Peroxisome Proliferator-Activated Receptor γ and PGC-1α in Cancer: Dual Actions as Tumor Promoter and Suppressor

Activation of peroxisome proliferator-activated receptor gamma in mammary epithelial cells upregulates the expression of tumor suppressor Cyld to mediate growth inhibition and anti-inflammatory effects

(2017) Athanasios Pseftogas et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription

(2017) Cecilia Patitucci et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel interaction of PAK4 with PPARγ to regulate Nox1 and radiation-induced epithelial-to-mesenchymal transition in glioma

(2017) D Kesanakurti et al.   ONCOGENE

Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer

(2017) Yves Lecarpentier et al.   PPAR Research

Constitutive expression of PPARγ inhibits proliferation and migration of gastric cancer cells and down-regulates Wnt/β-Catenin signaling pathway downstream target genes TERT and ENAH

(2016) Fang Guo et al.   GENE

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis

(2016) Chi Luo et al.   NATURE

The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

(2016) Veronica Torrano et al.   NATURE CELL BIOLOGY

Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progression

(2016) Daniela Rovito et al.   Oncotarget

Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter

(2016) Farzad S. Forootan et al.   Oncotarget

PPARγ: Welcoming the New Kid on the CML Stem Cell Block

(2015) Beth Apsel Winger et al.   CANCER CELL

Overexpression of PGC-1α enhances cell proliferation and tumorigenesis of HEK293 cells through the upregulation of Sp1 and Acyl-CoA binding protein

(2015) SUNG-WON SHIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inherited cylindromas: lessons from a rare tumour

(2015) Neil Rajan et al.   LANCET ONCOLOGY

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

(2015) Stéphane Prost et al.   NATURE

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

Targeting Stem Cells in Chronic Myeloid Leukemia with a PPAR-γ Agonist

(2015) Josephine M. Egan   NEW ENGLAND JOURNAL OF MEDICINE

Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α

(2015) Neri Minsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis

(2015) Xiaowen Song et al.   Oncotarget

Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma

(2015) Edward L. LaGory et al.   Cell Reports

PKD1 Phosphorylation-Dependent Degradation of SNAIL by SCF-FBXO11 Regulates Epithelial-Mesenchymal Transition and Metastasis

(2014) Hanqiu Zheng et al.   CANCER CELL

RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis

(2014) W Chen et al.   CELL DEATH AND DIFFERENTIATION

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

(2014) K. T. Pate et al.   EMBO JOURNAL

The combinatory effects of PPAR-γ agonist and survivin inhibition on the cancer stem-like phenotype and cell proliferation in bladder cancer cells

(2014) YANG WANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PPARγ and RXR Ligands Disrupt the Inflammatory Cross-talk in the Hypoxic Breast Cancer Stem Cells Niche

(2014) Alessio Papi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proteomic signatures associated with p53 mutational status in lung adenocarcinoma

(2014) Ayumu Taguchi et al.   PROTEOMICS

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

Small Molecule Agonists of PPAR-γ Exert Therapeutic Effects in Esophageal Cancer

(2013) Hiroshi Sawayama et al.   CANCER RESEARCH

The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance

(2013) Florian A. Siebzehnrubl et al.   EMBO Molecular Medicine

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

PPARγ maintains ERBB2-positive breast cancer stem cells

(2013) X Wang et al.   ONCOGENE

PPARγ E3 ubiquitin ligase regulates MUC1-C oncoprotein stability

(2013) Y Hou et al.   ONCOGENE

Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch

(2013) J B Tennakoon et al.   ONCOGENE

4-O-methylhonokiol, a PPARγ agonist, inhibits prostate tumour growth: p21-mediated suppression of NF-κB activity

(2012) NJ Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

The MUC1-C Oncoprotein Binds to the BH3 Domain of the Pro-apoptotic BAX Protein and Blocks BAX Function

(2012) Rehan Ahmad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity

(2012) A D Whale et al.   ONCOGENE

MENA Is a Transcriptional Target of the Wnt/Beta-Catenin Pathway

(2012) Ayaz Najafov et al.   PLoS One

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer

(2012) Geoffrey D. Girnun   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Role of Peroxisome Proliferator-Activated Receptors in Colorectal Cancer

(2012) Joo-In Park et al.   PPAR Research

PPARγ is an E3 ligase that induces the degradation of NFκB/p65

(2012) Yongzhong Hou et al.   Nature Communications

Aberrant Cell Proliferation by Enhanced Mitochondrial Biogenesis via mtTFA in Arsenical Skin Cancers

(2011) Chih-Hung Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

PGC1  Promotes Tumor Growth by Inducing Gene Expression Programs Supporting Lipogenesis

(2011) K. Bhalla et al.   CANCER RESEARCH

MUC1 Protein Expression in Tumor Cells Regulates Transcription of Proinflammatory Cytokines by Forming a Complex with Nuclear Factor-κB p65 and Binding to Cytokine Promoters

(2011) Sandra Cascio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinase Suppressor of Ras 1 (KSR1) Regulates PGC1  and Estrogen-Related Receptor   To Promote Oncogenic Ras-Dependent Anchorage-Independent Growth

(2011) K. W. Fisher et al.   MOLECULAR AND CELLULAR BIOLOGY

PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic Stress

(2011) Nirmalya Sen et al.   MOLECULAR CELL

Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels

(2011) Xiao Wang et al.   Molecular Oncology

MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells

(2011) J-J Lee et al.   ONCOGENE

Peroxisome proliferator-activated receptor-  coactivator 1-  (PGC1 ) is a metabolic regulator of intestinal epithelial cell fate

(2011) I. D'Errico et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop

(2011) R. Ahmad et al.   Science Signaling

Suppression of NF-κB and GSK-3β is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone

(2010) Jung Ok Ban et al.   CHEMICO-BIOLOGICAL INTERACTIONS

p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients

(2010) M. K. Y. Siu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC-1  regulates a HIF2 -dependent switch in skeletal muscle fiber types

(2010) K. A. Rasbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Influence of Tumor-Host Interactions in the Stromal Cell-Derived Factor-1/CXCR4 Ligand/Receptor Axis in Determining Metastatic Risk in Breast Cancer

(2009) Saima Hassan et al.   AMERICAN JOURNAL OF PATHOLOGY

Pak protein kinases and their role in cancer

(2009) Bettina Dummler et al.   CANCER AND METASTASIS REVIEWS

MUC1-C Oncoprotein Functions as a Direct Activator of the Nuclear Factor- B p65 Transcription Factor

(2009) R. Ahmad et al.   CANCER RESEARCH

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

(2009) David Komander et al.   EMBO REPORTS

Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Interacts with the Androgen Receptor (AR) and Promotes Prostate Cancer Cell Growth by Activating the AR

(2009) Masaki Shiota et al.   MOLECULAR ENDOCRINOLOGY

PGC-1  is coupled to HIF-1 -dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells

(2009) K. A. O'Hagan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells

(2008) Yekaterina Y Zaytseva et al.   Molecular Cancer

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE