Erianin Inhibits Proliferation and Induces Apoptosis of HaCaT Cells via ROS-Mediated JNK/c-Jun and AKT/mTOR Signaling Pathways

Cold atmospheric plasma ameliorates imiquimod-induced psoriasiform dermatitis in mice by mediating antiproliferative effects

(2019) Lu Gan et al.   FREE RADICAL RESEARCH

Apoptotic or Antiproliferative Activity of Natural Products against Keratinocytes for the Treatment of Psoriasis

(2019) Tse-Hung Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits bladder cancer cell growth via the mitochondrial apoptosis and JNK pathways

(2019) Qiyu Zhu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Topical Sunitinib ointment alleviates Psoriasis-like inflammation by inhibiting the proliferation and apoptosis of keratinocytes

(2018) Ye-Hong Kuang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metformin Promotes HaCaT Cell Apoptosis through Generation of Reactive Oxygen Species via Raf-1-ERK1/2-Nrf2 Inactivation

(2018) Xiaoyan Wang et al.   INFLAMMATION

Epidermal barrier and oxidative stress parameters improve during in 311 nm narrow band UVB phototherapy of plaque type psoriasis

(2018) Razvigor Darlenski et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation

(2018) Ying-Qiang Shen et al.   JOURNAL OF PINEAL RESEARCH

A unified mitochondria mechanistic target of rapamycin acyl-coenzyme A dehydrogenase 10 signal relay modulation for metformin growth inhibition in human immortalized keratinocytes cells

(2018) Jiawen Wu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

IL-22 downregulates Cx43 expression and decreases gap junctional intercellular communication by activating the JNK pathway in psoriasis

(2018) Jingyao Liang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Epidermal mTORC1 Signaling Contributes to the Pathogenesis of Psoriasis and Could Serve as a Therapeutic Target

(2018) Claudia Buerger   Frontiers in Immunology

Psoriasis pathogenesis and the development of novel targeted immune therapies

(2017) Jason E. Hawkes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation

(2017) Alexey V. Zamaraev et al.   TRENDS IN CELL BIOLOGY

Mitochondrial Cardiomyopathy Caused by Elevated Reactive Oxygen Species and Impaired Cardiomyocyte Proliferation

(2017) Donghui Zhang et al.   CIRCULATION RESEARCH

Reactive Oxygen Species Regulate Innate But Not Adaptive Inflammation in ZAP70-Mutated SKG Arthritic Mice

(2016) Simon Guerard et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2

(2016) Ji Liang et al.   CELL RESEARCH

Oxidative stress in psoriasis and potential therapeutic use of antioxidants

(2016) Xiran Lin et al.   FREE RADICAL RESEARCH

Erianin induces G2/M-phase arrest, apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo

(2016) H Wang et al.   Cell Death & Disease

Erianin inhibits high glucose-induced retinal angiogenesis via blocking ERK1/2-regulated HIF-1α-VEGF/VEGFR2 signaling pathway

(2016) Zengyang Yu et al.   Scientific Reports

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation

(2015) Rikard Holmdahl et al.   IMMUNOLOGICAL REVIEWS

Psoriasis

(2015) Wolf-Henning Boehncke et al.   LANCET

Phosphoinositide-3 Kinase/Protein Kinase-B/Mammalian Target of Rapamycin Pathway in Psoriasis Pathogenesis. A Potential Therapeutic Target?

(2014) T Huang et al.   ACTA DERMATO-VENEREOLOGICA

Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes

(2014) Zorica Janjetovic et al.   JOURNAL OF PINEAL RESEARCH

Methotrexate Induces Apoptosis in Nasal Polyps via Caspase Cascades and Both Mitochondria-Mediated and p38 Mitogen-Activated Protein Kinases/Jun N-terminal Kinase Pathways

(2013) Hong Wook Cho et al.   American Journal of Rhinology & Allergy

1,25-dihydroxyvitamin D3-3-bromoacetate, a novel vitamin D analog induces immunosuppression through PI3K/Akt/mTOR signaling cascade

(2013) Ananya Datta-Mitra et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Targeting the Redox Balance in Inflammatory Skin Conditions

(2013) Frank Wagener et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

1α,25-Dihydroxyvitamin-D3-3-Bromoacetate Regulates AKT/mTOR Signaling Cascades: A Therapeutic Agent for Psoriasis

(2013) Ananya Datta Mitra et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

An investigation of the effects of dithranol-induced apoptosis in a human keratinocyte cell line

(2013) Suja E. George et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

α-santalol inhibits the angiogenesis and growth of human prostate tumor growth by targeting vascular endothelial growth factor receptor 2-mediated AKT/mTOR/P70S6K signaling pathway

(2013) Sarita Saraswati et al.   Molecular Cancer

Quercetin enhancement of arsenic-induced apoptosis via stimulating ROS-dependent p53 protein ubiquitination in human HaCaT keratinocytes

(2012) Shing-Chuan Shen et al.   EXPERIMENTAL DERMATOLOGY

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Impact of reactive oxygen species on keratinocyte signaling pathways

(2012) Toshinori Bito et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

TNF-like weak inducer of apoptosis (TWEAK) and TNF-α cooperate in the induction of keratinocyte apoptosis

(2011) Maya Zimmermann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oxidative stress in the pathogenesis of psoriasis

(2009) Qiang Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of the JNK signal transduction pathway in inflammatory bowel disease

(2008) Praveen K Roy et al.   WORLD JOURNAL OF GASTROENTEROLOGY