Article
Gastroenterology & Hepatology
Smitha Rose Georgy, Diar Riyanti Rudiatmoko, Alana Auden, Darren Partridge, Tariq Butt, Seema Srivastava, Nick Wong, Dijina Swaroop, Marina Rose Carpinelli, Mirjana Bogeski, Stephen M. Jane
Summary: The transcription factor GRHL3 functions as a tumor suppressor in esophageal squamous cell carcinoma by regulating HOPX expression and Wnt signaling. The study highlights the potential of targeted therapies against the Wnt/beta-catenin pathways in patients with reduced GRHL3 expression.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Xiang Wu, Jin Li, Tingyuan Yan, Xueping Ke, Xin Li, Yumin Zhu, Jianrong Yang, Zhongwu Li
Summary: HOXB7 is overexpressed in HNSCC and associated with tumor aggressiveness and poor prognosis, serving as a potential therapeutic target in HNSCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Neha Khera, Asvika Soodhalaagunta Rajkumar, Khlood Abdulkader M. Alkurdi, Zhiao Liu, Hong Ma, Ahmad Waseem, Muy-Teck Teh
Summary: Through transcriptome datamining, 10 multidrug chemoresistance genes were identified in head and neck squamous cell carcinoma. Among them, NEK2 and INHBA showed significant prognostic values in multiple cancer types. Drug library screens discovered two compounds targeting INHBA and NEK2, which resensitized cisplatin-resistant cells.
Article
Biotechnology & Applied Microbiology
Cheng Lin, Yuebing Chen, Jianji Pan, Qiongjiao Lu, Pengjie Ji, Shuiqin Lin, Chunfeng Liu, Shaojun Lin, Meifang Li, Jingfeng Zong
Summary: This study aimed to construct a risk model based on therapeutic response-related genes (TRRGs) to predict therapy response and prognosis in TRRGs-defined subgroups of head and neck squamous cell carcinoma (HNSCC). By analyzing data from TCGA and GEO databases, differentially expressed TRRGs significantly associated with survival were identified, and a signature and prognostic nomogram based on TRRGs were established. The results showed that the model could effectively predict therapy response and overall survival in HNSCC patients.
Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Chao Huang, Yun Liang, Yi Dong, Li Huang, Anlei Li, Ran Du, Hao Huang
Summary: This study establishes a novel prognostic model for head and neck squamous cell carcinoma (HNSCC) based on six matrisome genes. The high-risk group has worse prognosis and higher enrichment of pathways associated with cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xin Zhou, Xiaoshen Wang
Summary: This review provides a detailed illustration of the biology, genomic features, and immune landscapes of HPV-associated HNSCC, supporting the synergistic effect of radioimmunotherapy. Current evidence and ongoing clinical trials suggest the potential of radioimmunotherapy in recurrent/metastatic or definitive settings. Future challenges include optimization of radiotherapy and the incorporation of novel therapeutic options.
Article
Cell Biology
Qiu-Shuang Xu, Zheng-Zhong Shen, Ling-Qing Yuan
Summary: This study developed a novel prediction model based on cuproptosis-related lncRNAs, which can evaluate survival and tumor immunity in patients with HNSCC and predict the efficacy of immunotherapy and targeted therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Rocio Granda-Diaz, Lorea Manterola, Francisco Hermida-Prado, Rene Rodriguez, Laura Santos, Vanessa Garcia-de-la-Fuente, Maria Teresa Fernandez, M. Daniela Corte-Torres, Juan P. Rodrigo, Saul Alvarez-Teijeiro, Charles H. Lawrie, Juana M. Garcia-Pedrero
Summary: Treatment of head and neck squamous cell carcinomas (HNSCC) remains challenging. Dysregulation of miRNA is closely linked to tumorigenesis and tumor progression, making it a suitable target for cancer treatment. In this study, miR-301a was found to be overexpressed in HNSCC tumors and was shown to play a role in promoting tumor growth and invasion. The PI3K/PTEN/AKT and MEK/ERK pathways were identified as central signaling nodes responsible for mediating the oncogenic activity of miR-301a.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Yun Chen, Yaqiong Zhao, Ruohuang Lu, Han Zhao, Yue Guo
Summary: Researchers developed a genomic instability-associated lncRNA prognostic signature (GILncSig) for evaluating survival outcomes in HNSCC patients by analyzing RNA-sequencing data and patient clinical information. The signature was successfully validated in a testing cohort and demonstrated strong predictive ability for HNSCC prognosis. It was identified as an independent predictor of prognosis and showed potential as therapeutic targets for HNSCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Vaishali Chandel, Saurabh Maru, Arun Kumar, Ashok Kumar, Ashok Sharma, Brijesh Rathi, Dhruv Kumar
Summary: Head and Neck tumors exhibit highly altered metabolism, with cancer cells utilizing different pathways for energy production. Monocarboxylate transporters play a crucial role in regulating lactate and maintaining pH balance, essential for cancer cell survival and growth control.
Article
Biochemistry & Molecular Biology
Hui Li, Xiaomin Wang, Mingjie Zhang, Mengjun Wang, Junjie Zhang, Shiyin Ma
Summary: Hox genes, highly conserved across animals, play vital roles in cell development and organ formation. Recent studies have shown their involvement in tumorigenesis, particularly in head and neck squamous cell carcinoma (HNSCC) progression. High expression of HOXA1 is correlated with poor prognosis indicators in HNSCC, suggesting it as an independent prognostic marker.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Ming Shi, Jiangnan Du, Jingjing Shi, Yunchuanxiang Huang, Yan Zhao, Lan Ma
Summary: This study reveals the high expression level of ferroptosis-related factor ATG5 in HNSCC and NPC patients, which is correlated with poor prognosis and the expression of immune checkpoints. HNSCC patients with high expression of ATG5 showed poor response to immune checkpoint blockade therapy. Furthermore, ATG5 is associated with the G2M checkpoint pathway, indicating the potential value of G2M inhibitors in HNSCC/NPC treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ching-Yun Hsieh, Ching-Chan Lin, Wei-Chao Chang
Summary: Taxanes, especially docetaxel, are widely used in combination therapy for head and neck squamous cell carcinoma (HNSCC) and have shown advantages in improving patient outcomes. Taxanes not only function as antimitotics, but also impair various oncogenic signaling pathways. However, the development of drug resistance remains a major obstacle to treatment response.
Review
Pharmacology & Pharmacy
Yujie Xi, Ling Gao, Shaming Li, Kai Sun, Peishen Chen, Zhen Cai, Wenhao Ren, Keqian Zhi
Summary: This article summarizes the roles of novel programmed cell death in the development of HNSCC and discusses potential therapeutic approaches.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Zhen Yu, Jennifer Nguyen, Toan D. Nguyen, John Kelly, Catriona Mclean, Paul Bonnington, Lei Zhang, Victoria Mar, Zongyuan Ge
Summary: This study proposes a framework for automated early melanoma diagnosis using sequential dermoscopic images. By aligning images, extracting lesion growth regions, and constructing a spatio-temporal network, accurate diagnosis of melanoma is achieved. Experimental results show that the proposed model outperforms other commonly used models in the early diagnosis of melanoma, with higher diagnostic accuracy and earlier diagnosis time compared to clinicians.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2022)
Editorial Material
Biochemistry & Molecular Biology
Tomasz Wilanowski, Sebastian Dworkin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jemma G. Gasperoni, Jarrad N. Fuller, Charbel Darido, Tomasz Wilanowski, Sebastian Dworkin
Summary: Grainyhead-like (GRHL) factors are critical transcription factors that regulate cellular behaviors during development and in cancer. Identifying and studying the target genes of these factors are essential for discovering potential targets for disease diagnosis, drug discovery, and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Oncology
Imran Khan, Charbel Darido
Article
Cardiac & Cardiovascular Systems
Chris Anthony, Muhammad Imran, Jim Pouliopoulos, Sam Emmanuel, James Iliff, Zhixin Liu, Kirsten Moffat, Min Ru Qiu, Catriona A. McLean, Christian Stehning, Valentina Puntmann, Vass Vassiliou, Tevfik F. Ismail, Ankur Gulati, Sanjay Prasad, Robert M. Graham, Jane McCrohon, Cameron Holloway, Eugene Kotlyar, Kavitha Muthiah, Anne M. Keogh, Christopher S. Hayward, Peter S. Macdonald, Andrew Jabbour
Summary: This study aimed to assess the feasibility of cardiovascular magnetic resonance (CMR)-based myocardial tissue characterization for monitoring acute cardiac allograft rejection (ACAR)-induced myocarditis after heart transplantation. The results showed that CMR-based multiparametric assessment was highly reproducible and reliable, with higher specificity and negative predictive value for detecting ACAR compared to single CMR mapping. Compared to biopsy-based surveillance, CMR-based surveillance strategy could reduce hospitalization and infection rates.
Review
Respiratory System
Shana N. S. Khan, Robert G. Stirling, Catriona A. Mclean, Prudence A. Russell, Ryan F. Hoy
Summary: Pulmonary alveolar proteinosis (PAP) is a rare lung disease characterized by the accumulation of surfactant in the alveoli. It can be classified into primary, secondary, and congenital types based on the underlying cause. We report a case of silicoproteinosis in a stone benchtop fabricator with elevated levels of serum GM-CSF-Ab, which is a key diagnostic feature in autoimmune PAP.
RESPIROLOGY CASE REPORTS
(2022)
Article
Oncology
Michael Cangkrama, Huan Liu, James Whipman, Maria Zubair, Mai Matsushita, Michela Di Filippo, Manfred Kopf, Metello Innocenti, Sabine Werner
Summary: This study reveals the crucial role of mitochondria in the protumorigenic CAF phenotype and identifies the activin A-mDia2-MIRO1 signaling axis as a potential diagnostic and therapeutic target in CAFs.
Review
Oncology
Rajdeep Chakraborty, Charbel Darido, Fei Liu, Maciej Maselko, Shoba Ranganathan
Summary: Immune therapies have shown promising results in the treatment of head and neck cancer by boosting the patient's immune system to fight tumor spread. This review highlights recent clinical success in the field of head and neck cancer immunotherapy, including the development of immune checkpoint inhibitors and a human papilloma virus vaccine. The review also emphasizes the importance of understanding basic biology and implementing personalized immunotherapy for better treatment outcomes.
Review
Cell Biology
Danica Nheu, Olivia Ellen, Sining Ye, Ezgi Ozturk, Maurice Pagnin, Stephen Kertadjaja, Paschalis Theotokis, Nikolaos Grigoriadis, Catriona McLean, Steven Petratos
Summary: Current therapeutics for chronic phases of multiple sclerosis (MS) have limitations in reversing neural damage caused by inflammation and demyelination. Our research suggests that blocking the activation of microglia can be a potential therapeutic strategy to limit neuroinflammation and neurodegeneration in MS. This review explores the role and polarization of microglia in MS pathology, as well as the potential of targeting Nogo-A/NgR cellular mechanisms for neurorepair in MS and other demyelination diseases.
Article
Gastroenterology & Hepatology
Smitha Rose Georgy, Diar Riyanti Rudiatmoko, Alana Auden, Darren Partridge, Tariq Butt, Seema Srivastava, Nick Wong, Dijina Swaroop, Marina Rose Carpinelli, Mirjana Bogeski, Stephen M. Jane
Summary: The transcription factor GRHL3 functions as a tumor suppressor in esophageal squamous cell carcinoma by regulating HOPX expression and Wnt signaling. The study highlights the potential of targeted therapies against the Wnt/beta-catenin pathways in patients with reduced GRHL3 expression.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mateusz S. Wietecha, David Lauenstein, Michael Cangkrama, Sybille Seiler, Juyoung Jin, Andreas Goppelt, Manfred Claassen, Mitchell P. Levesque, Reinhard Dummer, Sabine Werner
Summary: Healing wounds and cancers share similarities at the cellular and molecular levels. The specific roles of healing phases are poorly understood. By comparing gene expression patterns, it was found that a wound signature during the resolution phase is associated with more severe skin cancer. Comparison of early and late-phase wound fibroblasts with cancer-associated fibroblasts (CAFs) identified distinct subtypes of CAFs. These findings provide insights into wound-regulated genes and matrix patterns with prognostic potential in skin cancer.
Article
Dermatology
Mitchell S. Stark, Richard A. Sturm, Yan Pan, Darren J. Smit, Varsha Kommajosyula, Katie J. Lee, Kasturee Jagirdar, Catriona McLean, David L. Duffy, H. Peter Soyer, Victoria J. Mar
Summary: This study performed a rare-variant allele analysis, identifying some genes associated with nodular melanoma (NM), including PTCH1, ARID2, and GHR. Rare variants in the SMO gene, which interacts with PTCH1, were also found, suggesting a potential contribution of the Hedgehog pathway to NM risk.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Biology
Daniel Frank, Maria Bergamasco, Michael J. Mlodzianoski, Andrew Kueh, Ellen Tsui, Cathrine Hall, Georgios Kastrappis, Anne Kathrin Voss, Catriona McLean, Maree Faux, Kelly L. Rogers, Bang Tran, Elizabeth Vincan, David Komander, Grant Dewson, Hoanh Tran
Summary: Mutation in ZRANB1 gene has been found to be associated with various congenital disorders, including reduced brain size. These mutations affect the regulation of neurite growth and result in reduced neuronal and glial cell densities in the brain, as well as motor deficits.
Article
Dermatology
Sasha Hall, Christopher Y. Chew, Tom Kovitwanichkanont, Ken Hiu-Kan Ip, Jennifer Cahill, Alexander Gin, Catriona A. Mclean, Douglas Gin
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2023)
Review
Developmental Biology
Joanne Wong, Jemma Gasperoni, Jarrad Fuller, Sylvia V. H. Grommen, Bert De Groef, Cathryn Hogarth, Sebastian Dworkin
Summary: During embryonic development, organs undergo coiling, bending or folding to establish their final shape and function. This review focuses on examining genetic and molecular factors that contribute to the patterning of coiled structures, with a primary focus on the epididymis as a model organ.
JOURNAL OF DEVELOPMENTAL BIOLOGY
(2022)