Article
Biotechnology & Applied Microbiology
Sachin Kumar Tripathi, Apala Pal, Suchandrima Ghosh, Amit Goel, Rakesh Aggarwal, Soma Banerjee, Saumitra Das
Summary: Chronic hepatitis C virus (HCV) infection is a major cause of end-stage liver diseases, and NEAT1 lncRNA has been found to be highly expressed in liver cancer patients. The study also revealed a correlation between NEAT1 levels and HCV infection, as well as the involvement of NEAT1 in HCC progression through the NEAT1-miR-9-BGH3 axis.
JOURNAL OF GENERAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shouzhen Chen, Yong Wang, Lipeng Chen, Yangyang Xia, Jianfeng Cui, Wenfu Wang, Xuewen Jiang, Jian Wang, Yaofeng Zhu, Shuna Sun, Yongxin Zou, Yaoqin Gong, Benkang Shi
Summary: CUL4B is overexpressed in renal cell carcinoma and promotes tumor progression by activating the c-Met signaling pathway. Targeting CUL4B or c-Met may have therapeutic implications for RCC patients.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Qiuxia Li, Quanjiang Zhang
Summary: MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene expression by binding to the mRNAs of protein-coding genes. In endothelial cells, miR-34a is an early identified miRNA that plays important roles in regulating endothelial functions, angiogenesis, differentiation, senescence, inflammatory response, responses to shear stress, and mitochondrial function. This review provides an overview of the current understanding of miR-34a in endothelial biology and discusses its potential as a therapeutic target for vascular diseases.
Article
Biochemistry & Molecular Biology
Qunsheng Yan, Qingqing Hu, Guoxiang Li, Qiao Qi, Ziyan Song, Jie Shu, Hu Liang, Haoran Liu, Zongyao Hao
Summary: This study found that the lncRNA NEAT1 enhances IRF1 signaling through targeted repression of miR-130a-3p and activates the TLR4/NF-kappa B pathways, promoting oxidative damage during CaOx crystal deposition. This provides an explanation for tubular epithelial damage caused by CaOx crystals and offers new ideas and drug targets for the prevention and treatment of CaOx nephrocalcinosis.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Oncology
Xiuli Dou, Yuxiao Ma, Yijie Qin, Qinglin Dong, Shouwei Zhang, Rui Tian, Mingyu Pan
Summary: NEAT1 regulates cell proliferation and migration in the pathogenesis of PAH by targeting miR-34a-5p that affects KLF4 expression levels. High levels of NEAT1 and KLF4 expression and low miR-34a-5p expression were observed in hypoxia-treated PASMCs and serum from PAH patients, indicating a potential therapeutic target and diagnostic biomarker for PAH.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Jose Maria Zamora-Fuentes, Enrique Hernandez-Lemus, Jesus Espinal-Enriquez
Summary: In this study, a miR-gene co-expression network analysis was conducted to explore the progression of ccRC. The results revealed that miR-217 has different expression patterns in different stages and its target genes play significant roles in cancer progression, providing a new approach for identifying stage-dependent therapeutic targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Qi Lv, Gangmin Wang, Yinan Zhang, Aijun Shen, Junjun Tang, Yi Sun, Chunhui Ma, Peijun Wang
Summary: This study reveals that circAGAP1 is significantly upregulated in ccRCC tissues and is closely associated with tumor size, nuclear grade, and clinical stage. Mechanistic studies demonstrate that cytoplasmic circAGAP1 functions as a ceRNA by sponging miR-15-5p, thereby promoting E2F3 expression. Targeting circAGAP1 may offer a new therapeutic strategy for ccRCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiang Li, Shouwei Zhao, Yu Fu, Ping Zhang, Zhenxing Zhang, Jie Cheng, Laikui Liu, Hongbing Jiang
Summary: The study demonstrates that downregulation of miR-34a-5p is associated with the progression of HNSCC tumors and cells. Functionally, miR-34a-5p inhibits proliferation, migratory/invasive activity, and epithelial-mesenchymal transition in HNSCC cells. Mechanistically, miR-34a-5p suppresses FLOT-2 expression and activates the MEK/ERK1/2 pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Zhenhua Sun, Bingjie Xia, Ming Zhang, Shuai Xu, Yingqian Ma, Xianbo Zhang
Summary: In this case report, a GSSCC patient with MET mutation responded promptly and positively to crizotinib. This provides a new reference for understanding MET abnormalities in GSSCC and offers a new idea for the targeted treatment of gingival carcinoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shivani Bailey, Marta Ferraresso, Luz Alonso-Crisostomo, Dawn Ward, Stephen Smith, James C. Nicholson, Harpreet Saini, Anton J. Enright, Cinzia G. Scarpini, Nicholas Coleman, Matthew J. Murray
Summary: This study identifies the functional significance of miR-371, miR-373, and miR-302/367 in malignant GCTs. These microRNAs inhibit growth through cell cycle disruption.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Chao Yuan, Zhenhong Su, Shengjie Liao, Duanzhuo Li, Zhiwen Zhou, Yawen Wang, Mingchun Quan, Lingling Zeng, Cai Lv, Chenyi Shen, Weida Gong, Jianfeng Wu, Xiaogang Chen, Wenbing Hu, Xu Lv, Wenxia Si, Xin Yu
Summary: Our study reveals that in RCC tissues, the expression levels of BIRC5 and miR-198 are respectively higher and lower compared to normal adjacent tissues. miR-198 suppresses RCC progression by targeting BIRC5, inhibiting cell migration and invasion, promoting cell apoptosis, and inhibiting tumor growth in a xenograft nude mouse model.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Sijing Li, Xiaohui Wei, Jinyong He, Quanquan Cao, Danyu Du, Xiaoman Zhan, Yuqi Zeng, Shengtao Yuan, Li Sun
Summary: miR-34 plays crucial roles in cancer, with its downstream targets involved in multiple signaling pathways and crucial biological processes. Among them, miR-34a is especially important and can effectively suppress tumor progression by combining with chemotherapy or radiotherapy.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Cell Biology
Jieqing Chen, Xinhui Liao, Jianli Cheng, Ganglin Su, Fen Yuan, Zhongfu Zhang, Jianting Wu, Hongbing Mei, Wanlong Tan
Summary: In this study, researchers found that the expression of LncRNA NEAT1 and m6A methylation levels were decreased in RCC tissues, which was associated with poor prognosis for patients. By using CRIPSR/dCas13b-METTL3, they demonstrated that methylating LncRNA NEAT1 in RCC cells led to increased expression levels and reduced proliferation and migration abilities. Moreover, hypermethylation of LncRNA NEAT1 was found to affect the transcriptome in RCC cells, showing potential involvement in key signaling pathways related to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jing Li, Guishan Tan, Yabo Cai, Ruihuan Liu, Xiaolin Xiong, Baohua Gu, Wei He, Bing Liu, Qingyun Ren, Jianping Wu, Bo Chi, Hang Zhang, Yanzhong Zhao, Yangrui Xu, Zhenxing Zou, Fenghua Kang, Kangping Xu
Summary: Compound 15e shows potential as a treatment for renal cell carcinoma by inhibiting MET activation and overcoming drug resistance.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Bin Zhao, Cong Huang, Jie Pan, Hao Hu, Xiaojuan Liu, Kaoyuan Zhang, Fenli Zhou, Xin Shi, Jun Wu, Bo Yu, Xiaofan Chen, Wei Zhang
Summary: Recent evidence shows that circRNAs, particularly circPLIN2, play important regulatory roles in the development and progression of clear cell renal cell carcinoma (ccRCC) by increasing mRNA stability and competitively binding specific miRNA.
CELL DEATH & DISEASE
(2022)
