Revisiting hypoxia therapies for tuberculosis

Thrombocyte inhibition restores protective immunity to mycobacterial infection in zebrafish

(2019) Elinor Hortle et al.   JOURNAL OF INFECTIOUS DISEASES

Resolution of Large Choroidal Tuberculoma following Monotherapy with Intravitreal Ranibizumab

(2019) Sahil Jain et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

VEGF-A from Granuloma Macrophages Regulates Granulomatous Inflammation by a Non-angiogenic Pathway during Mycobacterial Infection

(2019) Jeffrey S. Harding et al.   Cell Reports

Platelets Regulate Pulmonary Inflammation and Tissue Destruction in Tuberculosis

(2018) Katharine A. Fox et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hyperbaric oxygen therapy increases the risk of tuberculosis disease

(2018) K-Y. Wang et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Limited Antimycobacterial Efficacy of Epitope Peptide Administration Despite Enhanced Antigen-Specific CD4 T-Cell Activation

(2018) Joel D Ernst et al.   JOURNAL OF INFECTIOUS DISEASES

Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

(2018) Cornelis J. Korbee et al.   Nature Communications

Matrix metalloproteinase inhibitors enhance the efficacy of frontline drugs against Mycobacterium tuberculosis

(2018) Yitian Xu et al.   PLoS Pathogens

Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis

(2018) Catherine W. M. Ong et al.   Scientific Reports

Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling

(2018) Eric M. Walton et al.   Cell Host & Microbe

Undernutrition and Tuberculosis: Public Health Implications

(2018) Pranay Sinha et al.   JOURNAL OF INFECTIOUS DISEASES

The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition

(2017) Gareth Prosser et al.   MICROBES AND INFECTION

Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis

(2016) Alimuddin Zumla et al.   BMC Medicine

Diabetes and cancer, common threads and missing links

(2016) Fang Hua et al.   CANCER LETTERS

T-cell exhaustion in tuberculosis: pitfalls and prospects

(2016) Nargis Khan et al.   CRITICAL REVIEWS IN MICROBIOLOGY

HIF-1α Is an Essential Mediator of IFN-γ–Dependent Immunity toMycobacterium tuberculosis

(2016) Jonathan Braverman et al.   JOURNAL OF IMMUNOLOGY

Infection-Induced Vascular Permeability Aids Mycobacterial Growth

(2016) Stefan H. Oehlers et al.   JOURNAL OF INFECTIOUS DISEASES

Hypoxia and tissue destruction in pulmonary TB

(2016) Moerida Belton et al.   THORAX

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

(2016) Macdonald Mahiti et al.   mBio

Immunometabolism in Tuberculosis

(2016) Lanbo Shi et al.   Frontiers in Immunology

Mycobacterium tuberculosis exploits the formation of new blood vessels for its dissemination

(2016) Helena Polena et al.   Scientific Reports

Lymphangiogenesis Is Induced by Mycobacterial Granulomas via Vascular Endothelial Growth Factor Receptor-3 and Supports Systemic T-Cell Responses against Mycobacterial Antigen

(2015) Jeffrey Harding et al.   AMERICAN JOURNAL OF PATHOLOGY

The DosR Regulon Modulates Adaptive Immunity and Is Essential forMycobacterium tuberculosisPersistence

(2015) Smriti Mehra et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Optic Nerve Head Tubercular Granuloma Successfully Treated with Anti-VEGF Intravitreal Injections in Addition to Systemic Therapy

(2015) Alessandro Invernizzi et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery

(2015) Meenal Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophages and cancer: from mechanisms to therapeutic implications

(2015) Renato Ostuni et al.   TRENDS IN IMMUNOLOGY

Tuberculosis and High Altitude. Worth a Try in Extensively Drug-Resistant Tuberculosis?

(2014) John F. Murray   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Diabetes and immunity to tuberculosis

(2014) Nuria Martinez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

From milk to rifampicin and back again: history of failures and successes in the treatment for tuberculosis

(2014) Michele A Riva   JOURNAL OF ANTIBIOTICS

Mycobacterium tuberculosisdysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation

(2014) André Kübler et al.   JOURNAL OF PATHOLOGY

Interception of host angiogenic signalling limits mycobacterial growth

(2014) Stefan H. Oehlers et al.   NATURE

The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells

(2014) Véronique Dartois   NATURE REVIEWS MICROBIOLOGY

Metformin as adjunct antituberculosis therapy

(2014) A. Singhal et al.   Science Translational Medicine

Unusual presentation of ocular tuberculosis: multiple chorioretinitis, retinal vasculitis and ischaemic central retinal vein occlusion

(2013) Erdem Yuksel et al.   Clinical and Experimental Optometry

Cutting Edge: Direct Recognition of Infected Cells by CD4 T Cells Is Required for Control of Intracellular Mycobacterium tuberculosis In Vivo

(2013) S. Srivastava et al.   JOURNAL OF IMMUNOLOGY

Statin Therapy Reduces the Mycobacterium tuberculosis Burden in Human Macrophages and in Mice by Enhancing Autophagy and Phagosome Maturation

(2013) Suraj P. Parihar et al.   JOURNAL OF INFECTIOUS DISEASES

Metabolic targets for cancer therapy

(2013) Lorenzo Galluzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Characterization of Phosphofructokinase Activity in Mycobacterium tuberculosis Reveals That a Functional Glycolytic Carbon Flow Is Necessary to Limit the Accumulation of Toxic Metabolic Intermediates under Hypoxia

(2013) Wai Yee Phong et al.   PLoS One

Effects of Ascent to High Altitude on Human Antimycobacterial Immunity

(2013) Sarah Eisen et al.   PLoS One

Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent Mechanism

(2013) Philip M. Elks et al.   PLoS Pathogens

Evaluation of a Mouse Model of Necrotic Granuloma Formation Using C3HeB/FeJ Mice for Testing of Drugs against Mycobacterium tuberculosis

(2012) Emily R. Driver et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function

(2012) Eóin N. McNamee et al.   IMMUNOLOGIC RESEARCH

Hypoxia Triggers the Expression of Human   Defensin 2 and Antimicrobial Activity against Mycobacterium tuberculosis in Human Macrophages

(2012) D. Nickel et al.   JOURNAL OF IMMUNOLOGY

Intravitreal bevacizumab as first local treatment for uveitis-related choroidal neovascularization: long-term results

(2011) Karina Julián et al.   ACTA OPHTHALMOLOGICA

Bevacizumab reverts serous retinal detachment caused by tuberculosis-associated immune reconstitution inflammatory syndrome

(2011) Matilde Ruiz-Cruz et al.   AIDS

Intravital Imaging Reveals Limited Antigen Presentation and T Cell Effector Function in Mycobacterial Granulomas

(2011) Jackson G. Egen et al.   IMMUNITY

Mouse Model of Necrotic Tuberculosis Granulomas Develops Hypoxic Lesions

(2011) Jamie Harper et al.   JOURNAL OF INFECTIOUS DISEASES

Hypoxia: a window intoMycobacterium tuberculosislatency

(2009) Tige R. Rustad et al.   CELLULAR MICROBIOLOGY

Intravitreal bevacizumab as an adjunct in a patient with presumed vascularised choroidal tubercular granuloma

(2009) K Babu et al.   EYE

Foamy macrophages and the progression of the human tuberculosis granuloma

(2009) David G Russell et al.   NATURE IMMUNOLOGY

Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium

(2009) H. E. Volkman et al.   SCIENCE

Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates

(2008) L. E. Via et al.   INFECTION AND IMMUNITY

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

(2008) S. P. S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuberculosis in Turkey: high altitude and other socio-economic risk factors

(2008) A.C. Tanrikulu et al.   PUBLIC HEALTH