Role of protein kinase CK2 in antitumor drug resistance

Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia

(2019) Anna Richter et al.   BMC CANCER

Fibroblasts from patients with idiopathic pulmonary fibrosis are resistant to cisplatin-induced cell death via enhanced CK2-dependent XRCC1 activity

(2019) Jintaek Im et al.   APOPTOSIS

Combination therapies with HSP90 inhibitors against colorectal cancer

(2019) Kushtrim Kryeziu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Inhibiting casein kinase 2 overcomes paclitaxel resistance in gastric cancer

(2019) Minkyu Jung et al.   Gastric Cancer

Cancer Stem Cells: Acquisition, Characteristics, Therapeutic Implications, Targeting Strategies and Future Prospects

(2019) Anoop K. Yadav et al.   Stem Cell Reviews and Reports

Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors

(2018) D Westover et al.   ANNALS OF ONCOLOGY

Casein kinase II phosphorylates the C-terminal region of Lif1 to promote the Lif1-Xrs2 interaction needed for non-homologous end joining

(2018) Kenichiro Matsuzaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Advances in studies of tyrosine kinase inhibitors and their acquired resistance

(2018) Qinlian Jiao et al.   Molecular Cancer

The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells

(2018) Ruiting Lin et al.   MOLECULAR CELL

Dependence of HSP27 cellular level on protein kinase CK2 discloses novel therapeutic strategies

(2018) Christian Borgo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibition of casein kinase 2 disrupts differentiation of myeloid cells in cancer and enhances the efficacy of immunotherapy in mice

(2018) Ayumi Hashimoto et al.   CANCER RESEARCH

DNA mismatch repair activity of MutLα is regulated by CK2-dependent phosphorylation of MLH1 (S477)

(2018) Isabel M. Weßbecher et al.   MOLECULAR CARCINOGENESIS

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma

(2018) Teresa Purzner et al.   Science Signaling

Pharmacological Inhibition of Casein Kinase 2 Enhances the Effectiveness of PI3K Inhibition in Colon Cancer Cells

(2018) CRYSTAL SEMAAN et al.   ANTICANCER RESEARCH

Therapeutic strategies involving survivin inhibition in cancer

(2018) David Martínez‐García et al.   MEDICINAL RESEARCH REVIEWS

Preclinical In Vitro and In Vivo Evidence of an Antitumor Effect of CX-4945, a Casein Kinase II Inhibitor, in Cholangiocarcinoma

(2018) Kais Zakharia et al.   Translational Oncology

Protein kinase CK2 is important for the function of glioblastoma brain tumor initiating cells

(2017) Amber L. Rowse et al.   JOURNAL OF NEURO-ONCOLOGY

Hybrid of DNA-targeting Chlorambucil with Pt(IV) Species to Reverse Drug Resistance

(2017) Feihong Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Unravelling the role of protein kinase CK2 in metal toxicity using gene deletion mutants

(2017) Adam J. Johnson et al.   Metallomics

Inhibition of protein kinase CK2 sensitizes non-small cell lung cancer cells to cisplatin via upregulation of PML

(2017) Bo Yang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells

(2017) Susanne Schaefer et al.   PLoS One

CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7 expression

(2017) Chuangzhong Deng et al.   WORLD JOURNAL OF UROLOGY

Corrigendum: Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival

(2017) Youn-Jung Kang et al.   Nature Communications

Association of protein kinase CK2 inhibition with cellular radiosensitivity of non-small cell lung cancer

(2017) Qianwen Li et al.   Scientific Reports

Stem Cell-Like Properties of CK2β-down Regulated Mammary Cells

(2017) Eve Duchemin-Pelletier et al.   Cancers

Phosphoproteomics Reveals HMGA1, a CK2 Substrate, as a Drug-Resistant Target in Non-Small Cell Lung Cancer

(2017) Yi-Ting Wang et al.   Scientific Reports

Generation and quantitative proteomics analysis of CK2α/α’(−/−) cells

(2017) Christian Borgo et al.   Scientific Reports

CK2 modulates adipocyte insulin-signaling and is up-regulated in human obesity

(2017) Christian Borgo et al.   Scientific Reports

Molecular Pathways: Emergence of Protein Kinase CK2 (CSNK2) as a Potential Target to Inhibit Survival and DNA Damage Response and Repair Pathways in Cancer Cells

(2016) A. J. Rabalski et al.   CLINICAL CANCER RESEARCH

Constitutive activation of casein kinase 2 in glioblastomas: Absence of class restriction and broad therapeutic potential

(2016) NADEGE DUBOIS et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15

(2016) Paula Kinsella et al.   INVESTIGATIONAL NEW DRUGS

Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma

(2016) Bingying Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase CK2 regulates AKT, NF-κB and STAT3 activation, stem cell viability and proliferation in acute myeloid leukemia

(2016) L Quotti Tubi et al.   LEUKEMIA

Revelation of molecular basis for chromium toxicity by phenotypes of Saccharomyces cerevisiae gene deletion mutants

(2016) Adam J. Johnson et al.   Metallomics

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer

(2016) Shaokun Shu et al.   NATURE

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling

(2016) Tanvi Shekhar-Guturja et al.   Nature Chemical Biology

Heat Shock Proteins Promote Cancer: It's a Protection Racket

(2016) Stuart K. Calderwood et al.   TRENDS IN BIOCHEMICAL SCIENCES

New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells

(2016) Jörg C. Heinrich et al.   Oncotarget

Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies

(2016) Valentina Salizzato et al.   Oncotarget

BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation

(2015) Alessandro Morotti et al.   CELL CYCLE

Casein kinases as potential therapeutic targets

(2015) Giorgio Cozza et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer

(2015) Yansong Bian et al.   International Journal of Biological Sciences

Casein Kinase 2 (CK2)-mediated Phosphorylation of Hsp90β as a Novel Mechanism of Rifampin-inducedMDR1Expression

(2015) So Won Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The kinase inhibitor D11 induces caspase-mediated cell death in cancer cells resistant to chemotherapeutic treatment

(2015) Barbara Guerra et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Kinases, tails and more: Regulation of PTEN function by phosphorylation

(2015) Rita Fragoso et al.   METHODS

Suppression of casein kinase 2 sensitizes tumor cells to antitumor TRAIL therapy by regulating the phosphorylation and localization of p65 in prostate cancer

(2015) XIAOKUN GANG et al.   ONCOLOGY REPORTS

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16to trigger its nuclear localization

(2015) Lina Herhaus et al.   Science Signaling

Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics

(2015) Chia-Feng Tsai et al.   Nature Communications

Different Persistence of the Cellular Effects Promoted by Protein Kinase CK2 Inhibitors CX-4945 and TDB

(2015) Cristina Girardi et al.   Biomed Research International

Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16to trigger its nuclear localization

(2015) Lina Herhaus et al.   Science Signaling

Antitumoral activity of allosteric inhibitors of Protein kinase CK2

(2015) Virginie Moucadel et al.   Oncotarget

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

(2015) Mehdi Mollapour et al.   Oncotarget

Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential

(2014) Giorgio Cozza et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Converting Potent Indeno[1,2-b]indole Inhibitors of Protein Kinase CK2 into Selective Inhibitors of the Breast Cancer Resistance Protein ABCG2

(2014) Gustavo Jabor Gozzi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphoproteomics of MAPK Inhibition in BRAF-Mutated Cells and a Role for the Lethal Synergism of Dual BRAF and CK2 Inhibition

(2014) R. Parker et al.   MOLECULAR CANCER THERAPEUTICS

Decreased Camptothecin Sensitivity of the Stem-Cell-Like Fraction of Caco2 Cells Correlates with an Altered Phosphorylation Pattern of Topoisomerase I

(2014) Amit Roy et al.   PLoS One

Autophagosome-Mediated EGFR Down-Regulation Induced by the CK2 Inhibitor Enhances the Efficacy of EGFR-TKI on EGFR-Mutant Lung Cancer Cells with Resistance by T790M

(2014) Kwang Sup So et al.   PLoS One

JWA reverses cisplatin resistance via the CK2—XRCC1 pathway in human gastric cancer cells

(2014) W Xu et al.   Cell Death & Disease

CK2 Phosphorylates and Inhibits TAp73 Tumor Suppressor Function to Promote Expression of Cancer Stem Cell Genes and Phenotype in Head and Neck Cancer

(2014) Hai Lu et al.   NEOPLASIA

Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA double-strand break induced by radiomimetic drugs

(2013) Barbara Guerra et al.   CANCER LETTERS

New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

(2013) Eric C. Hales et al.   CELLULAR SIGNALLING

Kinase CK2 Inhibition: An Update

(2013) G. Cozza et al.   CURRENT MEDICINAL CHEMISTRY

Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity

(2013) Laura Quotti Tubi et al.   Journal of Hematology & Oncology

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia

(2013) L R Martins et al.   LEUKEMIA

Aberrant signalling by protein kinase CK2 in imatinib-resistant chronic myeloid leukaemia cells: Biochemical evidence and therapeutic perspectives

(2013) Christian Borgo et al.   Molecular Oncology

Protein Kinase CK2 Inhibition Down Modulates the NF-κB and STAT3 Survival Pathways, Enhances the Cellular Proteotoxic Stress and Synergistically Boosts the Cytotoxic Effect of Bortezomib on Multiple Myeloma and Mantle Cell Lymphoma Cells

(2013) Sabrina Manni et al.   PLoS One

Mechanisms regulating resistance to inhibitors of topoisomerase II

(2013) Ram N. Ganapathi et al.   Frontiers in Pharmacology

Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells

(2012) Joshua Bliesath et al.   CANCER LETTERS

Protein Kinase CK2 Protects Multiple Myeloma Cells from ER Stress-Induced Apoptosis and from the Cytotoxic Effect of HSP90 Inhibition through Regulation of the Unfolded Protein Response

(2012) S. Manni et al.   CLINICAL CANCER RESEARCH

Structural Basis for Dual Nucleotide Selectivity of Aminoglycoside 2″-Phosphotransferase IVa Provides Insight on Determinants of Nucleotide Specificity of Aminoglycoside Kinases

(2012) Kun Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CK2 Inhibitor CX-4945 Suppresses DNA Repair Response Triggered by DNA-Targeted Anticancer Drugs and Augments Efficacy: Mechanistic Rationale for Drug Combination Therapy

(2012) A. Siddiqui-Jain et al.   MOLECULAR CANCER THERAPEUTICS

Plk1 and CK2 Act in Concert to Regulate Rad51 during DNA Double Strand Break Repair

(2012) Keiko Yata et al.   MOLECULAR CELL

Inhibition of CK2α Down-Regulates Hedgehog/Gli Signaling Leading to a Reduction of a Stem-Like Side Population in Human Lung Cancer Cells

(2012) Shulin Zhang et al.   PLoS One

CK2-Mediated Hyperphosphorylation of Topoisomerase I Targets Serine 506, Enhances Topoisomerase I–DNA Binding, and Increases Cellular Camptothecin Sensitivity

(2012) Keya Bandyopadhyay et al.   PLoS One

Effects of the CK2 Inhibitors CX-4945 and CX-5011 on Drug-Resistant Cells

(2012) Sofia Zanin et al.   PLoS One

Quantitative proteomics analysis of BMS-214662 effects on CD34 positive cells from chronic myeloid leukaemia patients

(2012) Stefan Balabanov et al.   PROTEOMICS

Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition

(2012) D Dixit et al.   Cell Death & Disease

Phosphorylation-regulated binding of Ctp1 to Nbs1 is critical for repair of DNA double-strand breaks

(2011) Gerald E. Dodson et al.   CELL CYCLE

Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition

(2011) Alexey Goltsov et al.   CELLULAR SIGNALLING

Induction and activation of the p53 pathway: a role for the protein kinase CK2?

(2011) David W. Meek et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Insulin-like growth factor 1 mediates 5-fluorouracil chemoresistance in esophageal carcinoma cells through increasing survivin stability

(2010) Hsien-Chia Juan et al.   APOPTOSIS

Protein Kinase CK2 Is a Central Regulator of Topoisomerase I Hyperphosphorylation and Camptothecin Sensitivity in Cancer Cell Lines

(2010) Keya Bandyopadhyay et al.   BIOCHEMISTRY

Emergence of protein kinase CK2 as a key target in cancer therapy

(2010) Janeen H. Trembley et al.   BIOFACTORS

Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells

(2010) Jan N Kreutzer et al.   BMC CANCER

Antitumor Activity of Pyridocarbazole and Benzopyridoindole Derivatives that Inhibit Protein Kinase CK2

(2010) R. Prudent et al.   CANCER RESEARCH

CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy

(2010) A. Siddiqui-Jain et al.   CANCER RESEARCH

Proteomic Profile Regulated by the Anticancer Peptide CIGB-300 in Non-Small Cell Lung Cancer (NSCLC) Cells

(2010) Arielis Rodríguez-Ulloa et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells

(2010) B B Olsen et al.   ONCOGENE

Addiction to protein kinase CK2: A common denominator of diverse cancer cells?

(2009) Maria Ruzzene et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Regulation of cell proliferation and survival: Convergence of protein kinases and caspases

(2009) James S. Duncan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Protein Kinase CK2 in Health and Disease

(2009) Y. Miyata   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein Kinase CK2 in Health and Disease

(2009) J. H. Trembley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and  -secretase inhibitors

(2009) A. Silva et al.   HAEMATOLOGICA

Mechanisms of Chemotherapeutic Drug Resistance in Cancer Therapy—A Quick Review

(2009) Fu-Shing Liu   Taiwanese Journal of Obstetrics & Gynecology

Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage

(2008) J Ross Chapman et al.   EMBO REPORTS

Comparative analysis of CK2 expression and function in tumor cell lines displaying sensitivity vs. resistance to chemical induced apoptosis

(2008) Giovanni Di Maira et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

(2008) Nabieh Ayoub et al.   NATURE

Casein kinase I  /  phosphorylates topoisomerase II  at serine-1106 and modulates DNA cleavage activity

(2008) A. G. Grozav et al.   NUCLEIC ACIDS RESEARCH