The Role of Estrogen in Brain and Cognitive Aging

A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity

(2018) Jerri M. Rook et al.   ACS Chemical Neuroscience

A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer's disease

(2018) E. Croteau et al.   EXPERIMENTAL GERONTOLOGY

Preclinical to Human Translational Pharmacology of the Novel M1Positive Allosteric Modulator MK-7622

(2018) Jason M. Uslaner et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effects of Sex Hormones and Age on Brain Volume in Post-Menopausal Women

(2018) Gwang-Won Kim et al.   Journal of Sexual Medicine

Comparison of transitional vs surgical menopause on monoamine and amino acid levels in the rat brain

(2018) Tao Long et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Molecular mechanisms involved in the protective actions of Selective Estrogen Receptor Modulators in brain cells

(2018) Eliana Baez-Jurado et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Estrogen and Alzheimer's disease: Still an attractive topic despite disappointment from early clinical results

(2017) Sara Merlo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dopaminergic contributions to working memory-related brain activation in postmenopausal women

(2017) Julie A. Dumas et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Estrogen enhances hippocampal gray-matter volume in young and older postmenopausal women: a prospective dose-response study

(2017) Kimberly Albert et al.   NEUROBIOLOGY OF AGING

Estrogens in Male Physiology

(2017) Paul S. Cooke et al.   PHYSIOLOGICAL REVIEWS

On the path to 2025: understanding the Alzheimer’s disease continuum

(2017) Paul S. Aisen et al.   Alzheimers Research & Therapy

Perimenopause and emergence of an Alzheimer’s bioenergetic phenotype in brain and periphery

(2017) Lisa Mosconi et al.   PLoS One

Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256

(2016) Michael D. Grannan et al.   ACS Chemical Neuroscience

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Menopause and Parkinson’s disease. Interaction between estrogens and brain renin-angiotensin system in dopaminergic degeneration

(2016) Jose L. Labandeira-Garcia et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition

(2016) Kejal Kantarci et al.   JOURNAL OF ALZHEIMERS DISEASE

Estrogen Restores Multisynaptic Boutons in the Dorsolateral Prefrontal Cortex while Promoting Working Memory in Aged Rhesus Monkeys

(2016) Y. Hara et al.   JOURNAL OF NEUROSCIENCE

Effect of Ovarian Hormone Therapy on Cognition in the Aged Female Rhesus Macaque

(2016) Steven G. Kohama et al.   JOURNAL OF NEUROSCIENCE

17 -Estradiol and Agonism of G-protein-Coupled Estrogen Receptor Enhance Hippocampal Memory via Different Cell-Signaling Mechanisms

(2016) J. Kim et al.   JOURNAL OF NEUROSCIENCE

Alzheimer’s disease, apolipoprotein E and hormone replacement therapy

(2016) H. Depypere et al.   MATURITAS

Neuroactive gonadal drugs for neuroprotection in male and female models of Parkinson's disease

(2016) Nadhir Litim et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Inhibitory effect of estrogen receptor beta on P2X3 receptors during inflammation in rats

(2016) Qian Jiang et al.   Purinergic Signalling

Tamoxifen accelerates the repair of demyelinated lesions in the central nervous system

(2016) Ginez A. Gonzalez et al.   Scientific Reports

Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice

(2015) R. W. Gould et al.   ACS Chemical Neuroscience

Prolonged androgen deprivation may influence the autoregulation of estrogen receptors in the brain and pelvic floor muscles of male rats

(2015) Erik Wibowo et al.   BEHAVIOURAL BRAIN RESEARCH

Estradiol rapidly modulates synaptic plasticity of hippocampal neurons: Involvement of kinase networks

(2015) Yoshitaka Hasegawa et al.   BRAIN RESEARCH

A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release

(2015) Victor Briz et al.   JOURNAL OF CELL BIOLOGY

Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway

(2015) Yasuhiro Ishihara et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Poor sleep in relation to natural menopause

(2015) Ellen W. Freeman et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Adjunctive raloxifene treatment improves attention and memory in men and women with schizophrenia

(2015) T W Weickert et al.   MOLECULAR PSYCHIATRY

Critical period for dopaminergic neuroprotection by hormonal replacement in menopausal rats

