Article
Clinical Neurology
Alexander C. Conley, Kimberly M. Albert, Brenna C. McDonald, Andrew J. Saykin, Julie A. Dumas, Paul A. Newhouse
Summary: Older women are at higher risk of developing Alzheimer's disease compared to men. This study investigated the effect of estrogen treatment on cognitive performance in postmenopausal women and its relationship to self-reported cognitive complaints. The findings suggest that estrogen treatment did not improve cognitive performance in women with subjective cognitive complaints and may worsen attention tasks. Moreover, cognitive complaints following menopause may be associated with a decline in cholinergic function.
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
(2022)
Article
Neurosciences
Britta Hahn, Alexander N. Harvey, Marta Concheiro-Guisan, Marilyn A. Huestis, Thomas J. Ross, Elliot A. Stein
Summary: This study found that nAChR antagonist can weaken task-induced deactivation of the DMN, indicating that the constant activation tone of nAChR typically helps regulate DMN activity in healthy individuals. This implies that low nAChR tone may play a causal role in DMN dysregulation seen in conditions such as mild cognitive impairment or Alzheimer's disease.
PSYCHOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Thi Xuan Mai Tran, Yoosoo Chang, Soyeoun Kim, Huiyeon Song, Seungho Ryu, Boyoung Park
Summary: This study investigated the association between family history of breast cancer (FHBC) and mammographic breast density and density changes among premenopausal women. The results showed that women with FHBC had higher breast density, and the association varied depending on the affected relatives. These findings emphasize the importance of tailored breast cancer risk assessment for women with FHBC.
Article
Nutrition & Dietetics
Dae Young Yoo, Soonwoong Jung, Jae Soon Kang, Ji Hyeong Baek, Ki Hun Park, Dong Hoon Lee, Sang Soo Kang, Hyun Joon Kim
Summary: This study investigated the effects of isoflavone-enriched soybean leaves on cognitive impairment induced by ovariectomy in female mice.
Article
Biochemistry & Molecular Biology
Tiantian Zhao, Chen Zhang, Saiyi Zhong, Qirong Chen, Shuo Liu, Wenjuan Jiao, Weifeng Liu, Lihua Huang, Yehui Zhang, Yousheng Zhang
Summary: Anchovy protein hydrolysates (APH) and catechin (CA) have been shown to improve memory. This study investigated the effects of APH-CA conjugates on memory enhancement, gut microbiota, fecal metabolites, and neurotransmitters in mice. The results showed that APH-CA regulated various biomarkers and had better alleviating effects than APH and CA alone. The study also revealed possible connections between gut microbiota, fecal metabolites, and brain neurotransmitters. These findings suggest that the regulation of the microbiota-metabolites-brain-neurotransmitters axis may be one of the mechanisms for the cognitive enhancement effects of APH-CA, and the synergic effects of APH and CA were partially confirmed.
Article
Multidisciplinary Sciences
Gergely Somogyi, David Hlatky, Tamas Spisak, Zsofia Spisak, Gabriella Nyitrai, Andras Czurko
Summary: This study investigated the effects of scopolamine on brain activity using functional MRI in rats under different drug administration and anesthesia conditions. The results suggest that scopolamine may affect brain activation through central pathways, and its peripheral vascular actions depend on the type of anesthesia or dose.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Carmela Belardo, Serena Boccella, Michela Perrone, Antimo Fusco, Andrea Maria Morace, Federica Ricciardi, Roozbe Bonsale, Ines ELBini-Dhouib, Francesca Guida, Livio Luongo, Giacinto Bagetta, Damiana Scuteri, Sabatino Maione
Summary: This study examines the effects of PEA-OXA on scopolamine-induced deficits in working memory, discriminative memory, anxiety, and motor activity. It is found that PEA-OXA can prevent or restore scopolamine-induced cognitive deficits, specifically in discriminative and spatial memory. However, it does not affect the altered motor activity or anxiety-like behavior induced by scopolamine. The study confirms the neuroprotective and pro-cognitive effects of PEA-OXA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Ryohei Tanaka-Kanegae, Hiroyuki Kimura, Koichiro Hamada
Summary: Enzyme-modified lecithin containing lysophosphatidylcholine (LPC) is considered safe but has been less studied as a functional ingredient compared to other choline-containing compounds like glycerophosphocholine (GPC). Limited reports on LPC as a cholinergic precursor and its kinetics only involve docosahexaenoic acid-bound LPC. This study investigated these processes in SCO-treated rats through three experiments.
Article
Nutrition & Dietetics
Pallavi Gurung, Rajeev Shrestha, Junmo Lim, Til Bahadur Thapa Magar, Han-Hyuk Kim, Yong-Wan Kim
Summary: The therapeutic and preventive effects of Euonymus alatus twig extract were investigated in a mouse model of cognitive deficit and B35 cells. The extract significantly improved the passive avoidance test in mice, restored the cholinergic systems and the BDNF/ERK/CREB pathway, and inhibited acetylcholine esterase activity in B35 cells.
Review
Oncology
Fatima Jebahi, Saryu Sharma, Jamie E. Bloss, Heather H. Wright
Summary: Breast cancer treatments, such as tamoxifen, can have adverse effects on cognitive and language functions in women. Specifically, memory and speed domains are negatively impacted by tamoxifen, with changes also noticed in executive functions and verbal abilities. Further research is needed to explore the effects of tamoxifen on different language domains.
Article
Geriatrics & Gerontology
Yamnia I. Cortes, Jianwen Cai, Martha Daviglus, Linda C. Gallo, Melissa Lamar, Carmen R. Isasi, Krista M. Perreira
Summary: Among postmenopausal Hispanic/Latinas, a longer reproductive period is associated with more favorable cognitive measures of verbal learning and processing speed. These findings support the hypothesis that greater lifetime exposure to estrogens may be associated with higher cognitive performance.
Article
Biochemistry & Molecular Biology
H. Sudeep, K. Venkatakrishna, Amritharaj, K. Gouthamchandra, B. Reethi, P. Naveen, H. B. Lingaraju, K. Shyamprasad
Summary: The study prepared an extract from black pepper seeds containing 30% BCP using supercritical fluid extraction, and demonstrated the beneficial effects of Viphyllin on cognitive functions in Scopolamine-induced dementia model mice. Viphyllin dose-dependently improved recognition and spatial memory, protected against oxidative damage in the brain, and exerted neuroprotective effects by modulating various signaling pathways including BDNF and MAPK. It also exhibited anti-inflammatory properties by downregulating inflammatory markers in the brain.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Psychology, Multidisciplinary
Sampurna Kundu, Sanghmitra Sheel Acharya
Summary: This study aims to explore the effect of premature and early menopause on cognitive health and psychosocial well-being. The findings showed that premature menopause is associated with decline in cognitive function, increased insomnia and depression symptoms, which are moderated by smoking habits. Therefore, it is important to raise awareness about the negative effects of smoking and conduct further research on the relationship between early menopause and psychosocial well-being.
Article
Clinical Neurology
Sygrid van der Zee, Martijn L. T. M. Muller, Prabesh Kanel, Teus van Laar, Nicolaas I. Bohnen
Summary: This study investigated the relationship between cognitive functioning and regional cholinergic innervation in patients with PD, utilizing [F-18]Fluoroethoxybenzovesamicol positron emission tomography imaging. The results showed partial overlapping topography across cognitive domains, with most robust correlations in the domains of memory, attention, and executive functioning. The findings confirm and expand on previous observations of cholinergic system involvement in cognitive functioning in PD, reflecting a combination of disease-specific and aging effects.
MOVEMENT DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Donghui Zhu, Axel Montagne, Zhen Zhao
Summary: AD is a neurodegenerative disease, with studies showing gender differences in risk and progression. The higher risk and progression of AD in women are largely attributed to distinct biological mechanisms, such as deviations in brain structure and biomarkers, psychosocial stress responses, genetic background, and more.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)