Collagen cross-linking mediated by lysyl hydroxylase 2: an enzymatic battlefield to combat fibrosis

HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

(2019) Steve Stegen et al.   NATURE

SiMPLOD, a structure‐integrated database of collagen lysyl hydroxylase (LH/PLOD) enzyme variants

(2019) Luigi Scietti et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Analyses of lysine aldehyde cross-linking in collagen reveal that the mature cross-link histidinohydroxylysinonorleucine is an artifact

(2019) David R. Eyre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Matrix Cross-Linking Enhances Fibroblast Growth and Protects against Matrix Proteolysis in Lung Fibrosis

(2018) Christopher J. Philp et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The fibrotic tumor stroma

(2018) Mitsuo Yamauchi et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular and tissue alterations of collagens in fibrosis

(2018) Sylvie Ricard-Blum et al.   MATRIX BIOLOGY

Liver fibrosis: Direct antifibrotic agents and targeted therapies

(2018) Detlef Schuppan et al.   MATRIX BIOLOGY

Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor

(2018) Zhuo Wang et al.   Cell Death & Disease

Isozyme-specific comprehensive characterization of transglutaminase-crosslinked substrates in kidney fibrosis

(2018) Hideki Tatsukawa et al.   Scientific Reports

Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3

(2018) Luigi Scietti et al.   Nature Communications

Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal

(2017) Naoki Ikenaga et al.   GUT

Inhibition of FKBP10 Attenuates Hypertrophic Scarring through Suppressing Fibroblast Activity and Extracellular Matrix Deposition

(2017) Xiao Liang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Role of the Lysyl Oxidases in Tissue Repair and Remodeling: A Concise Review

(2017) Linyi Cai et al.   Tissue Engineering and Regenerative Medicine

Overhydroxylation of Lysine of Collagen Increases Uterine Fibroids Proliferation: Roles of Lysyl Hydroxylases, Lysyl Oxidases, and Matrix Metalloproteinases

(2017) Marwa Kamel et al.   Biomed Research International

Tissue Transglutaminase Modulates Vascular Stiffness and Function Through Crosslinking‐Dependent and Crosslinking‐Independent Functions

(2017) Jochen Steppan et al.   Journal of the American Heart Association

The Role of the Lysyl Oxidases in Tissue Repair and Remodeling: A Concise Review

(2017) Linyi Cai et al.   Tissue Engineering and Regenerative Medicine

Global identification and analysis of isozyme-specific possible substrates crosslinked by transglutaminases using substrate peptides in mouse liver fibrosis

(2017) Hideki Tatsukawa et al.   Scientific Reports

The Extracellular Matrix Signature in Vein Graft Disease

(2016) Birgit Kahle et al.   CANADIAN JOURNAL OF CARDIOLOGY

Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease

(2016) Rutger A. F. Gjaltema et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

A Tale of Two Joints: The Role of Matrix Metalloproteases in Cartilage Biology

(2016) Brandon J. Rose et al.   DISEASE MARKERS

Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice

(2016) Susan B. Liu et al.   FASEB JOURNAL

Fibroblast-Derived MMP-14 Regulates Collagen Homeostasis in Adult Skin

(2016) Paola Zigrino et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney

(2016) Chi Hua Sarah Lin et al.   KIDNEY INTERNATIONAL

Early cathepsin K degradation of type II collagen in vitro and in vivo in articular cartilage

(2016) J.S. Mort et al.   OSTEOARTHRITIS AND CARTILAGE

Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2

(2016) Rutger A. F. Gjaltema et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel insights into the function and dynamics of extracellular matrix in liver fibrosis

(2015) Morten A. Karsdal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

FK506-Binding Protein 10, a Potential Novel Drug Target for Idiopathic Pulmonary Fibrosis

(2015) Claudia A. Staab-Weijnitz et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Matrix cross-linking lysyl oxidases are induced in response to myocardial infarction and promote cardiac dysfunction

(2015) José González-Santamaría et al.   CARDIOVASCULAR RESEARCH

Collagen crosslinking does not dictate stiffness in a transgenic mouse model of skeletal muscle fibrosis

(2015) Mark A. Chapman et al.   JOURNAL OF BIOMECHANICS

Fibrosis — A Common Pathway to Organ Injury and Failure

(2015) Don C. Rockey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness

(2015) Dennis F. G. Remst et al.   RHEUMATOLOGY

Lysine post-translational modifications of collagen

(2014) Mitsuo Yamauchi et al.   Essays in Biochemistry

Transglutaminase Regulation of Cell Function

(2014) Richard L. Eckert et al.   PHYSIOLOGICAL REVIEWS

Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury

(2013) Maryna Perepelyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Lack of tissue renewal in human adult Achilles tendon is revealed by nuclear bomb 14C

(2013) Katja Maria Heinemeier et al.   FASEB JOURNAL

Collagen as a double-edged sword in tumor progression

(2013) Min Fang et al.   TUMOR BIOLOGY

Cellular Mechanisms of Tissue Fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis

(2012) Michael Zeisberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen

(2012) U. Schwarze et al.   HUMAN MOLECULAR GENETICS

Mutations in PLOD2 cause autosomal-recessive connective tissue disorders within the Bruck syndrome-Osteogenesis imperfecta phenotypic spectrum

(2012) Maria Trinidad Puig-Hervás et al.   HUMAN MUTATION

Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression

(2012) D.F.G. Remst et al.   OSTEOARTHRITIS AND CARTILAGE

Maternal Obesity Enhances Collagen Accumulation and Cross-Linking in Skeletal Muscle of Ovine Offspring

(2012) Yan Huang et al.   PLoS One

“It Is a Good Morning Exercise for a Research Scientist to Discard a Pet Hypothesis Every Day Before Breakfast: It Keeps Him Young” (Konrad Lorenz, 1903–1989)

(2011) John P. Iredale et al.   GASTROENTEROLOGY

Tissue Transglutaminase Does Not Affect Fibrotic Matrix Stability or Regression of Liver Fibrosis in Mice

(2011) Yury Popov et al.   GASTROENTEROLOGY

Differences in matrix composition between calvaria and long bone in mice suggest differences in biomechanical properties and resorption

(2008) T. van den Bos et al.   BONE

Collagen Turnover in Normal and Degenerate Human Intervertebral Discs as Determined by the Racemization of Aspartic Acid

(2008) Sarit-Sara Sivan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advances in collagen cross-link analysis

(2008) David R. Eyre et al.   METHODS