mTOR Signalling in Head and Neck Cancer: Heads Up

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

(2019) Tian Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutations in SZT2 result in early-onset epileptic encephalopathy and leukoencephalopathy

(2018) Amy Pizzino et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Mevalonate pathway blockage enhances the efficacy of mTOR inhibitors with the activation of retinoblastoma protein in renal cell carcinoma

(2018) Nobuhisa Hagiwara et al.   CANCER LETTERS

mTORC2 contributes to the metabolic reprogramming in EGFR tyrosine-kinase inhibitor resistant cells in non-small cell lung cancer

(2018) Chun-Te Chiang et al.   CANCER LETTERS

Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer

(2018) Toni M. Brand et al.   CANCER RESEARCH

Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex

(2018) Anastasios Gkountakos et al.   CARCINOGENESIS

Human papillomavirus prevalence in a Mid-European oral squamous cell cancer population: A cohort study

(2018) Daniel Dalla Torre et al.   ORAL DISEASES

Immunohistochemical expression of epidermal growth factor receptor (EGFR) in South Asian head and neck squamous cell carcinoma: association with various risk factors and clinico-pathologic and prognostic parameters

(2018) Atif Ali hashmi et al.   World Journal of Surgical Oncology

The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells

(2018) Robert Kleszcz et al.   Advances in Clinical and Experimental Medicine

FAT1 somatic mutations in head and neck carcinoma are associated with tumor progression and survival

(2018) Shu-Chun Lin et al.   CARCINOGENESIS

Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma

(2018) Michaela Plath et al.   Journal of Otolaryngology-Head & Neck Surgery

ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition

(2018) Kara M. Ruicci et al.   ORAL ONCOLOGY

Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma

(2018) Takafumi Nakagaki et al.   TUMOR BIOLOGY

Hyperprogressive disease: recognizing a novel pattern to improve patient management

(2018) Stéphane Champiat et al.   Nature Reviews Clinical Oncology

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

(2018) Manal Mehibel et al.   Scientific Reports

Genomic and Transcriptomic Characterization Links Cell Lines with Aggressive Head and Neck Cancers

(2018) Hui Cheng et al.   Cell Reports

Long-Lived Epidermal Cancer-Initiating Cells

(2017) Marina Youssef et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of human papillomavirus in p16-positive oral cancers

(2017) Simone Belobrov et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

SZT2 dictates GATOR control of mTORC1 signalling

(2017) Min Peng et al.   NATURE

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

(2017) Rachel L. Wolfson et al.   NATURE

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition

(2017) Deepti Mathur et al.   Cancer Discovery

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer

(2017) Riley A. Hampsch et al.   Oncotarget

PLD1 overexpression promotes invasion and migration and function as a risk factor for Chinese glioma patients

(2017) Wenjun Tang et al.   Oncotarget

HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer

(2017) Young-Suk Jung et al.   Oncotarget

Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities

(2017) Shih-Chi Su et al.   Theranostics

Identification of Key Genes and Pathways in Tongue Squamous Cell Carcinoma Using Bioinformatics Analysis

(2017) Huayong Zhang et al.   MEDICAL SCIENCE MONITOR

Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line

(2017) Chung-Ho E. Lau et al.   Scientific Reports

Clinicopathological and prognostic significance of mTOR and phosphorylated mTOR expression in patients with esophageal squamous cell carcinoma: a systematic review and meta-analysis

(2016) Shuangjiang Li et al.   BMC CANCER

mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer

(2016) David R. Driscoll et al.   CANCER RESEARCH

mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model

(2016) Juan Luis Callejas-Valera et al.   CARCINOGENESIS

Therapeutic inhibition of phospholipase D1 suppresses hepatocellular carcinoma

(2016) J. Xiao et al.   CLINICAL SCIENCE

Poor prognosis in human papillomavirus-positive oropharyngeal squamous cell carcinomas that overexpress hypoxia inducible factor-1α

(2016) Justin Egidius Swartz et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

p53 and p16 in oral epithelial dysplasia and oral squamous cell carcinoma: A study of 208 cases

(2016) ElbaRosa Leyva Huerta et al.   Indian Journal of Pathology and Microbiology

Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort

(2016) Laura Q.M. Chow et al.   JOURNAL OF CLINICAL ONCOLOGY

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

(2016) Lei Li et al.   JOURNAL OF HEPATOLOGY

Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life

(2016) Michael Cangkrama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2

(2016) Stephen B. Keysar et al.   JNCI-Journal of the National Cancer Institute

Notch1 signaling contributes to stemness in head and neck squamous cell carcinoma

(2016) Sang H Lee et al.   LABORATORY INVESTIGATION

Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial

(2016) Tanguy Y Seiwert et al.   LANCET ONCOLOGY

The role of barrier genes in epidermal malignancy

(2016) C Darido et al.   ONCOGENE

Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer

(2016) P L Martin et al.   ONCOGENE

The role of autophagy in squamous cell carcinoma of the head and neck

(2016) Benjamin Cosway et al.   ORAL ONCOLOGY

p16 and p53 expression status in head and neck squamous cell carcinoma: a correlation with histological, histoprognostic and clinical parameters

(2016) Georgia Karpathiou et al.   PATHOLOGY

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

(2016) Shohei Koyama et al.   Nature Communications

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

(2016) Yujun Hao et al.   Nature Communications

PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells

(2016) Camila S. Matsumoto et al.   Oncotarget

Simultaneous high expression of PLD1 and Sp1 predicts a poor prognosis for pancreatic ductal adenocarcinoma patients

(2016) Jiong Hu et al.   Oncotarget

Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2

(2016) Stephen B. Keysar et al.   JNCI-Journal of the National Cancer Institute

Enhanced Tumor Control with Combination mTOR and PD-L1 Inhibition in Syngeneic Oral Cavity Cancers

(2016) E. C. Moore et al.   Cancer Immunology Research

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas

(2015) Moshe Elkabets et al.   CANCER CELL

Prevention of Tumor Growth Driven by PIK3CA and HPV Oncogenes by Targeting mTOR Signaling with Metformin in Oral Squamous Carcinomas Expressing OCT3

(2015) D. Madera et al.   Cancer Prevention Research

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex

(2015) Y. Feng et al.   CANCER RESEARCH

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

(2015) Hideki Makinoshima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of cigarette smoking and alcohol consumption in the differentiation of oral squamous cell carcinoma for the males in China

(2015) Huiming Wang et al.   Journal of Cancer Research and Therapeutics

Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma

(2015) Smitha R. Georgy et al.   JNCI-Journal of the National Cancer Institute

Combination of mTOR and EGFR targeting in an orthotopic xenograft model of head and neck cancer

(2015) Alexandre Bozec et al.   LARYNGOSCOPE

mTORC2 Balances AKT Activation and eIF2  Serine 51 Phosphorylation to Promote Survival under Stress

(2015) C. Tenkerian et al.   MOLECULAR CANCER RESEARCH

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

(2015) S J H Ricoult et al.   ONCOGENE

Rare occurrence of EGFRvIII deletion in head and neck squamous cell carcinoma

(2015) Arun Khattri et al.   ORAL ONCOLOGY

Increase in head and neck cancer in younger patients due to human papillomavirus (HPV)

(2015) David Young et al.   ORAL ONCOLOGY

Review The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge

(2015) Katarzyna Tomczak et al.   Wspolczesna Onkologia-Contemporary Oncology

Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma

(2015) Smitha R. Georgy et al.   JNCI-Journal of the National Cancer Institute

Tumor suppression by small molecule inhibitors of translation initiation

(2015) Limo Chen et al.   Oncotarget

The predictive value ofKRAS, NRAS, BRAF, PIK3CAand PTEN for anti-EGFR treatment in metastatic colorectal cancer: A systematic review and meta-analysis

(2014) Christina Therkildsen et al.   ACTA ONCOLOGICA

TEMHEAD: a single-arm multicentre phase II study of temsirolimus in platin- and cetuximab refractory recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN) of the German SCCHN Group (AIO)†

(2014) V. Grünwald et al.   ANNALS OF ONCOLOGY

Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis

(2014) V Bagnardi et al.   BRITISH JOURNAL OF CANCER

Prognostic significance of p62/SQSTM1 subcellular localization and LC3B in oral squamous cell carcinoma

(2014) J-L Liu et al.   BRITISH JOURNAL OF CANCER

RAS/PI3K Crosstalk and Cetuximab Resistance in Head and Neck Squamous Cell Carcinoma

(2014) T. Rampias et al.   CLINICAL CANCER RESEARCH

Cetuximab plus radiotherapy for the treatment of locally advanced squamous cell carcinoma of the head and neck

(2014) S Griffin et al.   HEALTH TECHNOLOGY ASSESSMENT

Decreased Expression of EIF4A1 After Preoperative Brachytherapy Predicts Better Tumor-Specific Survival in Cervical Cancer

(2014) Shanhui Liang et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

PTENMutations and Activation of the PI3K/Akt/mTOR Signaling Pathway in Papillary Tumors of the Pineal Region

(2014) Tobias Goschzik et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Correlation of ALDH1, CD44, OCT4 and SOX2 in tongue squamous cell carcinoma and their association with disease progression and prognosis

(2014) Cong-Fa Huang et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations

(2014) Zhiyong Wang et al.   JNCI-Journal of the National Cancer Institute

Inhibition of Monocarboxylate Transporter-1 (MCT1) by AZD3965 Enhances Radiosensitivity by Reducing Lactate Transport

(2014) B. M. Bola et al.   MOLECULAR CANCER THERAPEUTICS

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

(2014) E. Papadopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

(2014) B. C. Grabiner et al.   Cancer Discovery

The Effects of GLUT1 on the Survival of Head and Neck Squamous Cell Carcinoma

(2013) Shengjiao Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Increasing the therapeutic efficacy of docetaxel for cutaneous squamous cell carcinoma through the combined inhibition of phosphatidylinositol 3-kinase/AKT signalling and autophagy

(2013) T. J. Wright et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Activity of the Monocarboxylate Transporter 1 Inhibitor AZD3965 in Small Cell Lung Cancer

(2013) R. Polanski et al.   CLINICAL CANCER RESEARCH

HRAS mutations and resistance to the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in head and neck squamous cell carcinoma cells

(2013) J. Hun Hah et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

High LC3 expression correlates with poor survival in patients with oral squamous cell carcinoma

(2013) Jen-Yang Tang et al.   HUMAN PATHOLOGY

Stem Cells behind the Barrier

(2013) Michael Cangkrama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The pathological significance of Notch1 in oral squamous cell carcinoma

(2013) Ryoji Yoshida et al.   LABORATORY INVESTIGATION

Altered glucose metabolism in Harvey-rastransformed MCF10A cells

(2013) Wei Zheng et al.   MOLECULAR CARCINOGENESIS

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

(2013) Pengda Liu et al.   NATURE CELL BIOLOGY

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of mTOR Reduces Anal Carcinogenesis in Transgenic Mouse Model

(2013) Zhi-Jun Sun et al.   PLoS One

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Hexokinase 2 overexpression promotes the proliferation and survival of laryngeal squamous cell carcinoma

(2013) Jian Chen et al.   TUMOR BIOLOGY

Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers

(2013) V. W. Y. Lui et al.   Cancer Discovery

Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers

(2013) C. R. Pickering et al.   Cancer Discovery

Expression of glucose transporters in cancers

(2012) Leszek Szablewski   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma

(2012) Toshihito Suda et al.   BMC CANCER

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

Carfilzomib and ONX 0912 Inhibit Cell Survival and Tumor Growth of Head and Neck Cancer and Their Activities Are Enhanced by Suppression of Mcl-1 or Autophagy

(2012) Y. Zang et al.   CLINICAL CANCER RESEARCH

Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model

(2012) Z.-J. Sun et al.   CLINICAL CANCER RESEARCH

mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas

(2012) A. A. Molinolo et al.   CLINICAL CANCER RESEARCH

Synergistic Antiproliferative and Antiangiogenic Effects of EGFR and mTOR Inhibitors

(2012) L. Porcelli et al.   CURRENT PHARMACEUTICAL DESIGN

Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase

(2012) Brenda L. Montalvo-Ortiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rictor regulates cell migration by suppressing RhoGDI2

(2012) N K Agarwal et al.   ONCOGENE

Novel mutations of the HRAS gene and absence of hotspot mutations of the BRAF genes in oral squamous cell carcinoma in a Greek population

(2012) Dimitra Koumaki   ONCOLOGY REPORTS

Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis

(2011) Charbel Darido et al.   CANCER CELL

Rapamycin and mTORC1 Inhibition in the Mouse: Skin Cancer Prevention

(2011) Mohammad Athar et al.   Cancer Prevention Research

mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways

(2011) P. Gulhati et al.   CANCER RESEARCH

Phosphatidic Acid Activates Mammalian Target of Rapamycin Complex 1 (mTORC1) Kinase by Displacing FK506 Binding Protein 38 (FKBP38) and Exerting an Allosteric Effect

(2011) Mee-Sup Yoon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

(2011) Abdelhafid Saci et al.   MOLECULAR CELL

Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation

(2011) Y Bian et al.   ONCOGENE

Radioresistant head and neck squamous cell carcinoma cells: Intracellular signaling, putative biomarkers for tumor recurrences and possible therapeutic targets

(2011) Sergej Skvortsov et al.   RADIOTHERAPY AND ONCOLOGY

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with HPV16 E7 oncoprotein

(2011) Vito Rodolico et al.   Infectious Agents and Cancer

Phosphatidic acid mediates activation of mTORC1 through the ERK signaling pathway

(2010) Jeremiah N. Winter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dual inhibition of EGFR and mTOR pathways in small cell lung cancer

(2010) K Schmid et al.   BRITISH JOURNAL OF CANCER

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

HPV-associated head and neck cancer: a virus-related cancer epidemic

(2010) Shanthi Marur et al.   LANCET ONCOLOGY

Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma

(2010) Luxia Tu et al.   Molecular Cancer

Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer

(2010) K. Kian Ang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Changes in Survival in Head and Neck Cancers in the Late 20th and Early 21st Century: A Period Analysis

(2010) D. Pulte et al.   ONCOLOGIST

Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F

(2010) R. Cencic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Total Exposure and Exposure Rate Effects for Alcohol and Smoking and Risk of Head and Neck Cancer: A Pooled Analysis of Case-Control Studies

(2009) J. H. Lubin et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity

(2009) Jana A. Lewis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Mammalian Target of Rapamycin by Rapamycin Prevents Tumor Progression in an Oral-Specific Chemical Carcinogenesis Model

(2009) R. Czerninski et al.   Cancer Prevention Research

Szt2, a novel gene for seizure threshold in mice

(2009) W. N. Frankel et al.   GENES BRAIN AND BEHAVIOR

Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study

(2009) Ezra EW Cohen et al.   LANCET ONCOLOGY

Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer

(2009) Deborah Silvera et al.   NATURE CELL BIOLOGY

Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer

(2009) Avaniyapuram Kannan Murugan et al.   ORAL ONCOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

High Incidence of Oral Dysesthesias on a Trial of Gefitinib, Paclitaxel, and Concurrent External Beam Radiation for Locally Advanced Head and Neck Cancers

(2008) Hadley Sharp et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

(2008) Carolyn L. Buller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

KAI1/CD82 decreases Rac1 expression and cell proliferation through PI3K/Akt/mTOR pathway in H1299 lung carcinoma cells

(2008) Un-Jong Choi et al.   CELL BIOCHEMISTRY AND FUNCTION

Inhibition of Mammalian Target of Rapamycin by Rapamycin Causes the Regression of Carcinogen-Induced Skin Tumor Lesions

(2008) P. Amornphimoltham et al.   CLINICAL CANCER RESEARCH

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

(2008) Francisco Ramírez-Valle et al.   JOURNAL OF CELL BIOLOGY

Incidence Trends for Human Papillomavirus–Related and –Unrelated Oral Squamous Cell Carcinomas in the United States

(2008) Anil K. Chaturvedi et al.   JOURNAL OF CLINICAL ONCOLOGY