Upcoming candidate cerebrospinal fluid biomarkers of Alzheimer’s disease

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

(2017) John P. Cogswell et al.   JOURNAL OF ALZHEIMERS DISEASE

Glial Fibrillary Acidic Protein and Protein S-100B: Different Concentration Pattern of Glial Proteins in Cerebrospinal Fluid of Patients with Alzheimer's Disease and Creutzfeldt-Jakob Disease

(2017) Sarah Jesse et al.   JOURNAL OF ALZHEIMERS DISEASE

Reduced Levels of Amyloid-β-Binding Proteins in Cerebrospinal Fluid from Alzheimer's Disease Patients

(2017) Sara F. Hansson et al.   JOURNAL OF ALZHEIMERS DISEASE

Gelsolin is Proteolytically Cleaved in the Brains of Individuals with Alzheimer's Disease

(2017) Lina Ji et al.   JOURNAL OF ALZHEIMERS DISEASE

Biomarkers as Predictors for Conversion from Mild Cognitive Impairment to Alzheimer-Type Dementia: Implications for Trial Design

(2017) Ineke A. van Rossum et al.   JOURNAL OF ALZHEIMERS DISEASE

BACE1 Activity in Cerebrospinal Fluid and Its Relation to Markers of AD Pathology

(2017) Sandra D. Mulder et al.   JOURNAL OF ALZHEIMERS DISEASE

CSF Neurofilament Proteins Levels are Elevated in Sporadic Creutzfeldt-Jakob Disease

(2017) Jeroen J.J. van Eijk et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

Cerebrospinal Fluid Aβ and Tau Level Fluctuation in an Older Clinical Cohort

(2012) Abhay Moghekar   ARCHIVES OF NEUROLOGY

Antioxidants for Alzheimer Disease

(2012) Douglas R. Galasko et al.   ARCHIVES OF NEUROLOGY

MicroRNAs in Stress Signaling and Human Disease

(2012) Joshua T. Mendell et al.   CELL

In Vivo MicroRNA Detection and Quantitation in Cerebrospinal Fluid

(2012) Juan A. Gallego et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Earliest Stage of Cognitive Impairment in Transition From Normal Aging to Alzheimer Disease Is Marked by Prominent RNA Oxidation in Vulnerable Neurons

(2012) Akihiko Nunomura et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

(2012) Thomas G. Beach et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Brain Injury Biomarkers May Improve the Predictive Power of the IMPACT Outcome Calculator

(2012) Endre Czeiter et al.   JOURNAL OF NEUROTRAUMA

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

(2012) Iryna Benilova et al.   NATURE NEUROSCIENCE

MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity

(2012) N. M. Teplyuk et al.   NEURO-ONCOLOGY

CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease

(2012) R. Tarawneh et al.   NEUROLOGY

Cerebrospinal Fluid Profiles of Amyloid β-Related Biomarkers in Alzheimer’s Disease

(2012) Christoffer Rosén et al.   NEUROMOLECULAR MEDICINE

CCL2 Is Associated with a Faster Rate of Cognitive Decline during Early Stages of Alzheimer's Disease

(2012) Karin Westin et al.   PLoS One

Metabolite Profiling of Alzheimer's Disease Cerebrospinal Fluid

(2012) Christian Czech et al.   PLoS One

CSF-Biomarkers in Olympic Boxing: Diagnosis and Effects of Repetitive Head Trauma

(2012) Sanna Neselius et al.   PLoS One

National estimates of the prevalence of Alzheimer’s disease in the United States

(2011) Ron Brookmeyer et al.   Alzheimers & Dementia

The Alzheimer’s Association external quality control program for cerebrospinal fluid biomarkers

(2011) Niklas Mattsson et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Complement 3 and Factor H in Human Cerebrospinal Fluid in Parkinson's Disease, Alzheimer's Disease, and Multiple-System Atrophy

(2011) Yu Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Actions of β-Amyloid Protein on Human Neurons Are Expressed through the Amylin Receptor

(2011) Jack H. Jhamandas et al.   AMERICAN JOURNAL OF PATHOLOGY

Visinin-like protein-1: Diagnostic and prognostic biomarker in Alzheimer disease

(2011) Rawan Tarawneh et al.   ANNALS OF NEUROLOGY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Longitudinal Change of Biomarkers in Cognitive Decline

(2011) Raymond Y. Lo   ARCHIVES OF NEUROLOGY

Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system

(2011) A. Baraniskin et al.   BLOOD

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

(2011) M. T. Fodero-Tavoletti et al.   BRAIN

Astrocyte and Macrophage Regulation of YKL-40 Expression and Cellular Response in Neuroinflammation

(2011) Dafna Bonneh-Barkay et al.   BRAIN PATHOLOGY

Modeling of Pathological Traits in Alzheimer's Disease Based on Systemic Extracellular Signaling Proteome

(2011) Markus Britschgi et al.   MOLECULAR & CELLULAR PROTEOMICS

Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease

(2011) Hong Jiang et al.   Molecular Neurodegeneration

Pervasive roles of microRNAs in cardiovascular biology

(2011) Eric M. Small et al.   NATURE

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

Multimodal classification of Alzheimer's disease and mild cognitive impairment

(2011) Daoqiang Zhang et al.   NEUROIMAGE

CSF soluble amyloid precursor proteins in the diagnosis of incipient Alzheimer disease

(2011) R. Perneczky et al.   NEUROLOGY

Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease

(2011) Richard J. Perrin et al.   PLoS One

Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis

(2011) Rebecca Craig-Schapiro et al.   PLoS One

Peptide Fingerprinting of Alzheimer's Disease in Cerebrospinal Fluid: Identification and Prospective Evaluation of New Synaptic Biomarkers

(2011) Holger Jahn et al.   PLoS One

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Novel CSF biomarkers for Alzheimer’s disease and mild cognitive impairment

(2010) William T. Hu et al.   ACTA NEUROPATHOLOGICA

Biomarker discovery for Alzheimer’s disease, frontotemporal lobar degeneration, and Parkinson’s disease

(2010) William T. Hu et al.   ACTA NEUROPATHOLOGICA

A Meta-Analysis of Cytokines in Alzheimer's Disease

(2010) Walter Swardfager et al.   BIOLOGICAL PSYCHIATRY

YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

(2010) Rebecca Craig-Schapiro et al.   BIOLOGICAL PSYCHIATRY

Correlations between soluble α/β forms of amyloid precursor protein and Aβ38, 40, and 42 in human cerebrospinal fluid

(2010) Audrey Gabelle et al.   BRAIN RESEARCH

Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease

(2010) Annika Thorsell et al.   BRAIN RESEARCH

The MicroRNA Spectrum in 12 Body Fluids

(2010) J. A. Weber et al.   CLINICAL CHEMISTRY

Tau Truncation is a Productive Posttranslational Modification of Neurofibrillary Degeneration in Alzheimers Disease

(2010) B. Kovacech et al.   Current Alzheimer Research

Increased Levels of Soluble LR11 in Cerebrospinal Fluid of Patients with Alzheimer Disease

(2010) Takeshi Ikeuchi et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

High-molecular-weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients

(2010) Hiroaki Fukumoto et al.   FASEB JOURNAL

In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases

(2010) Dafna Bonneh-Barkay et al.   Journal of Neuroinflammation

Distinct cerebrospinal fluid amyloid β peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease

(2010) Erik Portelius et al.   Molecular Neurodegeneration

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

(2010) Kaj Blennow et al.   Nature Reviews Neurology

Novel CSF biomarkers for frontotemporal lobar degenerations

(2010) W. T. Hu et al.   NEUROLOGY

Comparing predictors of conversion and decline in mild cognitive impairment

(2010) S. M. Landau et al.   NEUROLOGY

Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum*

(2010) Douglas D. Fraser et al.   Pediatric Critical Care Medicine

Aβ40 Oligomers Identified as a Potential Biomarker for the Diagnosis of Alzheimer's Disease

(2010) Carol Man Gao et al.   PLoS One

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

(2010) Andrei G. Vlassenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biomarkers for Alzheimer's disease therapeutic trials

(2010) Harald Hampel et al.   PROGRESS IN NEUROBIOLOGY

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

(2009) Akihiko Nunomura et al.   ACTA NEUROPATHOLOGICA

A γ-secretase inhibitor decreases amyloid-β production in the central nervous system

(2009) Randall J. Bateman et al.   ANNALS OF NEUROLOGY

Cerebrospinal Fluid Biomarkers and Rate of Cognitive Decline in Very Mild Dementia of the Alzheimer Type

(2009) Barbara J. Snider et al.   ARCHIVES OF NEUROLOGY

Reduction of SorLA/LR11, a Sorting Protein Limiting β-Amyloid Production, in Alzheimer Disease Cerebrospinal Fluid

(2009) Qiu-Lan Ma et al.   ARCHIVES OF NEUROLOGY

Beta Amyloid in Alzheimer's Disease: Increased Deposition in Brain Is Reflected in Reduced Concentration in Cerebrospinal Fluid

(2009) Timo Grimmer et al.   BIOLOGICAL PSYCHIATRY

Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases

(2009) Guo Nan Yin et al.   BRAIN RESEARCH

Neurobiochemical Markers of Brain Damage in Cerebrospinal Fluid of Acute Ischemic Stroke Patients

(2009) R. Brouns et al.   CLINICAL CHEMISTRY

Rapid Progression from Mild Cognitive Impairment to Alzheimer’s Disease in Subjects with Elevated Levels of Tau in Cerebrospinal Fluid and the APOE ε4/ε4 Genotype

(2009) Elin S. Blom et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Cerebrospinal fluid tau and ptau181increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease

(2009) Anne M. Fagan et al.   EMBO Molecular Medicine

Growth factors and cytokines/chemokines as surrogate biomarkers in cerebrospinal fluid and blood for diagnosing Alzheimer’s disease and mild cognitive impairment

(2009) Lars Olson et al.   EXPERIMENTAL GERONTOLOGY

Plasminogen activator activity is inhibited while neuroserpin is up-regulated in the Alzheimer disease brain

(2009) Shay Fabbro et al.   JOURNAL OF NEUROCHEMISTRY

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

Relationship of Cerebrospinal Fluid Markers to 11C-PiB and 18F-FDDNP Binding

(2009) N. Tolboom et al.   JOURNAL OF NUCLEAR MEDICINE

MRI and CSF biomarkers in normal, MCI, and AD subjects: Diagnostic discrimination and cognitive correlations

(2009) P. Vemuri et al.   NEUROLOGY

Relationships between biomarkers in aging and dementia

(2009) W. J. Jagust et al.   NEUROLOGY

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Matrix metalloproteinases-2 and -3 are reduced in cerebrospinal fluid with low beta-amyloid1–42 levels

(2009) Reinhilde Mlekusch et al.   NEUROSCIENCE LETTERS

S100A7, a Novel Alzheimer's Disease Biomarker with Non-Amyloidogenic α-Secretase Activity Acts via Selective Promotion of ADAM-10

(2009) Weiping Qin et al.   PLoS One

A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease

(2009) N A Verwey et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Metabolomics: A Global Biochemical Approach to Drug Response and Disease

(2008) Rima Kaddurah-Daouk et al.   Annual Review of Pharmacology and Toxicology

Elevated Cerebrospinal Fluid BACE1 Activity in Incipient Alzheimer Disease

(2008) Henrik Zetterberg et al.   ARCHIVES OF NEUROLOGY

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer’s disease

(2008) Julius Popp et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Glial and Axonal Body Fluid Biomarkers Are Related to Infarct Volume, Severity, and Outcome

(2008) Axel Petzold et al.   Journal of Stroke & Cerebrovascular Diseases

Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study

(2008) P Lewczuk et al.   MOLECULAR PSYCHIATRY

Soluble TNF receptors are associated with Aβ metabolism and conversion to dementia in subjects with mild cognitive impairment

(2008) Peder Buchhave et al.   NEUROBIOLOGY OF AGING

Biochemical markers in persons with preclinical familial Alzheimer disease

(2008) J. M. Ringman et al.   NEUROLOGY

Identification of a novel panel of cerebrospinal fluid biomarkers for Alzheimer's disease

(2007) A.H. Simonsen et al.   NEUROBIOLOGY OF AGING

PET imaging of amyloid deposition in patients with mild cognitive impairment

(2007) Anton Forsberg et al.   NEUROBIOLOGY OF AGING

Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment

(2007) Miroslaw Brys et al.   NEUROBIOLOGY OF AGING