Proteomic signatures of neuroinflammation in Alzheimer’s disease, multiple sclerosis and ischemic stroke

Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters

(2018) Marco Del Giudice et al.   BRAIN BEHAVIOR AND IMMUNITY

Cognitive impairment in early stages of multiple sclerosis is associated with high cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain

(2018) E. Quintana et al.   EUROPEAN JOURNAL OF NEUROLOGY

Characterizing disease-associated changes in post-translational modifications by mass spectrometry

(2018) Camilla Thygesen et al.   Expert Review of Proteomics

Immune responses in stroke: how the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures?

(2018) Aditya Rayasam et al.   IMMUNOLOGY

Transformative Opportunities for Single-Cell Proteomics

(2018) Harrison Specht et al.   JOURNAL OF PROTEOME RESEARCH

How many human proteoforms are there?

(2018) Ruedi Aebersold et al.   Nature Chemical Biology

Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes

(2018) Magnus Spangsberg Boesen et al.   Multiple Sclerosis and Related Disorders

Increased AβPP Processing in Familial Danish Dementia Patients

(2018) Shuji Matsuda et al.   JOURNAL OF ALZHEIMERS DISEASE

Post-stroke inflammation—target or tool for therapy?

(2018) Kate Lykke Lambertsen et al.   ACTA NEUROPATHOLOGICA

Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer’s Disease

(2018) Camilla Thygesen et al.   Frontiers in Cellular Neuroscience

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Revisiting biomarker discovery by plasma proteomics

(2017) Philipp E Geyer et al.   Molecular Systems Biology

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

A Primer on Concepts and Applications of Proteomics in Neuroscience

(2017) Fabian Hosp et al.   NEURON

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination

(2017) Yiting Liu et al.   Acta Neuropathologica Communications

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke

(2016) Bettina Hjelm Clausen et al.   ACTA NEUROPATHOLOGICA

Vascular, glial, and lymphatic immune gateways of the central nervous system

(2016) Britta Engelhardt et al.   ACTA NEUROPATHOLOGICA

An updated histological classification system for multiple sclerosis lesions

(2016) Tanja Kuhlmann et al.   ACTA NEUROPATHOLOGICA

Annexin A1 restores Aβ1-42-induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway

(2016) Jong-Chan Park et al.   AGING CELL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Complement is activated in progressive multiple sclerosis cortical grey matter lesions

(2016) Lewis M. Watkins et al.   Journal of Neuroinflammation

The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide

(2016) Miriam Ries et al.   Journal of Neuroinflammation

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Identification of Maturation-Specific Proteins by Single-Cell Proteomics of Human Oocytes

(2016) Irma Virant-Klun et al.   MOLECULAR & CELLULAR PROTEOMICS

Alpha-2 macroglobulin in Alzheimer’s disease: a marker of neuronal injury through the RCAN1 pathway

(2016) V R Varma et al.   MOLECULAR PSYCHIATRY

Inflammation and Stroke: An Overview

(2016) Josef Anrather et al.   Neurotherapeutics

Plasma Proteome Profiling to Assess Human Health and Disease

(2016) Philipp E. Geyer et al.   Cell Systems

Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice

(2015) Alicia A. Babcock et al.   BRAIN BEHAVIOR AND IMMUNITY

Systemic inflammation as a therapeutic target in acute ischemic stroke

(2015) Tomasz Dziedzic   Expert Review of Neurotherapeutics

Myelin-specific T cells induce interleukin-1beta expression in lesion-reactive microglial-like cells in zones of axonal degeneration

(2015) Manuela Grebing et al.   GLIA

A comprehensive map and functional annotation of the normal human cerebrospinal fluid proteome

(2015) Yang Zhang et al.   Journal of Proteomics

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Systemic inflammation as a therapeutic target in acute ischemic stroke

(2015) Tomasz Dziedzic   Expert Review of Neurotherapeutics

Influence of Alpha-2-Macroglobulin 5 bp I/D and Ile1000Val Polymorphisms on the Susceptibility of Alzheimer’s disease: A Systematic Review and Meta-analysis of 52 Studies

(2014) Hui Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Beta2-Microglobulin as a Diagnostic Marker in Cerebrospinal Fluid: A Follow-Up Study

(2014) Jana Svatoňová et al.   DISEASE MARKERS

α 1-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity

(2014) Maike Gold et al.   Journal of Neuroinflammation

Chemokines and Chemokine Receptors in Multiple Sclerosis

(2014) Wenjing Cheng et al.   MEDIATORS OF INFLAMMATION

In-depth Characterization of the Cerebrospinal Fluid (CSF) Proteome Displayed Through the CSF Proteome Resource (CSF-PR)

(2014) Astrid Guldbrandsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Complement activation in multiple sclerosis plaques: an immunohistochemical analysis

(2014) Gillian Ingram et al.   Acta Neuropathologica Communications

Microglial Phenotype and Adaptation

(2013) B. J. L. Eggen et al.   Journal of Neuroimmune Pharmacology

The Impact of Biosampling Procedures on Molecular Data Interpretation

(2013) Karl Sköld et al.   MOLECULAR & CELLULAR PROTEOMICS

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Clinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome

(2013) Benjamin Lam et al.   Alzheimers Research & Therapy

Alpha-2-macroglobulin: A physiological guardian

(2012) Ahmed A. Rehman et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Sample size and statistical power considerations in high-dimensionality data settings: a comparative study of classification algorithms

(2010) Yu Guo et al.   BMC BIOINFORMATICS

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Recent cerebrospinal fluid biomarker studies of Alzheimer’s disease

(2010) Yong Seok Choi et al.   Expert Review of Proteomics

Annexin A1: A Central Player in the Anti-Inflammatory and Neuroprotective Role of Microglia

(2010) S. McArthur et al.   JOURNAL OF IMMUNOLOGY

Mass spectrometry in high-throughput proteomics: ready for the big time

(2010) Tommy Nilsson et al.   NATURE METHODS

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Enhanced Microglial Clearance of Myelin Debris in T Cell-Infiltrated Central Nervous System

(2009) Helle Hvilsted Nielsen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2009) David Moher et al.   PLOS MEDICINE