Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

Ultrasonic accelerated Knoevenagel condensation by magnetically recoverable MgFe 2 O 4 nanocatalyst: A rapid and green synthesis of coumarins under solvent-free conditions

(2018) Javad Safaei Ghomi et al.   ULTRASONICS SONOCHEMISTRY

Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease

(2017) Jacques Joubert et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel coumarin- N -benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease

(2017) Jin-Shuai Lan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors

(2017) María Carmen Costas-Lago et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A rational approach to elucidate human monoamine oxidase molecular selectivity

(2017) Giuseppe Felice Mangiatordi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Coumarin derivatives: an updated patent review (2015-2016)

(2017) Anastasia Detsi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Understanding the Molecular Determinant of Reversible Human Monoamine Oxidase B Inhibitors Containing 2H-Chromen-2-One Core: Structure-Based and Ligand-Based Derived Three-Dimensional Quantitative Structure–Activity Relationships Predictive Models

(2017) Milan Mladenović et al.   Journal of Chemical Information and Modeling

Computational Multitarget Drug Design

(2017) Weilin Zhang et al.   Journal of Chemical Information and Modeling

Structures of antimutagenic constituents in the peels of Citrus limon

(2017) Takahiro Matsumoto et al.   Journal of Natural Medicines

Sonochemistry as a General Procedure for the Synthesis of Coumarins­, Including Multigram Synthesis

(2017) Marcus de Souza et al.   SYNTHESIS-STUTTGART

Fungi as a source of natural coumarins production

(2016) Tania Maria Costa et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Design, synthesis and biological evaluation of novel donepezil–coumarin hybrids as multi-target agents for the treatment of Alzheimer’s disease

(2016) Sai-Sai Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Coumarins as cholinesterase inhibitors: A review

(2016) Luana G. de Souza et al.   CHEMICO-BIOLOGICAL INTERACTIONS

An investigation into the synthesis of azido-functionalised coumarins for application in 1,3-dipolar “click” cycloaddition reactions

(2016) Vikki Evans et al.   DYES AND PIGMENTS

Therapeutic potential of coumarins as antiviral agents

(2016) Mohd. Zaheen Hassan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

3-Trifluoromethylated Coumarins and Carbostyrils by Radical Trifluoromethylation ofortho-Functionalized Cinnamic Esters

(2016) Slim Chaabouni et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Relationship between coumarin-induced hepatocellular toxicity and mitochondrial function in rats

(2016) Yasuhiro Tanaka et al.   FOOD AND CHEMICAL TOXICOLOGY

Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules

(2016) Slavka Hamulakova et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents

(2016) Leonardo Pisani et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Regioselective Metal-Free Construction of 3-Aroyl Coumarins by Csp2-H Functionalization

(2016) Farnaz Jafarpour et al.   JOURNAL OF ORGANIC CHEMISTRY

SnCl4 grafted on silica gel: an efficient catalyst for solvent-free synthesis of coumarins via the Pechmann condensation

(2016) Rui Sun et al.   Journal of the Iranian Chemical Society

Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif

(2016) Leonardo Pisani et al.   MOLECULES

Natural and Synthetic Coumarins with Effects on Inflammation

(2016) Gilbert Kirsch et al.   MOLECULES

A green and convenient approach for the one-pot solvent-free synthesis of coumarins and β-amino carbonyl compounds using Lewis acid grafted sulfonated carbon@titania composite

(2016) Manmeet Kour et al.   MONATSHEFTE FUR CHEMIE

Visible-Light-Promoted Dual C–C Bond Formations of Alkynoates via a Domino Radical Addition/Cyclization Reaction: A Synthesis of Coumarins

(2016) Shangbiao Feng et al.   ORGANIC LETTERS

Antioxidant Activities of 4-Methylumbelliferone Derivatives

(2016) Yasameen K. Al-Majedy et al.   PLoS One

Recent Advances in Transition-Metal-Catalyzed Synthesis of Coumarins

(2016) Diksha Katiyar et al.   SYNTHESIS-STUTTGART

8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease

(2016) José L. Domínguez et al.   ChemistrySelect

A cost-effective and green aqueous synthesis of 3-substituted coumarins catalyzed by potassium phthalimide

(2015) H. Kiyani et al.   BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA

3-Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases

(2015) Maria João Matos et al.   ChemMedChem

Cardiovascular Effects of Coumarins Besides their Antioxidant Activity

(2015) Iveta Najmanova et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease

(2015) Sai-Sai Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase

(2015) Angela Stefanachi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent progress in the drug development of coumarin derivatives as potent antituberculosis agents

(2015) Rangappa S. Keri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

(2015) Anuradha Thakur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Investigation of (E)-3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

(2015) Sébastien L. Degorce et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases

(2015) Roberta Farina et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microwave-Assisted Copper-Catalyzed Four-Component Tandem Synthesis of 3-N-Sulfonylamidine Coumarins

(2015) Govindarasu Murugavel et al.   JOURNAL OF ORGANIC CHEMISTRY

Silver-Mediated Radical Cyclization of Alkynoates and α-Keto Acids Leading to Coumarins via Cascade Double C–C Bond Formation

(2015) Kelu Yan et al.   JOURNAL OF ORGANIC CHEMISTRY

Visible-Light-Mediated Radical Aryldifluoroacetylation of Alkynes with Ethyl Bromodifluoroacetate for the Synthesis of 3-Difluoroacetylated Coumarins

(2015) Weijun Fu et al.   JOURNAL OF ORGANIC CHEMISTRY

Solvent-free one-pot synthesis of coumarins using molybdate sulfuric acid as highly efficient catalyst

(2015) Leila Moradi et al.   Journal of the Iranian Chemical Society

Recent advances and therapeutic journey of coumarins: current status and perspectives

(2015) Kuldipsinh P. Barot et al.   MEDICINAL CHEMISTRY RESEARCH

Rational Design of Coumarin Derivatives as CK2 Inhibitors by Improving the Interaction with the Hinge Region

(2015) Na Zhang et al.   Molecular Informatics

Synthesis of substituted coumarins catalyzed by sawdust-SO3H. An efficient and environmentally benign solid acid catalyst under solvent-free conditions

(2015) E. Tahanpesar et al.   RUSSIAN JOURNAL OF GENERAL CHEMISTRY

π-Expanded coumarins: synthesis, optical properties and applications

(2015) Mariusz Tasior et al.   Journal of Materials Chemistry C

Syntheses of coumarin–tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase

(2014) Qi Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Coumarin hybrids as novel therapeutic agents

(2014) Sonali Sandhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Heme Enzyme Structure and Function

(2014) Thomas L. Poulos   CHEMICAL REVIEWS

Insight into the Functional and Structural Properties of 3-Arylcoumarin as an Interesting Scaffold in Monoamine Oxidase B Inhibition

(2014) Maria João Matos et al.   ChemMedChem

Monoamine Oxidase (MAO) Inhibitory Activity: 3-Phenylcoumarins versus 4-Hydroxy-3-phenylcoumarins

(2014) Giovanna L. Delogu et al.   ChemMedChem

Multifunctional compounds: Smart molecules for multifactorial diseases

(2014) Yogita Bansal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Novel Tacrine Derivatives and Tacrine–Coumarin Hybrids as Cholinesterase Inhibitors

(2014) Slavka Hamulakova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toward the First Class of Suicide Inhibitors of Kallikreins Involved in Skin Diseases

(2014) Xiao Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two-year, randomized, controlled study of safinamide as add-on to levodopa in mid to late Parkinson's disease

(2014) Rupam Borgohain et al.   MOVEMENT DISORDERS

Molybdate sulfuric acid-catalyzed one-pot synthesis of substituted coumarins under solvent-free conditions

(2014) Saeed Khodabakhshi et al.   RESEARCH ON CHEMICAL INTERMEDIATES

A solvent-free synthesis of coumarins using 1,3-disulfonic acid imidazolium hydrogen sulfate as a reusable and effective ionic liquid catalyst

(2014) Farhad Shirini et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Recent Advances in the Synthesis of Coumarin Derivatives via Knoevenagel Condensation: A Review

(2014) Rajesh H. Vekariya et al.   SYNTHETIC COMMUNICATIONS

Synthesis of α-bromocarbonyl compounds: recent advances

(2014) Rajesh H. Vekariya et al.   TETRAHEDRON

Design and synthesis of ERα/ERβ selective coumarin and chromene derivatives as potential anti-breast cancer and anti-osteoporotic agents

(2014) M. Kamil Hussain et al.   RSC Advances

A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer’s disease

(2013) Pravin O. Patil et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and anti-tumor activities of novel triphenylethylene–coumarin hybrids, and their interactions with Ct-DNA

(2013) Hua Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Antithrombotic Activity of a Newly Synthesized Coumarin Derivative 3-(5-Hydroxy-2,2-dimethyl-chroman-6-yl)-N-{2-[3-(5-hydroxy-2,2-dimethyl-chroman-6-yl)-propionylamino]-ethyl}-propionamide

(2013) Manish Jain et al.   Chemical Biology & Drug Design

Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: Synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study

(2013) Maria J. Matos et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors

(2013) Ali Asadipour et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fine molecular tuning at position 4 of 2H-chromen-2-one derivatives in the search of potent and selective monoamine oxidase B inhibitors

(2013) Leonardo Pisani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel tacrine–coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease

(2013) Sai-Sai Xie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Computational methods for the design of potent aromatase inhibitors

(2013) Angelo Danilo Favia et al.   Expert Opinion on Drug Discovery

Discovery, Biological Evaluation, and Structure–Activity and −Selectivity Relationships of 6′-Substituted (E)-2-(Benzofuran-3(2H)-ylidene)-N-methylacetamides, a Novel Class of Potent and Selective Monoamine Oxidase Inhibitors

(2013) Leonardo Pisani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combinatorial biosynthesis of plant-specific coumarins in bacteria

(2013) Yuheng Lin et al.   METABOLIC ENGINEERING

Human cytochromes P450 in health and disease

(2013) D. W. Nebert et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Novel coumarin derivatives bearing N-benzyl pyridinium moiety: Potent and dual binding site acetylcholinesterase inhibitors

(2012) Masoumeh Alipour et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase

(2012) Marco Catto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Natural product coumarins that inhibit human carbonic anhydrases

(2012) Rohan A. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neoflavonoids and Tetrahydroquinolones as Possible Cancer Chemopreventive Agents

(2012) Suaib Luqman et al.   Chemical Biology & Drug Design

Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases

(2012) L. Pisani et al.   CURRENT MEDICINAL CHEMISTRY

Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders

(2012) Werner J Geldenhuys et al.   Expert Opinion on Drug Discovery

Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents

(2011) Oh Song Kwon et al.   ARCHIVES OF PHARMACAL RESEARCH

Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells

(2011) Nathaniel Edward Bennett Saidu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease

(2011) Preet Anand et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives

(2011) Daniela Secci et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Strategies of multi-objective optimization in drug discovery and development

(2011) Orazio Nicolotti et al.   Expert Opinion on Drug Discovery

Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Aromatase Inhibitors Selective over 17-α-Hydroxylase/C17−20 Lyase

(2011) Angela Stefanachi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Study of a Series of 3-Arylcoumarins as Potent and Selective Monoamine Oxidase B Inhibitors

(2011) Maria J. Matos et al.   JOURNAL OF MEDICINAL CHEMISTRY

In silico identification of viper phospholipaseA2 inhibitors: validation by in vitro, in vivo studies

(2011) Amit Nargotra et al.   JOURNAL OF MOLECULAR MODELING

Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations

(2011) Benoît Sanson et al.   PROTEIN SCIENCE

Developmental effects of coumarin and the anticoagulant coumarin derivative warfarin on zebrafish (Danio rerio) embryos

(2011) Stefan Weigt et al.   REPRODUCTIVE TOXICOLOGY

Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives

(2010) Omaima M. Abdelhafez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases

(2010) Sergio Valente et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and in vitro evaluation of novel coumarin–chalcone hybrids as potential anticancer agents

(2010) Koneni V. Sashidhara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors

(2010) Leonardo Pisani et al.   ChemMedChem

MAO inhibitors: Risks, benefits, and lore

(2010) M. WIMBISCUS et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Fulvestrant - A Novel Endocrine Therapy for Breast Cancer

(2010) S. Johnston et al.   CURRENT MEDICINAL CHEMISTRY

First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases

(2010) Ulrike E. Hille et al.   ACS Medicinal Chemistry Letters

Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer

(2009) Koichiro Harada et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Biological Evaluation of New Geiparvarin Derivatives

(2009) Stefano Chimichi et al.   ChemMedChem

Structure−Activity Relationship of New Anti-Hepatitis C Virus Agents: Heterobicycle−Coumarin Conjugates

(2009) Johan Neyts et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Molecular Modeling, and Selective Inhibitory Activity against Human Monoamine Oxidases of 3-Carboxamido-7-Substituted Coumarins†

(2009) Franco Chimenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Novel Class of Potent Coumarin Monoamine Oxidase B Inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one Methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible, and Orally Active Monoamine Oxidase B Inhibitor

(2009) Leonardo Pisani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toxicology and risk assessment of coumarin: Focus on human data

(2009) Klaus Abraham et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Phenylpropanoid Biosynthesis

(2009) Thomas Vogt   Molecular Plant

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors

(2008) Francesco Leonetti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of polymethoxylated 4-heteroarylcoumarins as tubulin assembly inhibitor

(2008) Olga G. Ganina et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Quantitative Structure−Activity Relationship and Complex Network Approach to Monoamine Oxidase A and B Inhibitors

(2008) Lourdes Santana et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multifunctional neuroprotective derivatives of rasagiline as anti-alzheimer’s disease drugs

(2008) Orly Weinreb et al.   Neurotherapeutics

Scopoletin is biosynthesized viaortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase inArabidopsis thaliana

(2008) Kosuke Kai et al.   PLANT JOURNAL

Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds

(2007) Lorna Piazzi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS