Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties

Overview of the Structure–Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi

(2019) Annick Barre et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Messages From the Past: New Insights in Plant Lectin Evolution

(2019) Sofie Van Holle et al.   Frontiers in Plant Science

Design of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis

(2019) Haitao Yang et al.   Pharmaceutics

Involvement of the dopaminergic system in the antidepressant-like effect of the lectin isolated from the red marine alga Solieria filiformis in mice

(2018) Ticiana Monteiro Abreu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Structural characterization of two isolectins from the marine red alga Solieria filiformis (Kützing) P.W. Gabrielson and their anticancer effect on MCF-7 breast cancer cells

(2018) Renata Pinheiro Chaves et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Meristiella echinocarpa lectin (MEL): a new member of the OAAH-lectin family

(2018) Renata Pinheiro Chaves et al.   JOURNAL OF APPLIED PHYCOLOGY

Development of a Vaginal Fast-Dissolving Insert Combining Griffithsin and Carrageenan for Potential Use Against Sexually Transmitted Infections

(2018) Manjari Lal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evolutionary and genomic analysis of the caleosin/peroxygenase (CLO/PXG) gene/protein families in the Viridiplantae

(2018) Farzana Rahman et al.   PLoS One

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm

(2018) Evangelia Vamvaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

(2018) Nina Derby et al.   Nature Communications

Evolutionary Dynamics of Cryptophyte Plastid Genomes

(2017) Jong Im Kim et al.   Genome Biology and Evolution

Lectins from red algae and their biomedical potential

(2017) Ram Sarup Singh et al.   JOURNAL OF APPLIED PHYCOLOGY

A Novel High-Mannose Specific Lectin from the Green Alga Halimeda renschii Exhibits a Potent Anti-Influenza Virus Activity through High-Affinity Binding to the Viral Hemagglutinin

(2017) Jinmin Mu et al.   Marine Drugs

Insights into the red algae and eukaryotic evolution from the genome ofPorphyra umbilicalis(Bangiophyceae, Rhodophyta)

(2017) Susan H. Brawley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kingdom Chromista and its eight phyla: a new synthesis emphasising periplastid protein targeting, cytoskeletal and periplastid evolution, and ancient divergences

(2017) Thomas Cavalier-Smith   PROTOPLASMA

Mass spectrometric profiling reveals association of N-glycan patterns with epithelial ovarian cancer progression

(2017) Huanhuan Chen et al.   TUMOR BIOLOGY

Increased expression of the high‑mannose M6N2 and NeuAc3H3N3M3N2F tri‑antennary N‑glycans in cholangiocarcinoma

(2017) Krajang Talabnin et al.   Oncology Letters

Fabrication and Characterization of Griffithsin-modified Fiber Scaffolds for Prevention of Sexually Transmitted Infections

(2017) Hung R. Vuong et al.   Jove-Journal of Visualized Experiments

Griffithsin-Modified Electrospun Fibers as a Delivery Scaffold To Prevent HIV Infection

(2016) Tiffany N. Grooms et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural analysis of Centrolobium tomentosum seed lectin with inflammatory activity

(2016) Alysson Chaves Almeida et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

(2016) Guillaume B.E. Stewart-Jones et al.   CELL

Erratum to: High-Mannose Specific Lectin and Its Recombinants from a Carrageenophyta Kappaphycus alvarezii Represent a Potent Anti-HIV Activity Through High-Affinity Binding to the Viral Envelope Glycoprotein gp120

(2016) Makoto Hirayama et al.   MARINE BIOTECHNOLOGY

Antinociceptive and Anti-inflammatory Activities of the Lectin from Marine Red Alga Solieria filiformis

(2016) Ticiana Abreu et al.   PLANTA MEDICA

Pharmacokinetics of the Antiviral Lectin Griffithsin Administered by Different Routes Indicates Multiple Potential Uses

(2016) Christopher Barton et al.   Viruses-Basel

Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses

(2016) Joseph Kouokam et al.   Viruses-Basel

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus

(2015) Keith Levendosky et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mass spectrometry-based N-linked glycomic profiling as a means for tracking pancreatic cancer metastasis

(2015) Hae-Min Park et al.   CARBOHYDRATE RESEARCH

Entry Inhibition of Influenza Viruses with High Mannose Binding Lectin ESA-2 from the Red Alga Eucheuma serra through the Recognition of Viral Hemagglutinin

(2015) Yuichiro Sato et al.   Marine Drugs

Lectins with Anti-HIV Activity: A Review

(2015) Ouafae Akkouh et al.   MOLECULES

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

(2015) Tinoush Moulaei et al.   Retrovirology

The Characteristic Structure of Anti-HIV Actinohivin in Complex with Three HMTG D1 Chains of HIV-gp120

(2014) Fang Zhang et al.   CHEMBIOCHEM

Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family

(2014) Geoffrey Férir et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Purification, primary structure, and biological activity of the high-mannose N-glycan-specific lectin from cultivated Eucheuma denticulatum

(2014) Le Dinh Hung et al.   JOURNAL OF APPLIED PHYCOLOGY

N-glycomic Profiling as a Tool to Separate Rectal Adenomas from Carcinomas

(2014) Tuomas Kaprio et al.   MOLECULAR & CELLULAR PROTEOMICS

The Griffithsin Dimer Is Required for High-Potency Inhibition of HIV-1: Evidence for Manipulation of the Structure of gp120 as Part of the Griffithsin Dimer Mechanism

(2013) Jie Xue et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of and Effect of Subcutaneous Treatment with the Broad-Spectrum Antiviral Lectin Griffithsin in Two Laboratory Rodent Models

(2013) Christopher Barton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Glycomic Approach for Potential Biomarkers on Prostate Cancer: Profiling of N-Linked Glycans in Human Sera and pRNS Cell Lines

(2013) Maria Lorna A. de Leoz et al.   DISEASE MARKERS

Comparative N-Glycan Profiling of Colorectal Cancer Cell Lines Reveals Unique Bisecting GlcNAc and α-2,3-Linked Sialic Acid Determinants Are Associated with Membrane Proteins of the More Metastatic/Aggressive Cell Lines

(2013) Manveen K. Sethi et al.   JOURNAL OF PROTEOME RESEARCH

Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread

(2013) B. Nixon et al.   JOURNAL OF VIROLOGY

Chromosome Scale Genome Assembly and Transcriptome Profiling of Nannochloropsis gaditana in Nitrogen Depletion

(2013) Elisa Corteggiani Carpinelli et al.   Molecular Plant

Antiviral Lectins from Red and Blue-Green Algae Show Potent In Vitro and In Vivo Activity against Hepatitis C Virus

(2013) Yutaka Takebe et al.   PLoS One

Role of the Carbohydrate-Binding Sites of Griffithsin in the Prevention of DC-SIGN-Mediated Capture and Transmission of HIV-1

(2013) Bart Hoorelbeke et al.   PLoS One

Cell Surface-Specific N-Glycan Profiling in Breast Cancer

(2013) Xia Liu et al.   PLoS One

Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains

(2012) Geoffrey Férir et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Algal Lectins as Potential HIV Microbicide Candidates

(2012) Dana Huskens et al.   Marine Drugs

Characterization of Isoforms of the Lectin Isolated from the Red Algae Bryothamnion seaforthii and Its Pro-Healing Effect

(2012) Luiz Gonzaga do Nascimento-Neto et al.   Marine Drugs

The Role of Individual Carbohydrate-Binding Sites in the Function of the Potent Anti-HIV Lectin Griffithsin

(2012) Jie Xue et al.   MOLECULAR PHARMACEUTICS

Griffithsin Has Antiviral Activity against Hepatitis C Virus

(2011) Philip Meuleman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High mannose-specific lectin (KAA-2) from the red alga Kappaphycus alvarezii potently inhibits influenza virus infection in a strain-independent manner

(2011) Yuichiro Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural basis for both pro- and anti-inflammatory response induced by mannose-specific legume lectin from Cymbosema roseum

(2011) Bruno A.M. Rocha et al.   BIOCHIMIE

Solution Structure of the Monovalent Lectin Microvirin in Complex with Manα(1–2)Man Provides a Basis for Anti-HIV Activity with Low Toxicity

(2011) Syed Shahzad-ul-Hussan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Mannose-binding Lectin with Preference for the Cluster of α1–2-Mannose from the Green AlgaBoodlea coactaIs a Potent Entry Inhibitor of HIV-1 and Influenza Viruses

(2011) Yuichiro Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fast docking using the CHARMM force field with EADock DSS

(2011) Aurélien Grosdidier et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin

(2011) X. Huang et al.   JOURNAL OF GENERAL VIROLOGY

Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site

(2011) K. B. Alexandre et al.   JOURNAL OF VIROLOGY

SwissDock, a protein-small molecule docking web service based on EADock DSS

(2011) A. Grosdidier et al.   NUCLEIC ACIDS RESEARCH

High-mannose N-glycan-specific lectin from the red alga Kappaphycus striatum (Carrageenophyte)

(2011) Le Dinh Hung et al.   PHYTOCHEMISTRY

Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate

(2011) Joseph Calvin Kouokam et al.   PLoS One

Structural Basis of the Anti-HIV Activity of the Cyanobacterial Oscillatoria Agardhii Agglutinin

(2011) Leonardus M.I. Koharudin et al.   STRUCTURE

Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C

(2011) Geoffrey Férir et al.   VIROLOGY

The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4+ cells

(2011) Kabamba B. Alexandre et al.   VIROLOGY

Toward the estimation of the absolute quality of individual protein structure models

(2010) Pascal Benkert et al.   BIOINFORMATICS

Bioinformatics and molecular modeling in glycobiology

(2010) Martin Frank et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

In vitro and in vivo anti-tumor effects of novel Span 80 vesicles containing immobilized Eucheuma serra agglutinin

(2010) Yousuke Omokawa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Novel Fold and Carbohydrate Specificity of the Potent Anti-HIV Cyanobacterial Lectin fromOscillatoria agardhii

(2010) Leonardus M. I. Koharudin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-Mannose Glycans are Elevated during Breast Cancer Progression

(2010) Maria Lorna A. de Leoz et al.   MOLECULAR & CELLULAR PROTEOMICS

Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin

(2010) Ewa D. Micewicz et al.   PLoS One

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

(2010) Tinoush Moulaei et al.   STRUCTURE

Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin

(2010) Kabamba B. Alexandre et al.   VIROLOGY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

(2009) B. R. O'Keefe et al.   JOURNAL OF VIROLOGY

Mechanism by which the lectin actinohivin blocks HIV infection of target cells

(2009) H. Tanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

(2009) B. R. O'Keefe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA