Article
Environmental Sciences
Fei Luo, Huaqi Guo, Hengyi Yu, Yan Li, Yan Feng, Yan Wang
Summary: This study found that ER beta plays an important role in inflammation and lung cancer promoted by PM2.5 organic extract (Po). In vitro experiments showed that inhibition of ER beta can reduce IL-6 expression and promote malignant transformation of cells. Animal model experiments demonstrated that Po can induce lung inflammation and injury, and inhibition of ER beta can improve these conditions.
Review
Endocrinology & Metabolism
Xue-Ling Xu, Zheng-Yuan Huang, Kun Yu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This review focuses on the role of ER alpha and ER beta in polycystic ovary syndrome (PCOS), ovarian cancer, and premature ovarian failure (POF), as well as the major challenges of existing therapies. It provides a reference for the treatment of estrogen target tissue ovarian diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Kun Yu, Zheng-Yuan Huang, Xue-Ling Xu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This article discusses the role of estrogen in the female endometrium and its regulatory role through nuclear and membrane-associated receptors. The importance of ERs in maintaining endometrial function is emphasized, and references for treating endometrial diseases are provided.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Aylin Del Moral-Morales, Juan Carlos Gonzalez-Orozco, Ana Maria Hernandez-Vega, Karina Hernandez-Ortega, Karla Mariana Pena-Gutierrez, Ignacio Camacho-Arroyo
Summary: A study found that in human Glioblastomas (GBM), the pro-oncogenic actions of 17 beta-estradiol (E2) are mediated by EZH2, which promotes proliferation, migration, and invasion of GBM cells. Although E2 does not modify EZH2 expression, gene silencing and pharmacological inhibition of EZH2 can block these pro-oncogenic actions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Peng Chen, Bo Li, Ling Ou-Yang
Summary: Estrogen receptors play crucial roles in regulating various physiological processes in humans. Abnormal signaling of these receptors can lead to a wide range of disorders. This review provides an overview of ER alpha, ER beta, and GPER1, highlighting their functions in both health and disease. Additionally, it discusses the potential clinical applications and challenges associated with these receptors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Baocai Xie, Dengke Pan, Huan Liu, Min Liu, Xiaochen Shi, Xinyi Chu, Junfeng Lu, Mengqing Zhu, Bo Xia, Jiangwei Wu
Summary: Diosmetin treatment can reduce body weight and fat mass, improve glucose tolerance and insulin resistance by increasing energy expenditure through enhancing thermogenesis and browning of adipose tissue. Mechanistically, diosmetin acts as an agonist for estrogen receptors (ERs) to elevate their expression in adipose tissue, and the presence of ERs is essential for the metabolic benefits of diosmetin.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Urology & Nephrology
Xin Liu, Yang Yang, Ye Gao, Hengshuai Zhang, Jingzhen Zhu, Xingyou Dong, Jie Xu
Summary: The study found that depletion of estrogen increased urinary frequency, while estrogen receptor beta agonist diarylpropionitrile (DPN) could alleviate this symptom. Additionally, both 17 beta-estradiol and DPN were able to decrease the expression of P2X3 receptors in bladder urothelium cells.
NEUROUROLOGY AND URODYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Agnieszka Anna Rawluszko-Wieczorek, Julia Lipowicz, Marta Nowacka, Kamila Ostrowska, Paulina Pietras, Malgorzata Blatkiewicz, Marcin Rucinski, Pawel Piotr Jagodzinski, Michal Nowicki
Summary: The presence of estrogen receptor beta (ER beta) is inversely correlated with the occurrence of colorectal cancer (CRC), and low expression of ER beta is associated with poorer overall survival of CRC patients. ER beta can inhibit tumorigenesis through various molecular pathways and also has an impact on the hypoxic response in CRC cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Cell Biology
Yuri Park, Yeon Jean Cho, Nuri Sung, Mi Jin Park, Xiaoming Guan, William E. Gibbons, Bert W. O'Malley, Sang Jun Han
Summary: In this study, researchers identified a natural product called oleuropein that selectively inhibits ER beta activity without affecting ER alpha activity, thus suppressing the progression of endometriosis and improving fertility in patients.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Environmental Sciences
Huaqi Guo, Hengyi Yu, Yan Feng, Wei Cheng, Yan Li, Yan Wang
Summary: This study investigated the effects of fine particulate matter organic extract (Po) exposure on pulmonary inflammation and assessed the role of sex in this process. The results showed that Po exposure induced lung inflammation, increased cell numbers in bronchoalveolar lavage fluid (BALF), and upregulated inflammatory cytokines in BALF. The analysis revealed an interaction between sex and Po exposure in the inflammatory cell numbers and levels of TNF-alpha, IL-5, and GRO/KC. Female mice were more susceptible to inflammation induced by Po exposure. The involvement of ER beta in these processes was also observed.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, General & Internal
Antonio Martinez-Ortega, Alvaro Flores-Martinez, Eva Venegas-Moreno, Elena Dios, Diego Del Can, Eloy Rivas, Ariel Kaen, Eugenio Cardenas Ruiz-Valdepenas, Elena Fajardo, Florinda Roldan, Natividad Gonzalez-Rivera, Rosario Oliva, Jose Ignacio Fernandez-Pena, Alfonso Soto-Moreno, David A. Cano
Summary: This study systematically analyzed the expression of estrogen receptor alpha (ER alpha) and progesterone receptor (PR) in craniopharyngiomas (CPs) and explored their potential association with tumor aggressiveness features. The results showed that a substantial proportion of CPs displayed PR expression, but most CPs expressed low levels of ER alpha. No major association between PR and ER alpha expression and clinical aggressiveness features was observed in CPs. Additionally, beta-catenin accumulation was not related to tumor recurrence in this series.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Peibin Lin, Xiaojing Zhang, Baoyi Zhu, Jun Gao, Dazhong Yin, Jianwen Zeng, Zhanfang Kang
Summary: Naringenin specifically activates ER beta to improve insulin secretion, protects beta cell function, and reverses glucose dysregulation in diabetic rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Naoko Honma, Tomio Arai, Yoko Matsuda, Yosuke Fukunaga, Yuri Akishima-Fukasawa, Noriko Yamamoto, Hiroshi Kawachi, Yuichi Ishikawa, Kengo Takeuchi, Tetuo Mikami
Summary: This study confirms differences in the pathobiological role of estrogens in postmenopausal colon cancer based on patient age and tumor background. Estrogens were found to promote certain types of tumors while suppressing others, which may partly explain the controversy surrounding the association between estrogens and CRC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Dandan Song, Huan He, Rajitha Indukuri, Zhiqiang Huang, Lina Stepanauskaite, Indranil Sinha, Lars-Arne Haldosen, Chunyan Zhao, Cecilia Williams
Summary: This study investigates the differences between estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) in regulating cell proliferation and migration. The results show that ERα and ERβ have opposite effects on cell proliferation and different impacts on migration. Furthermore, they regulate distinct sets of target genes, providing valuable insights into the mechanisms of these two different ER isoforms.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Isabela Ribeiro Madalena, Guido Artemio Maranon-Vasquez, Marjorie Ayumi Omori, Emerson Tavares de Sousa, Heitor Albergoni da Silveira, Jorge Esquiche Leon, Flares Baratto-Filho, Sandra Yasuyo Fukada Alves, Maria Bernadete Sasso Stuani, Paulo Nelson-Filho, Christian Kirschneck, Erika Calvano Kuechler
Summary: The aim of this study was to assess the effects of estrogen deficiency on tooth eruption rate (TER) and gene expression of estrogen receptor alpha and beta (ER alpha and ER beta) in a rat model. The results showed that estrogen deficiency decreased TER in teeth under impeded condition and increased gene expression of ER beta in the odontogenic region of teeth with continuous formation.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Endocrinology & Metabolism
Yi Lu, Qian Jiang, Lihua Yu, Zhan-Ying Lu, Shuang-Ping Meng, Dingfeng Su, Geoffrey Burnstock, Bei Ma
Article
Biochemistry & Molecular Biology
Qian Jiang, Wenxin Li, Xu Zhu, Lihua Yu, Zhanying Lu, Yuchen Liu, Bei Ma, Liming Cheng
Summary: ERP agonists can inhibit inflammation in IBD animal models by down-regulating P2X7R expression and inhibiting IL-1 beta release from macrophages through the JAK2/STAT3 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Behavioral Sciences
Qian Jiang, Chao-Ran Li, Wen-Feng Zeng, Hui-Jing Xu, Jia-Mei Li, Ting Zhang, Guang-Hui Deng, Yun-Xia Wang
Summary: By regulating the expression of Cx36, inhibiting HMGB1 signaling in hippocampal neurons can alleviate depressive-like behaviors induced by chronic unpredictable mild stress (CUMS).
BRAIN AND BEHAVIOR
(2022)