Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces

Functional significance of the platelet immune receptors GPVI and CLEC-2

(2019) Julie Rayes et al.   JOURNAL OF CLINICAL INVESTIGATION

Immobilized fibrinogen activates human platelets through glycoprotein VI

(2018) Pierre H Mangin et al.   HAEMATOLOGICA

Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation

(2018) I. Induruwa et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Immobilized fibrinogen activates human platelets through glycoprotein VI

(2018) Pierre H Mangin et al.   HAEMATOLOGICA

Anti-adult T‑cell leukemia/lymphoma activity of cerdulatinib, a dual SYK/JAK kinase inhibitor

(2018) Chie Ishikawa et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding

(2018) Constance C. F. M. J. Baaten et al.   BLOOD

High-throughput elucidation of thrombus formation reveals sources of platelet function variability

(2018) Johanna P. van Geffen et al.   HAEMATOLOGICA

Platelet biology and functions: new concepts and clinical perspectives

(2018) Paola E. J. van der Meijden et al.   Nature Reviews Cardiology

Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling

(2017) Rachit Badolia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

(2017) N. S. Poulter et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation

(2015) E. Mammadova-Bach et al.   BLOOD

Syk and Src Family Kinases Regulate C-type Lectin Receptor 2 (CLEC-2)-mediated Clustering of Podoplanin and Platelet Adhesion to Lymphatic Endothelial Cells

(2014) Alice Y. Pollitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of platelet function defects by multi-parameter assessment of thrombus formation

(2014) Susanne M. de Witt et al.   Nature Communications

New Fundamentals in Hemostasis

(2013) Henri H. Versteeg et al.   PHYSIOLOGICAL REVIEWS

Distinct Role of von Willebrand Factor Triplet Bands in Glycoprotein Ib-Dependent Platelet Adhesion and Thrombus Formation under Flow

(2013) Birte Fuchs et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Key role of integrin αIIbβ3 signaling to Syk kinase in tissue factor-induced thrombin generation

(2012) Paola E. J. van der Meijden et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood

(2012) Stephanie M. Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical role for Syk in responses to vascular injury

(2011) P. Andre et al.   BLOOD

Collagen surfaces to measure thrombus formation under flow: possibilities for standardization

(2011) J. W. M. HEEMSKERK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model

(2010) M. P. Reilly et al.   BLOOD

Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood

(2010) N. Pugh et al.   BLOOD

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen

(2010) Karen Gilio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPVI and CLEC-2 in hemostasis and vascular integrity

(2010) S. P. WATSON et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural Insights into the Interactions between Platelet Receptors and Fibrillar Collagen

(2009) Andrew B. Herr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel interactions in platelet biology: CLEC-2/podoplanin and laminin/GPVI

(2009) Y. OZAKI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Cell–collagen interactions: the use of peptide Toolkits to investigate collagen–receptor interactions

(2008) Richard W. Farndale et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Collagen-mimetic peptides mediate flow-dependent thrombus formation by high- or low-affinity binding of integrin α2β1 and glycoprotein VI

(2008) I. C. A. MUNNIX et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Collagen-type specificity of glycoprotein VI as a determinant of platelet adhesion

(2008) Stephanie M. Jung et al.   PLATELETS