Algal Lectins as Potential HIV Microbicide Candidates

Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains

(2012) Geoffrey Férir et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Griffithsin Has Antiviral Activity against Hepatitis C Virus

(2011) Philip Meuleman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Solution Structure of the Monovalent Lectin Microvirin in Complex with Manα(1–2)Man Provides a Basis for Anti-HIV Activity with Low Toxicity

(2011) Syed Shahzad-ul-Hussan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin

(2011) X. Huang et al.   JOURNAL OF GENERAL VIROLOGY

Binding of the Mannose-Specific Lectin, Griffithsin, to HIV-1 gp120 Exposes the CD4-Binding Site

(2011) K. B. Alexandre et al.   JOURNAL OF VIROLOGY

High-Mannose Glycan-Dependent Epitopes Are Frequently Targeted in Broad Neutralizing Antibody Responses during Human Immunodeficiency Virus Type 1 Infection

(2011) C. L. Lavine et al.   JOURNAL OF VIROLOGY

Prevention of vaginal SHIV transmission in macaques by a live recombinant Lactobacillus

(2011) L A Lagenaur et al.   Mucosal Immunology

Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate

(2011) Joseph Calvin Kouokam et al.   PLoS One

Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque

(2011) L. M. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of the Anti-HIV Activity of the Cyanobacterial Oscillatoria Agardhii Agglutinin

(2011) Leonardus M.I. Koharudin et al.   STRUCTURE

Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C

(2011) Geoffrey Férir et al.   VIROLOGY

The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4+ cells

(2011) Kabamba B. Alexandre et al.   VIROLOGY

The antiviral protein cyanovirin-N: the current state of its production and applications

(2010) Sheng Xiong et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Genital secretory immune response to chronic simian immunodeficiency virus (SIV) infection: a comparison between intravenously and genitally inoculated rhesus macaques

(2010) C. J. MILLER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Novel Fold and Carbohydrate Specificity of the Potent Anti-HIV Cyanobacterial Lectin fromOscillatoria agardhii

(2010) Leonardus M. I. Koharudin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microvirin, a Novel α(1,2)-Mannose-specific Lectin Isolated fromMicrocystis aeruginosa, Has Anti-HIV-1 Activity Comparable with That of Cyanovirin-N but a Much Higher Safety Profile

(2010) Dana Huskens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting early infection to prevent HIV-1 mucosal transmission

(2010) Ashley T. Haase   NATURE

Topology of the disulfide bonds in the antiviral lectin scytovirin

(2010) Tinoush Moulaei et al.   PROTEIN SCIENCE

Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women

(2010) Q. Abdool Karim et al.   SCIENCE

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

(2010) Tinoush Moulaei et al.   STRUCTURE

Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin

(2010) Kabamba B. Alexandre et al.   VIROLOGY

HIV-1 infection of human penile explant tissue and protection by candidate microbicides

(2009) Lucia Fischetti et al.   AIDS

Development of topical microbicides to prevent the sexual transmission of HIV

(2009) Robert W. Buckheit et al.   ANTIVIRAL RESEARCH

Multivalent interactions with gp120 are required for the anti-HIV activity of Cyanovirin

(2009) Yinan Liu et al.   BIOPOLYMERS

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

(2009) B. R. O'Keefe et al.   JOURNAL OF VIROLOGY

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

(2009) B. R. O'Keefe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV infection of the genital mucosa in women

(2009) Florian Hladik et al.   Current HIV/AIDS Reports

Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N

(2008) D SMEE et al.   ANTIVIRAL RESEARCH

Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent

(2008) Dana Huskens et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cyanovirin-N potently inhibits human immunodeficiency virus type 1 infection in cellular and cervical explant models

(2008) V. Buffa et al.   JOURNAL OF GENERAL VIROLOGY

Human immunodeficiency virus-1 acquisition in genital mucosa: Langerhans cells as key-players

(2008) M. A. W. P. de Jong et al.   JOURNAL OF INTERNAL MEDICINE

Glycosylation Site-Specific Analysis of HIV Envelope Proteins (JR-FL and CON-S) Reveals Major Differences in Glycosylation Site Occupancy, Glycoform Profiles, and Antigenic Epitopesʼ Accessibility

(2008) Eden P. Go et al.   JOURNAL OF PROTEOME RESEARCH

The Achilles Heel of the Trojan Horse Model of HIV-1 trans-Infection

(2008) Marielle Cavrois et al.   PLoS Pathogens

HIV Traffics through a Specialized, Surface-Accessible Intracellular Compartment during trans-Infection of T Cells by Mature Dendritic Cells

(2008) Hyun Jae Yu et al.   PLoS Pathogens