Inhibition of CK2α Down-Regulates Hedgehog/Gli Signaling Leading to a Reduction of a Stem-Like Side Population in Human Lung Cancer Cells

The Side Population in Human Lung Cancer Cell Line NCI-H460 Is Enriched in Stem-Like Cancer Cells

(2012) Yang Shi et al.   PLoS One

Effects of the Hedgehog pathway inhibitor GDC-0449 on lung cancer cell lines are mediated by side populations

(2011) Fei Tian et al.   CLINICAL AND EXPERIMENTAL MEDICINE

The Dark Side of Protein Kinase CK2 Inhibition

(2011) G. Cozza et al.   CURRENT MEDICINAL CHEMISTRY

CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research

(2011) Silvio E. Perea et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer

(2011) Fabrice Pierre et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma

(2011) R R Singh et al.   ONCOGENE

Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

(2011) Yongbin Chen et al.   PLOS BIOLOGY

Overexpression of Nuclear Protein Kinase CK2 β Subunit and Prognosis in Human Gastric Carcinoma

(2010) Kai-Yuan Lin et al.   ANNALS OF SURGICAL ONCOLOGY

Interaction between CK2α and CK2β, the Subunits of Protein Kinase CK2: Thermodynamic Contributions of Key Residues on the CK2α Surface

(2010) Jennifer Raaf et al.   BIOCHEMISTRY

Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia

(2010) L. R. Martins et al.   BLOOD

Casein Kinase 2 Promotes Hedgehog Signaling by Regulating both Smoothened and Cubitus Interruptus

(2010) Hongge Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer

(2010) Fabrice Pierre et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Functional Polymorphism of the CK2α Intronless Gene Plays Oncogenic Roles in Lung Cancer

(2010) Ming-Szu Hung et al.   PLoS One

Protein Kinase CK2 in Health and Disease

(2009) I. Dominguez et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protein Kinase CK2 in Health and Disease

(2009) J. H. Trembley et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

How druggable is protein kinase CK2?

(2009) Giorgio Cozza et al.   MEDICINAL RESEARCH REVIEWS

Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines

(2009) Shinji Mizuarai et al.   Molecular Cancer

Therapeutic Inhibition of Hedgehog-GLI Signaling in Cancer: Epithelial, Stromal, or Stem Cell Targets?

(2008) Ariel Ruiz i Altaba   CANCER CELL

Impact of protein kinase CK2 on inhibitor of apoptosis proteins in prostate cancer cells

(2008) Guixia Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Protein kinase CK2 as a druggable target

(2008) Stefania Sarno et al.   Molecular BioSystems

Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2

(2007) James S. Duncan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS