Article
Chemistry, Medicinal
Yuqian Wang, Dan Han, Yingjian Huang, Yilin Dai, Yan Wang, Meng Liu, Ning Wang, Tingyi Yin, Wenqian Du, Ke He, Yan Zheng
Summary: Punicalagin-enriched pomegranate extract can alleviate inflammation and lesions in psoriasis, inhibit cell proliferation and cytokine expression, and improve the quality of life for patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Onofrio Laselva, Caterina Allegretta, Sante Di Gioia, Carlo Avolio, Massimo Conese
Summary: DMF demonstrates anti-inflammatory and antioxidant effects in CF treatment, reducing inflammatory responses, restoring CFTR function, and potentially serving as a novel drug to ameliorate lung inflammation in CF patients and enhance drug efficacy.
Article
Oncology
Hongxia Li, Yaping Wang, Rina Su, Yuchen Jia, Xiong Lai, Huimin Su, Yaochun Fan, Yuewu Wang, Wanjin Xing, Jianzhong Qin
Summary: Combination treatment of dimethyl fumarate (DMF) and vemurafenib (Vem) exhibits enhanced antitumor efficacy in melanoma by inhibiting multiple cell signaling pathways, leading to inhibition of cell proliferation and induction of cell death.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Liam E. E. Carman, Michael L. L. Samulevich, Brian J. J. Aneskievich
Summary: The overactivity of keratinocyte cytoplasmic signaling is implicated in cutaneous inflammatory and immune pathologies. Certain proteins and protein complexes can repress this signaling to limit inflammation, distinguishing them from activators and amplifiers of inflammation. Defects or deficiencies in these proteins have been linked to maintaining non-activated or post-inflamed states of keratinocytes, helping to resolve acute inflammatory responses and prevent chronic inflammatory disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Anja Schmitt, Wendan Xu, Philip Bucher, Melanie Grimm, Martina Konantz, Heike Horn, Myroslav Zapukhlyak, Philipp Berning, Marc Braendle, Mohamed-Ali Jarboui, Caroline Sch Onfeld, Karsten Boldt, Andreas Rosenwald, German Ott, Michael Grau, Pavel Klener, Petra Vockova, Claudia Lengerke, Georg Lenz, Klaus Schulze-Osthoff, Stephan Hailfinger
Summary: The study demonstrates the broad antitumor effect of dimethyl fumarate (DMF) on both subtypes of DLBCL by inducing ferroptosis, especially in GCB DLBCL. In ABC DLBCL cells, DMF treatment efficiently inhibits the activity of the IKK complex and Janus kinases. Additionally, the combination of BCL-2-specific BH3 mimetic ABT-199 and an inhibitor of ferroptosis suppressor protein 1 synergize with DMF in inducing cell death in DLBCL.
Article
Biology
M. Carmen Ocana, Manuel Bernal, Chendong Yang, Carlos Caro, Alejandro Dominguez, Hieu S. Vu, Casimiro Cardenas, Maria Luisa Garcia-Martin, Ralph J. Deberardinis, Ana R. Quesada, Beatriz Martinez-Poveda, Miguel Angel Medina
Summary: This study reveals that dimethyl fumarate affects the energetic metabolism of endothelial cells, promoting glycolysis and reducing cell respiration. This new finding could offer insights into the mechanism of action of dimethyl fumarate.
COMMUNICATIONS BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Young-Sun Lee, Deepak Prasad Gupta, Sung Hee Park, Hyun-Jeong Yang, Gyun Jee Song
Summary: The study found that DMF can inhibit nitric oxide and proinflammatory cytokine production in microglia, induce microglial switching to the M2 state, increase the expression levels of autophagy markers such as LC3 and ATG7, and promote the formation of autophagosomes. These results suggest that DMF induces autophagy in microglia and its anti-inflammatory effects are partially mediated through an autophagy-dependent pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Sorour Ashari, Navid Naghsh, Yasaman Salari, Nasrin Ghassemi Barghi, Abouzar Bagheri
Summary: This study found that DMF can partially alleviate DEHP-induced nephrotoxicity through modulation of oxidative stress, mitochondrial function, and inflammation.
Article
Oncology
Ziqian Xu, Wan Tang, Qiaoling Xie, Xinyu Cao, Mengni Zhang, Xiaoxun Zhang, Jin Chai
Summary: Dimethyl fumarate (DMF) has been found to have a protective effect on cholestatic liver disease by regulating antioxidant capacity, reducing liver inflammation, and regulating the levels of bile acid transporters. These findings provide new strategies for the treatment of cholestatic liver disorders.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Anatomy & Morphology
Yanhong Mi, Xiaoxiao Xie, Zhongkun Bao, Xiaoyu Xiong, Xinhong Wang, Hongxi Zhang
Summary: The study aimed to investigate the protective effect of dimethyl fumarate (DMF) on necrotizing enterocolitis (NEC) and its mechanism. Results showed that DMF attenuated NEC-induced weight loss and abdominal distension diarrhea, alleviated intestinal pathological injuries, and inhibited intestinal cell apoptosis. These effects were related to the inhibition of the TLR signaling pathway and alleviation of the inflammatory response.
Article
Dermatology
J. Sulaimani, D. Cluxton, J. Clowry, A. Petrasca, O. E. Molloy, B. Moran, C. M. Sweeney, A. Malara, N. McNicholas, C. McGuigan, B. Kirby, J. M. Fletcher
Summary: DMF has been shown to increase the frequency of Treg cells and decrease Th17 cells in patients with psoriasis. It also inhibits T cell activation and proliferation in response to stimulation, while enhancing the resistance of Treg cells to oxidative stress induced by DMF.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kosuke Kato, Ioannis Papageorgiou, Yoon-Joo Shin, Jennifer M. Kleinhenz, Sunny Palumbo, Seongmin Hahn, Joseph D. Irish, Skye P. Rounseville, Kenneth S. Knox, Louise Hecker
Summary: This study demonstrates that DMF treatment can inhibit pro-fibrotic phenotypes in IPF lung fibroblasts and reverse established pro-fibrotic phenotypes. Lung-targeted delivery of DMF restores Nrf2 expression levels, reduces lung oxidative stress, and promotes the resolution of age-dependent established fibrosis.
Article
Biochemistry & Molecular Biology
Rui Yang, Shibo Sun, Yining Guo, Yao Meng, Haowen Liu, Meiyun Shi, Shui Guan, Jianqiang Xu
Summary: Macrophages secrete pro-inflammatory cytokines in response to pathogens, but abnormal release of cytokines can lead to cytokine storms. This study found that DMF can inhibit TXNRD1 and alleviate inflammation through activating NRF2. Targeting TXNRD1 may be a potential mechanism for immunometabolites to regulate inflammation.
Article
Medicine, General & Internal
Sudhir K. Yadav, Naoko Ito, Devika Soin, Kouichi Ito, Suhayl Dhib-Jalbut
Summary: DMF reduces proliferation of T cells and production of pro-inflammatory factors, leading to decreased development and deposition of macrophages and astrocytes in the CNS, thereby reducing demyelination and axonal loss.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Pengwei Li, Mingxian Chang
Summary: Oxidative stress plays a significant role in inflammatory diseases, characterized by the overproduction of reactive oxygen species (ROS). Inflammatory signaling cascades are initiated through the recognition of DAMPs and PAMPs by PRRs, with different PRRs families affecting the production of ROS and/or oxidative stress. Studying the correlation between oxidative stress and PRRs-mediated signaling pathways is crucial for future therapeutic strategies in inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)