Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model
Authors
Keywords
Spinocerebellar ataxia type 3, Mouse model, RNA sequencing, Metabolomics
Journal
Molecular Neurodegeneration
Volume 13, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-06-22
DOI
10.1186/s13024-018-0261-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Gene co-expression network analysis for identifying modules and functionally enriched pathways in SCA2
- (2017) Lance T. Pflieger et al. HUMAN MOLECULAR GENETICS
- Comparison of spinocerebellar ataxia type 3 mouse models identifies early gain-of-function, cell-autonomous transcriptional changes in oligodendrocytes
- (2017) Biswarathan Ramani et al. HUMAN MOLECULAR GENETICS
- Huntingtin gene repeat size variations affect risk of lifetime depression
- (2017) Sarah L. Gardiner et al. Translational Psychiatry
- Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 Mice
- (2017) Lodewijk J.A. Toonen et al. Molecular Therapy-Nucleic Acids
- Triploid atlantic salmon (Salmo salar L.) post-smolts accumulate prevalence more slowly than diploid salmon following bath challenge with salmonid alphavirus subtype 3
- (2017) Lindsey J. Moore et al. PLoS One
- Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington’s disease peripheral blood samples
- (2016) Anastasios Mastrokolias et al. Metabolomics
- Annotation of the human cerebrospinal fluid lipidome using high resolution mass spectrometry and a dedicated data processing workflow
- (2016) Alexandre Seyer et al. Metabolomics
- Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels
- (2016) Nesli Ece Sen et al. NEUROBIOLOGY OF DISEASE
- Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways
- (2016) Melissa Ingram et al. NEURON
- Metabolic Biomarkers and Neurodegeneration: A Pathway Enrichment Analysis of Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis
- (2016) Medi Kori et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Common disease signatures from gene expression analysis in Huntington’s disease human blood and brain
- (2016) Eleni Mina et al. Orphanet Journal of Rare Diseases
- Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3
- (2016) Lodewijk J. A. Toonen et al. Scientific Reports
- The impairment of cholesterol metabolism in Huntington disease
- (2015) Valerio Leoni et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Huntington’s disease biomarker progression profile identified by transcriptome sequencing in peripheral blood
- (2015) Anastasios Mastrokolias et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Novel candidate blood-based transcriptional biomarkers of machado-joseph disease
- (2015) Mafalda Raposo et al. MOVEMENT DISORDERS
- T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse
- (2015) An-Hsun Chou et al. NEUROPHARMACOLOGY
- Annotation of the human serum metabolome by coupling three liquid chromatography methods to high-resolution mass spectrometry
- (2014) Samia Boudah et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Toward RNAi Therapy for the Polyglutamine Disease Machado–Joseph Disease
- (2013) Maria do Carmo Costa et al. MOLECULAR THERAPY
- Association between Machado–Joseph disease and oxidative stress biomarkers
- (2013) Laura Segabinazzi Pacheco et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- Removing technical variability in RNA-seq data using conditional quantile normalization
- (2012) K. D. Hansen et al. BIOSTATISTICS
- Inhibition of Lipid Signaling Enzyme Diacylglycerol Kinase ϵ Attenuates Mutant Huntingtin Toxicity
- (2012) Ningzhe Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Patterns of Mitochondrial DNA Damage in Blood and Brain Tissues of a Transgenic Mouse Model of Machado-Joseph Disease
- (2012) Nadiya Kazachkova et al. Neurodegenerative Diseases
- Whole-Brain Mapping of Direct Inputs to Midbrain Dopamine Neurons
- (2012) Mitsuko Watabe-Uchida et al. NEURON
- Summarizing and correcting the GC content bias in high-throughput sequencing
- (2012) Yuval Benjamini et al. NUCLEIC ACIDS RESEARCH
- Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease
- (2011) Albert Giralt et al. HUMAN MOLECULAR GENETICS
- Early Changes in Cerebellar Physiology Accompany Motor Dysfunction in the Polyglutamine Disease Spinocerebellar Ataxia Type 3
- (2011) V. G. Shakkottai et al. JOURNAL OF NEUROSCIENCE
- Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry
- (2011) Warwick B Dunn et al. Nature Protocols
- Polyglutamine diseases: The special case of ataxin-3 and Machado–Joseph disease
- (2011) Carlos A. Matos et al. PROGRESS IN NEUROBIOLOGY
- The role of CREB signaling in Alzheimer’s disease and other cognitive disorders
- (2011) Carlos A. Saura et al. REVIEWS IN THE NEUROSCIENCES
- Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination
- (2011) Mangala M. Soundarapandian et al. Scientific Reports
- A scaling normalization method for differential expression analysis of RNA-seq data
- (2010) Mark D Robinson et al. GENOME BIOLOGY
- edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
- (2009) M. D. Robinson et al. BIOINFORMATICS
- Altered cholesterol and fatty acid metabolism in Huntington disease
- (2009) Robert C. Block et al. Journal of Clinical Lipidology
- Blood levels of kynurenines, interleukin-23 and soluble human leucocyte antigen-G at different stages of Huntington’s disease
- (2009) Caroline M. Forrest et al. JOURNAL OF NEUROCHEMISTRY
- Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease
- (2009) Ya-Chun Yu et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Polyglutamine-expanded ataxin-7 causes cerebellar dysfunction by inducing transcriptional dysregulation
- (2009) An-Hsun Chou et al. NEUROCHEMISTRY INTERNATIONAL
- Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data
- (2009) J. M. Ruijter et al. NUCLEIC ACIDS RESEARCH
- Transcription Factors in Long-Term Memory and Synaptic Plasticity
- (2009) Cristina M. Alberini PHYSIOLOGICAL REVIEWS
- Regulation of ceramide-induced neuronal death: Cell metabolism meets neurodegeneration
- (2008) Gonzalo Arboleda et al. BRAIN RESEARCH REVIEWS
- SCA3: Neurological features, pathogenesis and animal models
- (2008) Olaf Riess et al. CEREBELLUM
- Deranged Calcium Signaling and Neurodegeneration in Spinocerebellar Ataxia Type 3
- (2008) X. Chen et al. JOURNAL OF NEUROSCIENCE
- Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation
- (2008) An-Hsun Chou et al. NEUROBIOLOGY OF DISEASE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started