Roles of Inflammasomes in Inflammatory Kidney Diseases

Cells under stress: The mechanical environment shapes inflammasome responses to danger signals

(2019) Hemant Joshi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammasomes, Autophagy, and Cell Death: The Trinity of Innate Host Defense against Intracellular Bacteria

(2019) Teresa Krakauer   MEDIATORS OF INFLAMMATION

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes

(2019) Andrew Sandstrom et al.   SCIENCE

The role of lysosomal cysteine cathepsins in NLRP3 inflammasome activation

(2019) Rhiannon I. Campden et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Harmine mitigates LPS-induced acute kidney injury through inhibition of the TLR4-NF-κB/NLRP3 inflammasome signalling pathway in mice

(2019) Xiaofeng Niu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin attenuates murine lupus via inhibiting NLRP3 inflammasome

(2019) Jijun Zhao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions

(2019) Wan-Han Hsu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries

(2019) Patrick S Mitchell et al.   CURRENT OPINION IN IMMUNOLOGY

Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD

(2018) Takanori Komada et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1–mediated tissue injury

(2018) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation

(2018) Tao-Tao Tang et al.   Cell Death & Disease

Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16

(2018) Pei‐Hui Wang et al.   EMBO REPORTS

Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice

(2018) Wu Song et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Artemisinin attenuates tubulointerstitial inflammation and fibrosis via the NF-κB/NLRP3 pathway in rats with 5/6 subtotal nephrectomy

(2018) Yi Wen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice

(2018) Ming Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Inflammation-Related Mechanisms in Chronic Kidney Disease Prediction, Progression, and Outcome

(2018) Simona Mihai et al.   Journal of Immunology Research

Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome

(2018) Xiaofei Peng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Stressing out the mitochondria: Mechanistic insights into NLRP3 inflammasome activation

(2018) Monica Yabal et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

(2018) Jueqi Chen et al.   NATURE

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

NLRP3 inflammasome activation regulated by NF-κB and DAPK contributed to paraquat-induced acute kidney injury

(2017) Zhenning Liu et al.   IMMUNOLOGIC RESEARCH

Mechanisms governing inflammasome activation, assembly and pyroptosis induction

(2017) Sannula Kesavardhana et al.   INTERNATIONAL IMMUNOLOGY

Molecular mechanisms of inflammasome signaling

(2017) Anukriti Mathur et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Toll-like receptor-4 signaling mediates inflammation and tissue injury in diabetic nephropathy

(2017) Giacomo Garibotto et al.   JOURNAL OF NEPHROLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective

(2017) Vaishali R. Moulton et al.   TRENDS IN MOLECULAR MEDICINE

AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA

(2017) Yuki Nakaya et al.   mBio

Meta-analysis of the association between NLRP1 polymorphisms and the susceptibility to vitiligo and associated autoimmune diseases

(2017) Juan Li et al.   Oncotarget

NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy

(2017) Yu-Ling Tsai et al.   Scientific Reports

Podocyte Activation of NLRP3 Inflammasomes Contributes to the Development of Proteinuria in Lupus Nephritis

(2017) Rong Fu et al.   Arthritis & Rheumatology

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways

(2016) Shuk-Man Ka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Allopurinol attenuates rhabdomyolysis-associated acute kidney injury: Renal and muscular protection

(2016) Pedro H.F. Gois et al.   FREE RADICAL BIOLOGY AND MEDICINE

The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA

(2016) Elizabeth E. Gray et al.   IMMUNITY

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Of Inflammasomes and Alarmins: IL-1  and IL-1  in Kidney Disease

(2016) H.-J. Anders   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Anti-dsDNA antibodies bind to TLR4 and activate NLRP3 inflammasome in lupus monocytes/macrophages

(2016) Hui Zhang et al.   Journal of Translational Medicine

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice

(2016) Isis Ludwig-Portugall et al.   KIDNEY INTERNATIONAL

Is the inflammasome relevant for epithelial cell function?

(2016) Patricia T. Santana et al.   MICROBES AND INFECTION

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

(2016) Yuan He et al.   NATURE

Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy

(2016) Yuan-ye Qiu et al.   PHARMACOLOGICAL RESEARCH

High Glucose and Lipopolysaccharide Prime NLRP3 Inflammasome via ROS/TXNIP Pathway in Mesangial Cells

(2016) Hong Feng et al.   Journal of Diabetes Research

Involvement of the NLRC4-Inflammasome in Diabetic Nephropathy

(2016) Fang Yuan et al.   PLoS One

NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy

(2016) Justin Chun et al.   Scientific Reports

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

(2015) Si Ming Man et al.   CELL

Role of the nucleotide-binding domain-like receptor protein 3 inflammasome in acute kidney injury

(2015) Yanhui Cao et al.   FEBS Journal

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Inflammasomes in host response to protozoan parasites

(2015) Dario S. Zamboni et al.   IMMUNOLOGICAL REVIEWS

The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus

(2015) Yue Zhao et al.   IMMUNOLOGICAL REVIEWS

Safety and Efficacy of an Oral Inhibitor of the Purinergic Receptor P2X7 in Adult Patients with Moderately to Severely Active Crohnʼs Disease

(2015) Alexander Eser et al.   INFLAMMATORY BOWEL DISEASES

Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy

(2015) Ya-Ping Chang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β

(2015) Man Lyang Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells

(2015) Ravichandran Panchanathan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

(2015) Hexin Shi et al.   NATURE IMMUNOLOGY

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

(2015) Justin E Wilson et al.   NATURE MEDICINE

Innate immunity in diabetes and diabetic nephropathy

(2015) Jun Wada et al.   Nature Reviews Nephrology

Acute Poststreptococcal Glomerulonephritis: The Most Common Acute Glomerulonephritis

(2015) René G. VanDeVoorde   PEDIATRICS IN REVIEW

Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation

(2015) Shuk-Man Ka et al.   ARTHRITIS RESEARCH & THERAPY

NADPH Oxidase-Induced NALP3 Inflammasome Activation Is Driven by Thioredoxin-Interacting Protein Which Contributes to Podocyte Injury in Hyperglycemia

(2015) Pan Gao et al.   Journal of Diabetes Research

Rotenone Attenuates Renal Injury in Aldosterone-Infused Rats by Inhibiting Oxidative Stress, Mitochondrial Dysfunction, and Inflammasome Activation

(2015) Wei Ding et al.   MEDICAL SCIENCE MONITOR

Horizon 2020 in Diabetic Kidney Disease: The Clinical Trial Pipeline for Add-On Therapies on Top of Renin Angiotensin System Blockade

(2015) Maria Perez-Gomez et al.   Journal of Clinical Medicine

NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-β receptor signalling

(2014) Maciej Lech et al.   ANNALS OF THE RHEUMATIC DISEASES

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

Thioredoxin-interacting protein mediates NALP3 inflammasome activation in podocytes during diabetic nephropathy

(2014) Pan Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

The inflammasome and lupus

(2014) J. Michelle Kahlenberg et al.   CURRENT OPINION IN RHEUMATOLOGY

Type I Interferon Signaling Regulates Activation of the Absent in Melanoma 2 Inflammasome during Streptococcus pneumoniae Infection

(2014) R. Fang et al.   INFECTION AND IMMUNITY

Nod-like Receptor Protein 3 (NLRP3) Inflammasome Activation and Podocyte Injury via Thioredoxin-Interacting Protein (TXNIP) during Hyperhomocysteinemia

(2014) Justine M. Abais et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

The high-mobility group protein B1–Toll-like receptor 4 pathway contributes to the acute lung injury induced by bilateral nephrectomy

(2014) Kent Doi et al.   KIDNEY INTERNATIONAL

Molecular Basis for Specific Recognition of Bacterial Ligands by NAIP/NLRC4 Inflammasomes

(2014) Jeannette L. Tenthorey et al.   MOLECULAR CELL

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Sex-dependent differential activation of NLRP3 and AIM2 inflammasomes in SLE macrophages

(2014) C.-A. Yang et al.   RHEUMATOLOGY

Inflammasomes

(2014) M. R. de Zoete et al.   Cold Spring Harbor Perspectives in Biology

P2X7Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

(2013) Jijun Zhao et al.   ARTHRITIS AND RHEUMATISM

Structural basis for termination of AIM2-mediated signaling by p202

(2013) Heng Ru et al.   CELL RESEARCH

Histones trigger sterile inflammation by activating the NLRP3 inflammasome

(2013) Ramanjaneyulu Allam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome

(2013) Shun-Min Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human astrocytes express a novel NLRP2 inflammasome

(2013) Julia Minkiewicz et al.   GLIA

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

ATP-P2X4 signaling mediates NLRP3 inflammasome activation: A novel pathway of diabetic nephropathy

(2013) Kehong Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

AIM2 Facilitates the Apoptotic DNA-induced Systemic Lupus Erythematosus via Arbitrating Macrophage Functional Maturation

(2013) Weijuan Zhang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Self Double-Stranded (ds)DNA Induces IL-1  Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti-dsDNA Antibodies

(2013) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

The purinergic 2X7receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation

(2013) Anna Solini et al.   JOURNAL OF PATHOLOGY

Podocytes Are Nonhematopoietic Professional Antigen-Presenting Cells

(2013) A. Goldwich et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AIM2, an IFN-Inducible Cytosolic DNA Sensor, in the Development of Benign Prostate Hyperplasia and Prostate Cancer

(2013) Larissa Ponomareva et al.   MOLECULAR CANCER RESEARCH

Nuclear DNA Sensor IFI16 as Circulating Protein in Autoimmune Diseases Is a Signal of Damage that Impairs Endothelial Cells through High-Affinity Membrane Binding

(2013) Francesca Gugliesi et al.   PLoS One

Osthole Mitigates Progressive IgA Nephropathy by Inhibiting Reactive Oxygen Species Generation and NF-κB/NLRP3 Pathway

(2013) Kuo-Feng Hua et al.   PLoS One

Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation

(2013) Qian Yin et al.   Cell Reports

Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms

(2013) Petr Broz et al.   PLoS Pathogens

Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor

(2013) Joseph Chavarría-Smith et al.   PLoS Pathogens

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

(2012) Edward C Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

Polimorphisms in Inflammasome Genes Are Involved in the Predisposition to Systemic Lupus Erythematosus

(2012) Alessandra Pontillo et al.   AUTOIMMUNITY

The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses

(2012) Masaaki Iwata et al.   BRAIN BEHAVIOR AND IMMUNITY

Association between Albuminuria, Kidney Function, and Inflammatory Biomarker Profile in CKD in CRIC

(2012) J. Gupta et al.   Clinical Journal of the American Society of Nephrology

Activation of Nod-Like Receptor Protein 3 Inflammasomes Turns on Podocyte Injury and Glomerular Sclerosis in Hyperhomocysteinemia

(2012) Chun Zhang et al.   HYPERTENSION

The NLRP12 Inflammasome Recognizes Yersinia pestis

(2012) Gregory I. Vladimer et al.   IMMUNITY

NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells

(2012) Seth L. Masters et al.   IMMUNITY

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

(2012) Rebecca L. Brunette et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Complement Protein C1q Directs Macrophage Polarization and Limits Inflammasome Activity during the Uptake of Apoptotic Cells

(2012) M. E. Benoit et al.   JOURNAL OF IMMUNOLOGY

Efficacy and Safety of CE-224,535, an Antagonist of P2X7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate

(2012) T. C. STOCK et al.   JOURNAL OF RHEUMATOLOGY

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

(2012) Jonathan L. Levinsohn et al.   PLoS Pathogens

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

(2011) Eran Elinav et al.   CELL

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

The Inflammasomes in Kidney Disease

(2011) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dangers Within: DAMP Responses to Damage and Cell Death in Kidney Disease

(2011) D. L. Rosin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: Implications for the regulation of innate immune responses in SLE

(2011) Ravichandran Panchanathan et al.   MOLECULAR IMMUNOLOGY

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

IFI16 Protein Mediates the Anti-inflammatory Actions of the Type-I Interferons through Suppression of Activation of Caspase-1 by Inflammasomes

(2011) Sudhakar Veeranki et al.   PLoS One

Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

(2011) Y. Dombrowski et al.   Science Translational Medicine

NLRP3 E311K mutation in a large family with Muckle-Wells syndrome - description of a heterogeneous phenotype and response to treatment

(2011) Jasmin B Kuemmerle-Deschner et al.   ARTHRITIS RESEARCH & THERAPY

Auranofin Protects against Anthrax Lethal Toxin-Induced Activation of the Nlrp1b Inflammasome

(2010) Zachary L. Newman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aim2 Deficiency Stimulates the Expression of IFN-Inducible Ifi202, a Lupus Susceptibility Murine Gene within the Nba2 Autoimmune Susceptibility Locus

(2010) R. Panchanathan et al.   JOURNAL OF IMMUNOLOGY

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

(2010) A. A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Interferon-α and -β in kidney inflammation

(2010) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

(2010) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR

(2009) I Kimkong et al.   LUPUS

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

(2009) Hendrik Poeck et al.   NATURE IMMUNOLOGY

Use of Canakinumab in the Cryopyrin-Associated Periodic Syndrome

(2009) Helen J. Lachmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Upregulated IL-18 expression in type 2 diabetic subjects with nephropathy: TGF-β1 enhanced IL-18 expression in human renal proximal tubular epithelial cells

(2008) Kazunari Miyauchi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Th17 cells: a new fate for differentiating helper T cells

(2008) Zhi Chen et al.   IMMUNOLOGIC RESEARCH

The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis

(2008) Rieke Alten et al.   ARTHRITIS RESEARCH & THERAPY