Inflammatory priming predisposes mice to age-related retinal degeneration

Disease Tolerance as a Defense Strategy

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Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration

(2011) Debarshi Mustafi et al.   FASEB JOURNAL

The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65

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Global cellular changes induced by Legionella pneumophila infection of bone marrow-derived macrophages

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Mucolipin-3 Regulates Luminal Calcium, Acidification, and Membrane Fusion in the Endosomal Pathway

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Mechanism of All-trans-retinal Toxicity with Implications for Stargardt Disease and Age-related Macular Degeneration

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Mouse genomic variation and its effect on phenotypes and gene regulation

(2011) Thomas M. Keane et al.   NATURE

Primary amines protect against retinal degeneration in mouse models of retinopathies

(2011) Akiko Maeda et al.   Nature Chemical Biology

Genetic Variations Strongly Influence Phenotypic Outcome in the Mouse Retina

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Immune regulation in the retina

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Therapeutic targets in age-related macular disease

(2010) Alan C. Bird   JOURNAL OF CLINICAL INVESTIGATION

Understanding mechanisms underlying human gene expression variation with RNA sequencing

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Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs

(2010) Mitchell Guttman et al.   NATURE BIOTECHNOLOGY

Palmitoylation stabilizes unliganded rod opsin

(2010) A. Maeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane-binding and enzymatic properties of RPE65

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Inflammatory networks during cellular senescence: causes and consequences

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Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration

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Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms

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BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Is Overexpressed in Age-related Macular Degeneration

(2009) DanHong Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury

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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Para-inflammation in the aging retina

(2009) Heping Xu et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Live Imaging of Neuronal Degradation by Microglia Reveals a Role for v0-ATPase a1 in Phagosomal Fusion In Vivo

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Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

A HapMap harvest of insights into the genetics of common disease

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Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Oxidative damage–induced inflammation initiates age-related macular degeneration

(2008) Joe G Hollyfield et al.   NATURE MEDICINE

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

How vision begins: An odyssey

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