Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease
Published 2016 View Full Article
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Title
Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease
Authors
Keywords
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Journal
Frontiers in Neuroscience
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2016-05-25
DOI
10.3389/fnins.2016.00205
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Note: Only part of the references are listed.- Increased Protein and Lipid Oxidative Damage in Mitochondria Isolated from Lymphocytes from Patients with Alzheimer's Disease: Insights into the Role of Oxidative Stress in Alzheimer's Disease and Initial Investigations into a Potential Biomarker for this Dementing Disorder
- (2018) Rukhsana Sultana et al. JOURNAL OF ALZHEIMERS DISEASE
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- (2016) Eugenio Barone Current Alzheimer Research
- Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation
- (2016) Ming-Yu Wu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Monoamine oxidase A (MAOA) genotype predicts greater aggression through impulsive reactivity to negative affect
- (2015) David S. Chester et al. BEHAVIOURAL BRAIN RESEARCH
- Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
- (2015) Celeste M. Karch et al. BIOLOGICAL PSYCHIATRY
- Multi-target iron-chelators improve memory loss in a rat model of sporadic Alzheimer's disease
- (2015) Melita Salkovic-Petrisic et al. LIFE SCIENCES
- Immune attack: the role of inflammation in Alzheimer disease
- (2015) Frank L. Heppner et al. NATURE REVIEWS NEUROSCIENCE
- The monoaminergic footprint of depression and psychosis in dementia with Lewy bodies compared to Alzheimer’s disease
- (2015) Yannick Vermeiren et al. Alzheimers Research & Therapy
- Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease
- (2014) Gerard Esteban et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- The Novel Multi-Target Iron Chelator, M30 Modulates HIF-1α-Related Glycolytic Genes and Insulin Signaling Pathway in the Frontal Cortex of APP/PS1 Alzheimer’s Disease Mice
- (2014) Danit Mechlovich et al. Current Alzheimer Research
- Dietary Polyphenols for Treatment of Alzheimer’s Disease– Future Research and Development
- (2014) D. Malar et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Effects of Novel Monoamine Oxidases and Cholinesterases Targeting Compounds on Brain Neurotransmitters and Behavior in Rat Model of Vascular Dementia
- (2014) Anna Stasiak et al. CURRENT PHARMACEUTICAL DESIGN
- Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease
- (2014) Li Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil–indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease
- (2014) Oscar M. Bautista-Aguilera et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- 8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation
- (2014) Luiza M.F. Gomes et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches
- (2014) Inelia Morales et al. Frontiers in Cellular Neuroscience
- Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer’s disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids
- (2014) José Marco-Contelles et al. Drug Design Development and Therapy
- 2013 Alzheimer's disease facts and figures
- (2013) Alzheimers & Dementia
- Exploring the structural basis of the selective inhibition of monoamine oxidase A by dicarbonitrile aminoheterocycles: Role of Asn181 and Ile335 validated by spectroscopic and computational studies
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- Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?
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- Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers
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- (2012) Douglas R. Galasko et al. ARCHIVES OF NEUROLOGY
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- (2010) David J. Bonda et al. DRUGS & AGING
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- (2010) Peng Lei et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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- (2010) Karla M. Acevedo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2010) P. A. Adlard et al. JOURNAL OF NEUROSCIENCE
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- (2010) Daniel P. Perl MOUNT SINAI JOURNAL OF MEDICINE
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- (2009) Mitsugu Fukuda et al. BIOMEDICAL RESEARCH-TOKYO
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- (2009) Chiara A. Damante et al. INORGANIC CHEMISTRY
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- (2009) Zhong-Ying Mo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2009) Mark D. Meadowcroft et al. JOURNAL OF MAGNETIC RESONANCE IMAGING
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- (2009) Peter J. Crouch et al. JOURNAL OF NEUROCHEMISTRY
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- (2009) Xinglong Wang et al. JOURNAL OF NEUROCHEMISTRY
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- (2009) L. Besser et al. JOURNAL OF NEUROSCIENCE
- PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] confers MAO-B independent neuroprotection in ER stress-induced cell death
- (2009) Elisenda Sanz et al. MOLECULAR AND CELLULAR NEUROSCIENCE
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- (2008) Alain Boom et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
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- (2008) M. S. Song et al. EUROPEAN JOURNAL OF NEUROSCIENCE
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