Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse

It’s all about tau

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Association Between Body Mass Index and Disease Severity in Chinese Spinocerebellar Ataxia Type 3 Patients

(2018) Jin-Shan Yang et al.   CEREBELLUM

Machado-Joseph disease / Spinocerebellar ataxia type 3:lessons from disease pathogenesis and clues into therapy

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Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model

(2018) Lodewijk J. A. Toonen et al.   Molecular Neurodegeneration

Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function

(2018) Line V. Kristensen et al.   NEUROCHEMISTRY INTERNATIONAL

Body composition in Spinocerebellar ataxia type 3 and 10 patients: Comparative study with control group

(2018) Christiane de M. B. Almeida Leite et al.   NUTRITIONAL NEUROSCIENCE

Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3

(2018) Anna Sergeevna Sowa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Vulnerability of frontal brain neurons for the toxicity of expanded ataxin-3

(2018) Jana Schmidt et al.   HUMAN MOLECULAR GENETICS

Physiological and pathophysiological characteristics of ataxin-3 isoforms

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Shared and distinct transcriptomic cell types across neocortical areas

(2018) Bosiljka Tasic et al.   NATURE

Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes

(2017) Biswarathan Ramani et al.   HUMAN MOLECULAR GENETICS

The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export

(2017) Jekaterina Vohhodina et al.   NUCLEIC ACIDS RESEARCH

WikiPathways: a multifaceted pathway database bridging metabolomics to other omics research

(2017) Denise N Slenter et al.   NUCLEIC ACIDS RESEARCH

Ataxin-3 promotes genome integrity by stabilizing Chk1

(2017) Yingfeng Tu et al.   NUCLEIC ACIDS RESEARCH

The Reactome Pathway Knowledgebase

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Neurofilaments and Neurofilament Proteins in Health and Disease

(2017) Aidong Yuan et al.   Cold Spring Harbor Perspectives in Biology

Parvalbumin-Expressing GABAergic Neurons in Primary Motor Cortex Signal Reaching

(2017) Luc Estebanez et al.   Cell Reports

The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models

(2017) Jung-Yu Hsu et al.   Frontiers in Molecular Neuroscience

Impaired Cerebellum to Primary Motor Cortex Associative Plasticity in Parkinson’s Disease and Spinocerebellar Ataxia Type 3

(2017) Ming-Kuei Lu et al.   Frontiers in Neurology

SIRT2 orchestrates the DNA damage response

(2016) Hui Zhang et al.   CELL CYCLE

Motor cortical dysfunction develops in spinocerebellar ataxia type 3

(2016) Michelle A. Farrar et al.   CLINICAL NEUROPHYSIOLOGY

PP2A as a master regulator of the cell cycle

(2016) Nathan Wlodarchak et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules

(2016) Meh Sameen Nawaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown

(2016) Mihaela Pertea et al.   Nature Protocols

Analyzing and interpreting genome data at the network level with ConsensusPathDB

(2016) Ralf Herwig et al.   Nature Protocols

Promoter Variation and Expression Levels of Inflammatory Genes IL1A, IL1B, IL6 and TNF in Blood of Spinocerebellar Ataxia Type 3 (SCA3) Patients

(2016) Mafalda Raposo et al.   NEUROMOLECULAR MEDICINE

Detection and visualization of differential splicing in RNA-Seq data with JunctionSeq

(2016) Stephen W. Hartley et al.   NUCLEIC ACIDS RESEARCH

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(2016)   NUCLEIC ACIDS RESEARCH

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(2016) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Multiomic Analysis of the UV-Induced DNA Damage Response

(2016) Stefan Boeing et al.   Cell Reports

Down-regulation of p21-activated serine/threonine kinase 1 is involved in loss of mesencephalic dopamine neurons

(2016) Hwanhee Kim et al.   Molecular Brain

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

(2016) Maxime WC Rousseaux et al.   eLife

QoRTs: a comprehensive toolset for quality control and data processing of RNA-Seq experiments

(2015) Stephen W. Hartley et al.   BMC BIOINFORMATICS

The Role of the Pleckstrin Homology Domain-containing Protein CKIP-1 in Activation of p21-activated Kinase 1 (PAK1)

(2015) Yong-Bae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polarized activities of AMPK and BRSK in primary hippocampal neurons

(2015) Vedangi Sample et al.   MOLECULAR BIOLOGY OF THE CELL

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD

(2015) Pawel M. Switonski et al.   NEUROBIOLOGY OF DISEASE

Building the Neuronal Microtubule Cytoskeleton

(2015) Lukas C. Kapitein et al.   NEURON

Inhibition of Nischarin Expression Promotes Neurite Outgrowth through Regulation of PAK Activity

(2015) Yuemin Ding et al.   PLoS One

Cytoplasmic poly(A) binding protein-1 binds to genomically encoded sequences within mammalian mRNAs

(2015) Hemant K. Kini et al.   RNA

Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3

(2015) Rui Gao et al.   PLoS Genetics

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

(2015) Arpita Chatterjee et al.   PLoS Genetics

Change in the Cortical Complexity of Spinocerebellar Ataxia Type 3 Appears Earlier than Clinical Symptoms

(2015) Tzu-Yun Wang et al.   PLoS One

Loss of DDB1 Leads to Transcriptional p53 Pathway Activation in Proliferating Cells, Cell Cycle Deregulation, and Apoptosis in Zebrafish Embryos

(2015) Zhilian Hu et al.   PLoS One

Polyglutamine-expanded ataxin-3 impairs long-term depression in Purkinje neurons of SCA3 transgenic mouse by inhibiting HAT and impairing histone acetylation

(2014) An-Hsun Chou et al.   BRAIN RESEARCH

Cerebral cortex involvement in Machado−Joseph disease

(2014) T. J. R. de Rezende et al.   EUROPEAN JOURNAL OF NEUROLOGY

Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain

(2014) E. M. Gibson et al.   SCIENCE

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(2013) Gabriela Bindea et al.   BIOINFORMATICS

Conversion of a Signal into Forces for Axon Outgrowth through Pak1-Mediated Shootin1 Phosphorylation

(2013) Michinori Toriyama et al.   CURRENT BIOLOGY

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(2012) Alexander Dobin et al.   BIOINFORMATICS

Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3)

(2012) J. Hubener et al.   HUMAN MOLECULAR GENETICS

L1CAM increases MAP2 expression via the MAPK pathway to promote neurite outgrowth

(2012) Gunnar Heiko Dirk Poplawski et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mouse Models of Polyglutamine Diseases: Review and Data Table. Part I

(2012) Maciej Figiel et al.   MOLECULAR NEUROBIOLOGY

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(2012) Pawel M. Switonski et al.   MOLECULAR NEUROBIOLOGY

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(2012) Ravi K. Patel et al.   PLoS One

Axon injury and stress trigger a microtubule-based neuroprotective pathway

(2012) L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado–Joseph disease

(2011) Isabel Nascimento-Ferreira et al.   BRAIN

Body Mass Index is Inversely Correlated with the Expanded CAG Repeat Length in SCA3/MJD Patients

(2011) Jonas Alex Morales Saute et al.   CEREBELLUM

FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3

(2011) Julieta Araujo et al.   HUMAN MOLECULAR GENETICS

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado–Joseph disease

(2011) Philipp Koch et al.   NATURE

Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations

(2011) I. Peixeiro et al.   NUCLEIC ACIDS RESEARCH

A Directed Protein Interaction Network for Investigating Intracellular Signal Transduction

(2011) A. Vinayagam et al.   Science Signaling

Axonal inclusions in spinocerebellar ataxia type 3

(2010) Kay Seidel et al.   ACTA NEUROPATHOLOGICA

Analysis of the signaling pathways regulating Src-dependent remodeling of the actin cytoskeleton

(2010) Sabina E. Winograd-Katz et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Activity and Cellular Functions of the Deubiquitinating Enzyme and Polyglutamine Disease Protein Ataxin-3 Are Regulated by Ubiquitination at Lysine 117

(2010) Sokol V. Todi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia

(2010) Stephan J. Guyenet et al.   Jove-Journal of Visualized Experiments

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(2009) Gabriela Bindea et al.   BIOINFORMATICS

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(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin

(2009) Serena Mazzucchelli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease

(2009) Ya-Chun Yu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

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(2009) E Lomonosova et al.   ONCOGENE

A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration

(2009) P. Koch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SCA3: Neurological features, pathogenesis and animal models

(2008) Olaf Riess et al.   CEREBELLUM

The Deubiquitinating Enzyme Ataxin-3, a Polyglutamine Disease Protein, Edits Lys63Linkages in Mixed Linkage Ubiquitin Chains

(2008) Brett J. Winborn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pre-assembled tau filaments phosphorylated by GSK-3b form large tangle-like structures

(2008) Carolyn A. Rankin et al.   NEUROBIOLOGY OF DISEASE

Study of subcellular localization and proteolysis of ataxin-3

(2008) Chiara Pozzi et al.   NEUROBIOLOGY OF DISEASE

Casein kinase 2 interacts with and phosphorylates ataxin-3

(2008) Rui-Song Tao et al.   Neuroscience Bulletin