An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis

Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells

(2014) S. W. Hofbauer et al.   BLOOD

Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1

(2014) X. Su et al.   GENES & DEVELOPMENT

DNA Damage Induces the Accumulation of Tiam1 by Blocking β-TrCP-dependent Degradation

(2014) Guixin Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1

(2014) Julien Viaud et al.   Nature Communications

Flagellar regeneration requires cytoplasmic microtubule depolymerization and kinesin-13

(2013) L. Wang et al.   JOURNAL OF CELL SCIENCE

Combined Inhibition of HER1/EGFR and RAC1 Results in a Synergistic Antiproliferative Effect on Established and Primary Cultured Human Glioblastoma Cells

(2013) G. Karpel-Massler et al.   MOLECULAR CANCER THERAPEUTICS

RAC1: An Emerging Therapeutic Option for Targeting Cancer Angiogenesis and Metastasis

(2013) H. K. Bid et al.   MOLECULAR CANCER THERAPEUTICS

PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1

(2013) H. Ebi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

EGFR Inhibition in Glioma Cells Modulates Rho Signaling to Inhibit Cell Motility and Invasion and Cooperates with Temozolomide to Reduce Cell Growth

(2012) Guillem Ramis et al.   PLoS One

EGFR Mutations and Lung Cancer

(2011) Gilda da Cunha Santos et al.   Annual Review of Pathology-Mechanisms of Disease

Resistance to EGFR-Targeted Therapy: A Family Affair

(2011) Gregory Vlacich et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Rac signaling in breast cancer: A tale of GEFs and GAPs

(2011) Eva Wertheimer et al.   CELLULAR SIGNALLING

Involvement of 14-3-3 Proteins in the Second Epidermal Growth Factor-induced Wave of Rac1 Activation in the Process of Cell Migration

(2011) Hiroki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tiam1 is recruited to β1-integrin complexes by 14-3-3ζ where it mediates integrin-induced Rac1 activation and motility

(2011) Timothy E. O'Toole et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Feedback regulation of EGFR signalling: decision making by early and delayed loops

(2011) Roi Avraham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells

(2011) G Zhu et al.   ONCOGENE

Activation of ERBB2 Signaling Causes Resistance to the EGFR-Directed Therapeutic Antibody Cetuximab

(2011) K. Yonesaka et al.   Science Translational Medicine

Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer

(2010) Maria Soledad Sosa et al.   MOLECULAR CELL

A Modified Tandem Affinity Purification Technique Identifies That 14-3-3 Proteins Interact with Tiam1, an Interaction Which Controls Tiam1 Stability

(2009) Simon A. Woodcock et al.   JOURNAL OF PROTEOME RESEARCH

Endocytic Trafficking of Rac Is Required for the Spatial Restriction of Signaling in Cell Migration

(2008) Andrea Palamidessi et al.   CELL

Rho GTPases in cancer cell biology

(2008) Francisco M. Vega et al.   FEBS LETTERS

Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice

(2008) K. Strumane et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF

(2008) R. E. Itoh et al.   JOURNAL OF CELL SCIENCE

AKT Is Activated in an Ataxia-Telangiectasia and Rad3-Related-Dependent Manner in Response to Temozolomide and Confers Protection against Drug-Induced Cell Growth Inhibition

(2008) S. Caporali et al.   MOLECULAR PHARMACOLOGY

The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

(2008) Deborah K. Morrison   TRENDS IN CELL BIOLOGY

Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration

(2007) Rebecca S. Dise et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY