Osthole Mitigates Progressive IgA Nephropathy by Inhibiting Reactive Oxygen Species Generation and NF-κB/NLRP3 Pathway

NF-kB Expression in IgA Nephropathy Outcome

(2013) G. E. B. Silva et al.   DISEASE MARKERS

Osthole protects lipopolysaccharide-induced acute lung injury in mice by preventing down-regulation of angiotensin-converting enzyme 2

(2013) Yun Shi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Antroquinonol mitigates an accelerated and progressive IgA nephropathy model in mice by activating the Nrf2 pathway and inhibiting T cells and NLRP3 inflammasome

(2013) Shun-Min Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Renal macrophage infiltration is associated with a poor outcome in IgA nephropathy

(2012) GEB Silva et al.   Clinics

Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretion

(2012) Pei-Chun Liao et al.   INFLAMMATION RESEARCH

High glucose increases nitric oxide generation in lipopolysaccharide-activated macrophages by enhancing activity of protein kinase C-α/δ and NF-κB

(2012) Kuo-Feng Hua et al.   INFLAMMATION RESEARCH

Spleen Tyrosine Kinase Is Important in the Production of Proinflammatory Cytokines and Cell Proliferation in Human Mesangial Cells following Stimulation with IgA1 Isolated from IgA Nephropathy Patients

(2012) M. J. Kim et al.   JOURNAL OF IMMUNOLOGY

Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis

(2011) Pei-Yi Tsai et al.   ARTHRITIS AND RHEUMATISM

Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats

(2011) Yalong He et al.   BRAIN RESEARCH

Length and site of the small intestine exposed to fat influences hunger and food intake

(2011) P. W. Jeroen Maljaars et al.   BRITISH JOURNAL OF NUTRITION

Oxidative Stress and Galactose-Deficient IgA1 as Markers of Progression in IgA Nephropathy

(2011) R. Camilla et al.   Clinical Journal of the American Society of Nephrology

Nrf2 Activators as Attractive Therapeutics for Diabetic Nephropathy: FIG. 1.

(2011) Judy B. de Haan   DIABETES

Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice

(2011) S. M. Ka et al.   DIABETOLOGIA

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone

(2011) Joseph CK Leung et al.   Journal of Translational Medicine

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1

(2011) Julia Lichtnekert et al.   PLoS One

Reduction of isoprenaline-induced myocardial TGF-β1 expression and fibrosis in osthole-treated mice

(2011) Rong Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats

(2010) Xiaodong Chao et al.   BRAIN RESEARCH

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of adaptive immunity by the NLRP3 inflammasome

(2010) Mingkuan Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Osthole Regulates Inflammatory Mediator Expression through Modulating NF-κB, Mitogen-Activated Protein Kinases, Protein Kinase C, and Reactive Oxygen Species

(2010) Pei-Chun Liao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oxidative Stress in IgA Nephropathy

(2010) R. Coppo et al.   NEPHRON CLINICAL PRACTICE

Additive effect of PPAR-γ agonist and ARB in treatment of experimental IgA nephropathy

(2010) Kar Neng Lai et al.   PEDIATRIC NEPHROLOGY

Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress

(2010) Jianjun Zhang et al.   PHYTOTHERAPY RESEARCH

ACTIVATION OF REACTIVE OXYGEN SPECIES AND THE RENIN-ANGIOTENSIN SYSTEM IN IgA NEPHROPATHY MODEL MICE

(2009) Naro Ohashi et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin

(2009) Xiaohong Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of osthole on apoptosis and TGF-β1of hypertrophic scar fibroblasts

(2009) Xiao-Hua Hou et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Macromolecular IgA1 taken from patients with familial IgA Nephropathy or their asymptomatic relatives have higher reactivity to mesangial cells in vitro

(2009) Ka Ying Tam et al.   KIDNEY INTERNATIONAL

Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy

(2009) Won Ho Hahn et al.   PEDIATRIC NEPHROLOGY

The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal prognosis in IgA nephropathy

(2007) D.D. Torres et al.   KIDNEY INTERNATIONAL