Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants

RNA interference in vitro and in vivo using DsiRNA targeting the nucleocapsid N mRNA of human metapneumovirus

(2012) Magali Darniot et al.   ANTIVIRAL RESEARCH

Quantitative functions of Argonaute proteins in mammalian development

(2012) D. Wang et al.   GENES & DEVELOPMENT

Precursor MicroRNA-Programmed Silencing Complex Assembly Pathways in Mammals

(2012) Xuhang Liu et al.   MOLECULAR CELL

Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing

(2012) Anne Dallas et al.   NUCLEIC ACIDS RESEARCH

Functional parameters of Dicer-independent microRNA biogenesis

(2012) J.-S. Yang et al.   RNA

Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo

(2012) D. J. Foster et al.   RNA

Widespread RNA 3'-end oligouridylation in mammals

(2012) Y. S. Choi et al.   RNA

Deep Sequencing Analyses of DsiRNAs Reveal the Influence of 3′ Terminal Overhangs on Dicing Polarity, Strand Selectivity, and RNA Editing of siRNAs

(2012) Jiehua Zhou et al.   Molecular Therapy-Nucleic Acids

Species specific inhibition of viral replication using dicer substrate siRNAs (DsiRNAs) targeting the viral nucleoprotein of the fish pathogenic rhabdovirus viral hemorrhagic septicemia virus (VHSV)

(2011) Harry Bohle et al.   ANTIVIRAL RESEARCH

Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells

(2011) Alessia Baccarini et al.   CURRENT BIOLOGY

Protection against TNFα-dependent liver toxicity by intraperitoneal liposome delivered DsiRNA targeting TNFα in vivo

(2011) Patric Lundberg et al.   JOURNAL OF CONTROLLED RELEASE

siRNA Repositioning for Guide Strand Selection by Human Dicer Complexes

(2011) Cameron L. Noland et al.   MOLECULAR CELL

Current prospects for RNA interference-based therapies

(2011) Beverly L. Davidson et al.   NATURE REVIEWS GENETICS

Structure of C3PO and mechanism of human RISC activation

(2011) Xuecheng Ye et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes

(2011) S. Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dicer is dispensable for asymmetric RISC loading in mammals

(2011) J. G. Betancur et al.   RNA

Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing

(2011) J. A. Broderick et al.   RNA

The potential functions of primary microRNAs in target recognition and repression

(2010) Robin Deis Trujillo et al.   EMBO JOURNAL

Mammalian microRNAs: experimental evaluation of novel and previously annotated genes

(2010) H. R. Chiang et al.   GENES & DEVELOPMENT

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

(2010) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

A role for human Dicer in pre-RISC loading of siRNAs

(2010) Kumi Sakurai et al.   NUCLEIC ACIDS RESEARCH

Target RNA-Directed Trimming and Tailing of Small Silencing RNAs

(2010) S. L. Ameres et al.   SCIENCE

Binding and Cleavage Specificities of Human Argonaute2

(2009) Walt F. Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Viral and Human RNAs Smaller than Canonical MicroRNAs

(2009) Z. Li et al.   JOURNAL OF VIROLOGY

Asymmetric Shorter-duplex siRNA Structures Trigger Efficient Gene Silencing With Reduced Nonspecific Effects

(2009) Chan Il Chang et al.   MOLECULAR THERAPY

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

ATP-dependent human RISC assembly pathways

(2009) Mayuko Yoda et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into RNA processing by the human RISC-loading complex

(2009) Hong-Wei Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expanded RNA-binding activities of mammalian Argonaute 2

(2009) Grace S. Tan et al.   NUCLEIC ACIDS RESEARCH

TRBP Control of PACT-Induced Phosphorylation of Protein Kinase R Is Reversed by Stress

(2008) A. Daher et al.   MOLECULAR AND CELLULAR BIOLOGY

Central Delivery of Dicer-substrate siRNA: A Direct Application for Pain Research

(2008) Louis Doré-Savard et al.   MOLECULAR THERAPY

Chitosan/siRNA Nanoparticle–mediated TNF-α Knockdown in Peritoneal Macrophages for Anti-inflammatory Treatment in a Murine Arthritis Model

(2008) Kenneth A Howard et al.   MOLECULAR THERAPY

Asymmetric RNA duplexes mediate RNA interference in mammalian cells

(2008) Xiangao Sun et al.   NATURE BIOTECHNOLOGY

Chemical Modification Patterns Compatible with High Potency Dicer-Substrate Small Interfering RNAs

(2008) Michael A. Collingwood et al.   OLIGONUCLEOTIDES

In vitro reconstitution of the human RISC-loading complex

(2008) I. J. MacRae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent RNAi by short RNA triggers

(2008) C.-y. Chu et al.   RNA

Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs

(2008) M. Landthaler et al.   RNA

Chemically modified symmetric and asymmetric duplex RNAs: An enhanced stability to nuclease degradation and gene silencing effect

(2007) Takanori Kubo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS