Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome

Combined quantification of intracellular (phospho-)proteins and transcriptomics from fixed single cells

(2019) Jan. P. Gerlach et al.   Scientific Reports

Genomic Imprinting and Physiological Processes in Mammals

(2019) Valter Tucci et al.   CELL

Placental DNA Methylation Adaptation to Maternal Glycemic Response in Pregnancy

(2018) Andres Cardenas et al.   DIABETES

Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation

(2018) Emilie Abraham et al.   ENVIRONMENT INTERNATIONAL

Prenatal exposure to persistent organic pollutants and methylation of LINE-1 and imprinted genes in placenta: A CHECK cohort study

(2018) Sujin Kim et al.   ENVIRONMENT INTERNATIONAL

Cadmium-Associated Differential Methylation throughout the Placental Genome: Epigenome-Wide Association Study of Two U.S. Birth Cohorts

(2018) Todd M. Everson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cumulative lifetime maternal stress and epigenome-wide placental DNA methylation in the PRISM cohort

(2018) Kelly J. Brunst et al.   Epigenetics

Placental CpG methylation of infants born extremely preterm predicts cognitive impairment later in life

(2018) Sloane K. Tilley et al.   PLoS One

Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy

(2018) Jacqueline Alexander et al.   PLoS One

Air pollution during pregnancy and placental adaptation in the levels of global DNA methylation

(2018) Zhila Maghbooli et al.   PLoS One

Noninvasive reconstruction of placental methylome from maternal plasma DNA: Potential for prenatal testing and monitoring

(2018) Kun Sun et al.   PRENATAL DIAGNOSIS

Time- and sex-dependent associations between prenatal alcohol exposure and placental global DNA methylation

(2018) Yuk Jing Loke et al.   Epigenomics

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

(2018) Stephen J. Clark et al.   Nature Communications

Exposure to Phthalate, an Endocrine Disrupting Chemical, Alters the First Trimester Placental Methylome and Transcriptome in Women

(2018) N. M. Grindler et al.   Scientific Reports

H3K27 acetylation and gene expression analysis reveals differences in placental chromatin activity in fetal growth restriction

(2018) N. D. Paauw et al.   Clinical Epigenetics

Epigenetic regulation of placental gene expression in transcriptional subtypes of preeclampsia

(2018) Katherine Leavey et al.   Clinical Epigenetics

Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta 

(2018) Yawei Liu et al.   CELL RESEARCH

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

(2018) Sandra Haider et al.   Stem Cell Reports

909: Methylation profile of circulating cfDNA at term demonstrates relatively low placental contribution to hypomethylated cfDNA

(2018) Mohak Mhatre et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Bisphenol-A impairs cellular function and alters DNA methylation of stress pathway genes in first trimester trophoblast cells

(2018) Sanjay Basak et al.   REPRODUCTIVE TOXICOLOGY

DNA methylation profiling of acute chorioamnionitis-associated placentas and fetal membranes: insights into epigenetic variation in spontaneous preterm births

(2018) Chaini Konwar et al.   Epigenetics & Chromatin

A single-cell survey of the human first-trimester placenta and decidua

(2018) Hemant Suryawanshi et al.   Science Advances

The early pregnancy placenta foreshadows DNA methylation alterations of solid tumors

(2017) Akpéli V. Nordor et al.   Epigenetics

Variable DAXX gene methylation is a common feature of placental trophoblast differentiation, preeclampsia, and response to hypoxia

(2017) Boris Novakovic et al.   FASEB JOURNAL

Estimation of a significance threshold for epigenome-wide association studies

(2017) Ayden Saffari et al.   GENETIC EPIDEMIOLOGY

Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface

(2017) Mihaela Pavličev et al.   GENOME RESEARCH

Mining DNA methylation alterations towards a classification of placental pathologies

(2017) Samantha L Wilson et al.   HUMAN MOLECULAR GENETICS

H3K27me3 dynamics dictate evolving uterine states in pregnancy and parturition

(2017) Patrice Nancy et al.   JOURNAL OF CLINICAL INVESTIGATION

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

(2017) Zachary D. Smith et al.   NATURE

Early- and late-onset preeclampsia and the tissue-specific epigenome of the placenta and newborn

(2017) Emilie M. Herzog et al.   PLACENTA

The cytotrophoblastic shell and complications of pregnancy

(2017) Graham J. Burton et al.   PLACENTA

Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics

(2017) Jason C. H. Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prenatal Growth Patterns and Birthweight Are Associated With Differential DNA Methylation and Gene Expression of Cardiometabolic Risk Genes in Human Placentas: A Discovery-Based Approach

(2017) Pao-Yang Chen et al.   Reproductive Sciences

BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma

(2017) Darlene A. Kertes et al.   Clinical Epigenetics

The placenta as a model for understanding the origin and evolution of vertebrate organs

(2017) Oliver W. Griffith et al.   Nature Ecology & Evolution

Alterations in the placental methylome with maternal obesity and evidence for metabolic regulation

(2017) Kohzoh Mitsuya et al.   PLoS One

Allele-Specific Methylome and Transcriptome Analysis Reveals Widespread Imprinting in the Human Placenta

(2016) Hirotaka Hamada et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gestational Age Assessment by Methylation and Size Profiling of Maternal Plasma DNA: A Feasibility Study

(2016) Peiyong Jiang et al.   CLINICAL CHEMISTRY

Maternal residential proximity to major roadways, birth weight, and placental DNA methylation

(2016) Samantha L. Kingsley et al.   ENVIRONMENT INTERNATIONAL

Epigenome-Wide Assessment of DNA Methylation in the Placenta and Arsenic Exposure in the New Hampshire Birth Cohort Study (USA)

(2016) Benjamin B. Green et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Regions of variable DNA methylation in human placenta associated with newborn neurobehavior

(2016) Alison G. Paquette et al.   Epigenetics

Pervasive polymorphic imprinted methylation in the human placenta

(2016) Courtney W. Hanna et al.   GENOME RESEARCH

Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy

(2016) Eva Morales et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

DNA methylation mediated up-regulation ofTERRAnon-coding RNA is coincident with elongated telomeres in the human placenta

(2016) Boris Novakovic et al.   MOLECULAR HUMAN REPRODUCTION

Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity

(2016) Christof Angermueller et al.   NATURE METHODS

Placental expression of DNA methyltransferase 1 (DNMT1): Gender-specific relation with human placental growth

(2016) A. Mukhopadhyay et al.   PLACENTA

A distant trophoblast-specific enhancer controls HLA-G expression at the maternal–fetal interface

(2016) Leonardo M. R. Ferreira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Variable Methylation Potential in Preterm Placenta: Implication for Epigenetic Programming of the Offspring

(2016) Vinita V. Khot et al.   Reproductive Sciences

Profiling placental and fetal DNA methylation in human neural tube defects

(2016) E. Magda Price et al.   Epigenetics & Chromatin

Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy

(2016) Andrew C. Nelson et al.   Nature Communications

Placental Hypomethylation Is More Pronounced in Genomic Loci Devoid of Retroelements

(2016) Aniruddha Chatterjee et al.   G3-Genes Genomes Genetics

Genome-wide placental DNA methylation analysis of severely growth-discordant monochorionic twins reveals novel epigenetic targets for intrauterine growth restriction

(2016) Maian Roifman et al.   Clinical Epigenetics

Assessment of global DNA methylation in the first trimester fetal tissues exposed to maternal cigarette smoking

(2016) Svetlana Fa et al.   Clinical Epigenetics

Increased global placental DNA methylation levels are associated with gestational diabetes

(2016) C. Reichetzeder et al.   Clinical Epigenetics

Placental methylome analysis from a prospective autism study

(2016) Diane I. Schroeder et al.   Molecular Autism

Third trimester phthalate exposure is associated with DNA methylation of growth-related genes in human placenta

