RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability

A module for Rac temporal signal integration revealed with optogenetics

(2017) Brian R. Graziano et al.   JOURNAL OF CELL BIOLOGY

Rho GTPase signaling complexes in cell migration and invasion

(2017) Campbell D. Lawson et al.   JOURNAL OF CELL BIOLOGY

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

(2017) Robert J. Eddy et al.   TRENDS IN CELL BIOLOGY

Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer

(2016) Laralynne Przybyla et al.   Annual Review of Cell and Developmental Biology

The involvement of mutant Rac1 in the formation of invadopodia in cultured melanoma cells

(2016) Or-Yam Revach et al.   EXPERIMENTAL CELL RESEARCH

Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins

(2016) Ehsan Amin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulating Rho GTPases and their regulators

(2016) Richard G. Hodge et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function

(2016) W. Ba et al.   Cell Reports

Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits

(2016) Valentina Zamboni et al.   Scientific Reports

Specification of Architecture and Function of Actin Structures by Actin Nucleation Factors

(2015) Colleen T. Skau et al.   Annual Review of Biophysics

A Fluorescent Live Imaging Screening Assay Based on Translocation Criteria Identifies Novel Cytoplasmic Proteins Implicated in G Protein-coupled Receptor Signaling Pathways

(2015) Sandra Lecat et al.   MOLECULAR & CELLULAR PROTEOMICS

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins

(2015) Daniel Schlam et al.   Nature Communications

Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathways

(2014) Anya Rudnicki et al.   BMC GENOMICS

Insights into the biological functions of Dock family guanine nucleotide exchange factors

(2014) M. Laurin et al.   GENES & DEVELOPMENT

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

Functional Cross-talk between Ras and Rho Pathways

(2014) Mamta Jaiswal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Decision making inxia2

(2013) Graeme Winter et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

ArhGAP15, a Rac-specific GTPase-activating Protein, Plays a Dual Role in Inhibiting Small GTPase Signaling

(2013) Maria Radu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

(2013) D R Cook et al.   ONCOGENE

miR-199a-5p Regulates Urothelial Permeability and May Play a Role in Bladder Pain Syndrome

(2012) Katia Monastyrskaya et al.   AMERICAN JOURNAL OF PATHOLOGY

G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly

(2012) M. Wiezlak et al.   JOURNAL OF CELL SCIENCE

Actin-regulated feedback loop based on Phactr4, PP1 and cofilin maintains the actin monomer pool

(2012) G. Huet et al.   JOURNAL OF CELL SCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Structures of the Phactr1 RPEL Domain and RPEL Motif Complexes with G-Actin Reveal the Molecular Basis for Actin Binding Cooperativity

(2012) Stephane Mouilleron et al.   STRUCTURE

Actin Structure and Function

(2011) Roberto Dominguez et al.   Annual Review of Biophysics

Sensing actin dynamics: Structural basis for G-actin-sensitive nuclear import of MAL

(2011) Hidemi Hirano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cdc42 in oncogenic transformation, invasion, and tumorigenesis

(2011) Kristy Stengel et al.   CELLULAR SIGNALLING

Actin as target for modification by bacterial protein toxins

(2011) Klaus Aktories et al.   FEBS Journal

Development of an optimized backbone of FRET biosensors for kinases and GTPases

(2011) Naoki Komatsu et al.   MOLECULAR BIOLOGY OF THE CELL

Structure of a Pentavalent G-Actin*MRTF-A Complex Reveals How G-Actin Controls Nucleocytoplasmic Shuttling of a Transcriptional Coactivator

(2011) S. Mouilleron et al.   Science Signaling

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural Basis for Actin Assembly, Activation of ATP Hydrolysis, and Delayed Phosphate Release

(2010) Kenji Murakami et al.   CELL

An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A

(2010) Rafał Pawłowski et al.   EMBO JOURNAL

Direct visualization of secondary structures of F-actin by electron cryomicroscopy

(2010) Takashi Fujii et al.   NATURE

Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

(2009) Souhila Medjkane et al.   NATURE CELL BIOLOGY

MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis

(2008) Ling Kong et al.   CELL RESEARCH

Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL

(2008) Stephane Mouilleron et al.   EMBO JOURNAL

PX-RICS mediates ER-to-Golgi transport of the N-cadherin/ -catenin complex

(2008) T. Nakamura et al.   GENES & DEVELOPMENT

Met-driven invasive growth involves transcriptional regulation of Arhgap12

(2008) A Gentile et al.   ONCOGENE

Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning

(2007) Miho Matsuda et al.   EXPERIMENTAL CELL RESEARCH