(2015) Ana I. Rodriguez-Perez et al.   NEUROBIOLOGY OF AGING

The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity

(2015) Fei Yin et al.   NEUROBIOLOGY OF AGING

Effects of estrogen and testosterone treatment on serotonin transporter binding in the brain of surgically postmenopausal women – a PET study

(2015) Hristina Jovanovic et al.   NEUROIMAGE

Selective Estrogen Receptor Modulation Increases Hippocampal Activity during Probabilistic Association Learning in Schizophrenia

(2015) Jochen Kindler et al.   NEUROPSYCHOPHARMACOLOGY

Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model

(2015) A Ghoshal et al.   NEUROPSYCHOPHARMACOLOGY

Estrogen, Stress, and Depression

(2015) Paul Newhouse et al.   JAMA Psychiatry

Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression

(2015) Peter J. Schmidt et al.   JAMA Psychiatry

Activation of G-protein-coupled receptor 30 is sufficient to enhance spatial recognition memory in ovariectomized rats

(2014) Wayne R. Hawley et al.   BEHAVIOURAL BRAIN RESEARCH

Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies

(2014) Joseph Kambeitz et al.   BRITISH JOURNAL OF PSYCHIATRY

Selective Activation of Cholinergic Basal Forebrain Neurons Induces Immediate Sleep-wake Transitions

(2014) Yong Han et al.   CURRENT BIOLOGY

Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep

(2014) Christa J. Van Dort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ovarian hormones promote recovery from sleep deprivation by increasing sleep intensity in middle-aged ovariectomized rats

(2013) Samuel Deurveilher et al.   HORMONES AND BEHAVIOR

The Memory-Enhancing Effects of Hippocampal Estrogen Receptor Activation Involve Metabotropic Glutamate Receptor Signaling

(2013) M. I. Boulware et al.   JOURNAL OF NEUROSCIENCE

The menopause and aging, a comparative perspective

(2013) Caleb E. Finch   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Objective cognitive performance is related to subjective memory complaints in midlife women with moderate to severe vasomotor symptoms

(2013) Lauren L. Drogos et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Female reproductive factors, menopausal hormone use, and Parkinson's disease

(2013) Rui Liu et al.   MOVEMENT DISORDERS

Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys

(2013) Mark G. Baxter et al.   NEUROBIOLOGY OF AGING

Age at surgical menopause influences cognitive decline and Alzheimer pathology in older women

(2013) R. Bove et al.   NEUROLOGY

Tamoxifen Improves Cholinergically Modulated Cognitive Performance in Postmenopausal Women

(2013) Paul Newhouse et al.   NEUROPSYCHOPHARMACOLOGY

What are the physiological estrogens?

(2013) Michael E. Baker   STEROIDS

Expression of angiotensinogen and receptors for angiotensin and prorenin in the monkey and human substantia nigra: an intracellular renin–angiotensin system in the nigra

(2012) Pablo Garrido-Gil et al.   Brain Structure & Function

Hormone therapy, dementia, and cognition: the Women's Health Initiative 10 years on

(2012) P. M. Maki et al.   CLIMACTERIC

Reconciling subjective memory complaints with objective memory performance in the menopausal transition

(2012) Miriam T. Weber et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Estrogen activates matrix metalloproteinases-2 and -9 to increase beta amyloid degradation

(2012) Sara Merlo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cognitive effects of diphenyl diselenide and estradiol treatments in ovariectomized mice

(2012) Juliana Trevisan da Rocha et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Estradiol treatment altered anticholinergic-related brain activation during working memory in postmenopausal women

(2012) Julie A. Dumas et al.   NEUROIMAGE

Cognitive problems in patients on androgen deprivation therapy: A qualitative pilot study

(2012) Lisa M. Wu et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Female rats are more susceptible to the deleterious effects of paradoxical sleep deprivation on cognitive performance

(2011) Vahid Hajali et al.   BEHAVIOURAL BRAIN RESEARCH

Rapid Effects of Estrogen Receptor α and β Selective Agonists on Learning and Dendritic Spines in Female Mice

(2011) Anna Phan et al.   ENDOCRINOLOGY

Galanthamine plus estradiol treatment enhances cognitive performance in aged ovariectomized rats

(2011) R.B. Gibbs et al.   HORMONES AND BEHAVIOR

Early Initiation of Hormone Therapy in Menopausal Women Is Associated with Increased Hippocampal and Posterior Cingulate Cholinergic Activity

(2011) Yolanda R. Smith et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia

(2011) Carrie K Jones et al.   NEUROPSYCHOPHARMACOLOGY

Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation

(2011) J.L. Spencer-Segal et al.   NEUROSCIENCE

Estradiol suppresses recovery of REM sleep following sleep deprivation in ovariectomized female rats

(2011) Michael D. Schwartz et al.   PHYSIOLOGY & BEHAVIOR

Okadaic acid induces tau phosphorylation in SH-SY5Y cells in an estrogen-preventable manner

(2010) Zhang Zhang et al.   BRAIN RESEARCH

GPR30 is positioned to mediate estrogen effects on basal forebrain cholinergic neurons and cognitive performance

(2010) R. Hammond et al.   BRAIN RESEARCH

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Estrogen Therapy and Cognition: A Review of the Cholinergic Hypothesis

(2010) Robert B. Gibbs   ENDOCRINE REVIEWS

Production of Proinflammatory Cytokines and Chemokines During Neuroinflammation: Novel Roles for Estrogen Receptors α and β

(2010) Candice M. Brown et al.   ENDOCRINOLOGY

Increased memory load-related frontal activation after estradiol treatment in postmenopausal women

(2010) Julie A. Dumas et al.   HORMONES AND BEHAVIOR

3 Tesla MRI detects accelerated hippocampal volume reduction in postmenopausal women

(2010) Masami Goto et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Synaptic correlates of memory and menopause in the hippocampal dentate gyrus in rhesus monkeys

(2010) Yuko Hara et al.   NEUROBIOLOGY OF AGING

Estradiol and ERβ agonists enhance recognition memory, and DPN, an ERβ agonist, alters brain monoamines

(2010) Luis F. Jacome et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Elevated Striatal Dopamine Function Linked to Prodromal Signs of Schizophrenia

(2009) Oliver D. Howes et al.   ARCHIVES OF GENERAL PSYCHIATRY

FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease

(2009) Lisa Mosconi et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Chronic treatment with estrogen receptor agonists restores acquisition of a spatial learning task in young ovariectomized rats

(2009) R. Hammond et al.   HORMONES AND BEHAVIOR

Donepezil treatment restores the ability of estradiol to enhance cognitive performance in aged rats: Evidence for the cholinergic basis of the critical period hypothesis

(2009) R.B. Gibbs et al.   HORMONES AND BEHAVIOR

Estrogen Stimulates Degradation of β-Amyloid Peptide by Up-regulating Neprilysin

(2009) Kaiwei Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen Regulation of the Neprilysin Gene Through A Hormone-Responsive Element

(2009) Zhi-Min Xiao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The inflammatory response in the MPTP model of Parkinson’s disease is mediated by brain angiotensin: relevance to progression of the disease

(2009) Belen Joglar et al.   JOURNAL OF NEUROCHEMISTRY

Premature menopause or early menopause: Long-term health consequences

(2009) Lynne T. Shuster et al.   MATURITAS

The Effect of Ovariectomy and Estrogen on Penetrating Brain Arterioles and Blood-Brain Barrier Permeability

(2009) Marilyn J. Cipolla et al.   MICROCIRCULATION

Estrogen therapy: is time of initiation critical for neuroprotection?

(2009) Barbara B. Sherwin   Nature Reviews Endocrinology

Postmenopausal hormone therapy and regional brain volumes: The WHIMS-MRI Study

(2009) S. M. Resnick et al.   NEUROLOGY

Effects of the menopause transition and hormone use on cognitive performance in midlife women

(2009) G. A. Greendale et al.   NEUROLOGY

Reproductive hormone replacement alters sleep in mice

(2009) Ketema N. Paul et al.   NEUROSCIENCE LETTERS

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A randomized controlled trial of add-back estrogen or placebo on cognition in men with prostate cancer receiving an antiandrogen and a gonadotropin-releasing hormone analog

(2009) Rose H. Matousek et al.   PSYCHONEUROENDOCRINOLOGY

NADPH oxidases and angiotensin II receptor signaling

(2008) Abel Martin Garrido et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of estrogen receptor-β regulates hippocampal synaptic plasticity and improves memory

(2008) Feng Liu et al.   NATURE NEUROSCIENCE