Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries

The Interplay between Mutasynthesis and Semisynthesis: Generation and Evaluation of an Ansamitocin Library

(2011) Simone Eichner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Assessing Oxazole Bioisosteres as Mutasynthons on the Rhizoxin Assembly Line

(2011) Björn Kusebauch et al.   CHEMBIOCHEM

Ten key issues in modern flow chemistry

(2011) Jens Wegner et al.   CHEMICAL COMMUNICATIONS

Combined Muta- and Semisynthesis: A Powerful Synthetic Hybrid Approach to Access Target Specific Antitumor Agents Based on Ansamitocin P3

(2011) Florian Taft et al.   CHEMISTRY-A EUROPEAN JOURNAL

Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

(2010) J. R. Junutula et al.   CLINICAL CANCER RESEARCH

Frontiers and Opportunities in Chemoenzymatic Synthesis

(2010) Jonathan D. Mortison et al.   JOURNAL OF ORGANIC CHEMISTRY

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms

(2010) Kento Koketsu et al.   Nature Chemical Biology

Biocatalytic asymmetric formation of tetrahydro-β-carbolines

(2010) Peter Bernhardt et al.   TETRAHEDRON LETTERS

New, Highly Active Nonbenzoquinone Geldanamycin Derivatives by Using Mutasynthesis

(2009) Simone Eichner et al.   CHEMBIOCHEM

Aza-Tryptamine Substrates in Monoterpene Indole Alkaloid Biosynthesis

(2009) Hyang-Yeol Lee et al.   CHEMISTRY & BIOLOGY

Opportunities for enzyme engineering in natural product biosynthesis

(2009) Peter Bernhardt et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Bypassing stereoselectivity in the early steps of alkaloid biosynthesis

(2009) Peter Bernhardt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and biochemical evaluation of des-vinyl secologanin aglycones with alternate stereochemistry

(2009) Peter Bernhardt et al.   TETRAHEDRON LETTERS

Mutasynthesis of Fluorosalinosporamide, a Potent and Reversible Inhibitor of the Proteasome

(2008) Alessandra S. Eustáquio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Active Ansamitocin Derivatives: Mutasynthesis Using an AHBA-Blocked Mutant

(2008) Florian Taft et al.   CHEMBIOCHEM

The chemistry and biology of the maytansinoid antitumor agents

(2008) Andreas Kirschning et al.   COMPTES RENDUS CHIMIE

Analysis of the Cryptophycin P450 Epoxidase Reveals Substrate Tolerance and Cooperativity

(2008) Yousong Ding et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substrate specificity and diastereoselectivity of strictosidine glucosidase, a key enzyme in monoterpene indole alkaloid biosynthesis

(2007) Nancy Yerkes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS