Genetic manipulation of non-ribosomal peptide synthetases to generate novel bioactive peptide products

Biosynthesis of Novel Pyoverdines by Domain Substitution in a Nonribosomal Peptide Synthetase of Pseudomonas aeruginosa

(2014) Mark J. Calcott et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange

(2014) Ralf Beer et al.   Molecular BioSystems

Prediction of Monomer Isomery in Florine: A Workflow Dedicated to Nonribosomal Peptide Discovery

(2014) Thibault Caradec et al.   PLoS One

Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

(2013) Kieron M. G. O'Connell et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering the Substrate Specificity of the DhbE Adenylation Domain by Yeast Cell Surface Display

(2013) Keya Zhang et al.   CHEMISTRY & BIOLOGY

Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries

(2012) Andreas Kirschning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity

(2012) Jenny Thirlway et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-directed modification of the adenylation domain of the fusaricidin nonribosomal peptide synthetase for enhanced production of fusaricidin analogs

(2012) Jae Woo Han et al.   BIOTECHNOLOGY LETTERS

Structure guided approaches toward exploiting and manipulating nonribosomal peptide and polyketide biosynthetic pathways

(2012) Heather L Condurso et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Improving known classes of antibiotics: an optimistic approach for the future

(2012) Karen Bush   CURRENT OPINION IN PHARMACOLOGY

A functional screen for recovery of 4′-phosphopantetheinyl transferase and associated natural product biosynthesis genes from metagenome libraries

(2012) J. G. Owen et al.   ENVIRONMENTAL MICROBIOLOGY

Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology

(2012) Gene H. Hur et al.   NATURAL PRODUCT REPORTS

Directed Evolution of a Gatekeeper Domain in Nonribosomal Peptide Synthesis

(2011) Benoit Villiers et al.   CHEMISTRY & BIOLOGY

Directed Evolution of the Nonribosomal Peptide Synthetase AdmK Generates New Andrimid Derivatives In Vivo

(2011) Bradley S. Evans et al.   CHEMISTRY & BIOLOGY

Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity

(2011) Marc Röttig et al.   NUCLEIC ACIDS RESEARCH

Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties

(2010) K. T. Nguyen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Nonribosomal peptide synthetases: structures and dynamics

(2010) Matthias Strieker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Diversity of Monomers in Nonribosomal Peptides: towards the Prediction of Origin and Biological Activity

(2010) S. Caboche et al.   JOURNAL OF BACTERIOLOGY

Expression and purification of an adenylation domain from a eukaryotic nonribosomal peptide synthetase: Using structural genomics tools for a challenging target

(2010) T. Verne Lee et al.   PROTEIN EXPRESSION AND PURIFICATION

Working outside the protein-synthesis rules: insights into non-ribosomal peptide synthesis

(2009) Mohamed A. Marahiel   JOURNAL OF PEPTIDE SCIENCE

Computational structure-based redesign of enzyme activity

(2009) C.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-ribosomal peptide synthetase module fusions to produce derivatives of daptomycin in Streptomyces roseosporus

(2008) S. Doekel et al.   MICROBIOLOGY-SGM

Nonribosomal Peptide Synthetases Involved in the Production of Medically Relevant Natural Products

(2008) Elizabeth A. Felnagle et al.   MOLECULAR PHARMACEUTICS

The evolution of gene collectives: How natural selection drives chemical innovation

(2008) M. A. Fischbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE