of Streptococcus suis virulence by the alteration of bacterial surface architecture

(2012) Youjun Feng et al.   Scientific Reports

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia

(2011) M. Witzenrath et al.   JOURNAL OF IMMUNOLOGY

Critical Role for Streptococcussuis Cell Wall Modifications and Suilysin in Resistance to Complement-Dependent Killing by Dendritic Cells

(2011) Marie-Pier Lecours et al.   JOURNAL OF INFECTIOUS DISEASES

GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2

(2011) Ming Li et al.   MOLECULAR MICROBIOLOGY

Interferon Gamma-Dependent Intestinal Pathology Contributes to the Lethality in Bacterial Superantigen-Induced Toxic Shock Syndrome

(2011) Ashenafi Y. Tilahun et al.   PLoS One

The role of toll-like receptors in the pathogenesis of Streptococcus suis

(2011) Han Zheng et al.   VETERINARY MICROBIOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

(2010) Edel A. McNeela et al.   PLoS Pathogens

Crystal structure of cytotoxin protein suilysin from Streptococcus suis

(2010) Lingfeng Xu et al.   Protein & Cell

Streptococcus suis:An Emerging Human Pathogen

(2009) Heiman F. L. Wertheim et al.   CLINICAL INFECTIOUS DISEASES

Roles of IKK-β, IRF1, and p65 in the Activation of Chemokine Genes by Interferon-γ

(2009) David B. Shultz et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Comparison of the Susceptibilities of C57BL/6 and A/J Mouse Strains to Streptococcus suis Serotype 2 Infection

(2008) M. d. l. C. Dominguez-Punaro et al.   INFECTION AND IMMUNITY

D-Alanylation of Lipoteichoic Acid Contributes to the Virulence of Streptococcus suis

(2008) N. Fittipaldi et al.   INFECTION AND IMMUNITY

Clinical, Experimental, and Genomic Differences between Intermediately Pathogenic, Highly Pathogenic, and EpidemicStreptococcus suis

(2008) Changyun Ye et al.   JOURNAL OF INFECTIOUS DISEASES

Streptococcus suis: An Emerging Human Threat

(2008) Mariela Segura   JOURNAL OF INFECTIOUS DISEASES