(2016) Yan Zhao et al.   Scientific Reports

Epigenetic regulation of human placental function and pregnancy outcome: considerations for causal inference

(2015) Vania Januar et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Power and sample size estimation for epigenome-wide association scans to detect differential DNA methylation

(2015) Pei-Chien Tsai et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors

(2015) Christian Schmidl et al.   NATURE METHODS

Extensive load of somatic CNVs in the human placenta

(2015) Laura Kasak et al.   Scientific Reports

Whole genome bisulfite sequencing of cell-free DNA and its cellular contributors uncovers placenta hypomethylated domains

(2015) Taylor J Jensen et al.   GENOME BIOLOGY

Epigenetics and Preeclampsia: Defining Functional Epimutations in the Preeclamptic Placenta Related to the TGF-β Pathway

(2015) Elizabeth Martin et al.   PLoS One

The DNA methylation landscape of human early embryos

(2014) Hongshan Guo et al.   NATURE

Retrotransposon Hypomethylation in Melanoma and Expression of a Placenta-Specific Gene

(2014) Erin C. Macaulay et al.   PLoS One

Chromatin state dynamics during blood formation

(2014) D. Lara-Astiaso et al.   SCIENCE

DNMT1 and AIM1 Imprinting in human placenta revealed through a genome-wide screen for allele-specific DNA methylation

(2013) Radhika Das et al.   BMC GENOMICS

Hypoxia alters the epigenetic profile in cultured human placental trophoblasts

(2013) Ryan K.C. Yuen et al.   Epigenetics

The human placenta methylome

(2013) D. I. Schroeder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

The ever growing complexity of placental epigenetics – Role in adverse pregnancy outcomes and fetal programming

(2012) B. Novakovic et al.   PLACENTA

Evidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors

(2011) Boris Novakovic et al.   BMC GENOMICS

Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas

(2011) Carolyn E. Banister et al.   Epigenetics

Placenta-specific Expression of the Interleukin-2 (IL-2) Receptor β Subunit from an Endogenous Retroviral Promoter

(2011) Carla J. Cohen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypomethylation of functional retrotransposon-derived genes in the human placenta

(2011) Erin C. Macaulay et al.   MAMMALIAN GENOME

Wide-ranging DNA methylation differences of primary trophoblast cell populations and derived cell lines: implications and opportunities for understanding trophoblast function†

(2011) Boris Novakovic et al.   MOLECULAR HUMAN REPRODUCTION

Evaluation of the Infinium Methylation 450K technology

(2011) Sarah Dedeurwaerder et al.   Epigenomics

The Immune System in Pregnancy: A Unique Complexity

(2010) Gil Mor et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia

(2010) Ryan KC Yuen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

DNA Methylation-mediated Down-regulation of DNA Methyltransferase-1 (DNMT1) Is Coincident with, but Not Essential for, Global Hypomethylation in Human Placenta

(2010) Boris Novakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential DNA Methylation as a Tool for Noninvasive Prenatal Diagnosis (NIPD) of X Chromosome Aneuploidies

(2010) Floriana Della Ragione et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Distinct Patterns of Gene-Specific Methylation in Mammalian Placentas: Implications for Placental Evolution and Function

(2010) H.K. Ng et al.   PLACENTA

Inactive X chromosome-specific reduction in placental DNA methylation

(2009) Allison M. Cotton et al.   HUMAN MOLECULAR GENETICS

The Placenta and Intrauterine Programming

(2008) A. L. Fowden et al.   JOURNAL OF NEUROENDOCRINOLOGY

Specific tumour-associated methylation in normal human term placenta and first-trimester cytotrophoblasts

(2008) B. Novakovic et al.   MOLECULAR HUMAN REPRODUCTION

Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma

(2008) R. W. K. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA