Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

AXL Mediates Resistance to PI3Kα Inhibition by Activating the EGFR/PKC/mTOR Axis in Head and Neck and Esophageal Squamous Cell Carcinomas

(2015) Moshe Elkabets et al.   CANCER CELL

TGF-β Promotes Heterogeneity and Drug Resistance in Squamous Cell Carcinoma

(2015) Naoki Oshimori et al.   CELL

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

A Flexible Reporter System for Direct Observation and Isolation of Cancer Stem Cells

(2015) Binwu Tang et al.   Stem Cell Reports

Will PI3K pathway inhibitors be effective as single agents in patients with cancer?

(2015) Joan T. Garrett et al.   Oncotarget

Abstract 4791: Serous cancer progenitor cells in the oviduct.

(2014) Gang Ning et al.   CANCER RESEARCH

SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma

(2014) Soufiane Boumahdi et al.   NATURE

SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma

(2014) Jasmin M. Siegle et al.   Nature Communications

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

(2013) Kevin B. Myant et al.   Cell Stem Cell

Epithelial stem cell mutations that promote squamous cell carcinoma metastasis

(2013) Ruth A. White et al.   JOURNAL OF CLINICAL INVESTIGATION

A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins

(2013) Stephen B. Keysar et al.   Molecular Oncology

Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers

(2013) V. W. Y. Lui et al.   Cancer Discovery

Sox2 Acts through Sox21 to Regulate Transcription in Pluripotent and Differentiated Cells

(2012) Andrey N. Kuzmichev et al.   CURRENT BIOLOGY

EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer

(2012) Sandeep Singh et al.   Molecular Cancer

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative

(2011) A. Biddle et al.   CANCER RESEARCH

E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming

(2011) Torben Redmer et al.   EMBO REPORTS

Cancer stem cells in head and neck squamous cell carcinoma: A review of current knowledge and future applications

(2011) Feriyl Bhaijee et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States

(2011) Anil K. Chaturvedi et al.   JOURNAL OF CLINICAL ONCOLOGY

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors

(2011) A. Chakrabarty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

Activation of the PI3K/AKT signalling pathway in non-melanoma skin cancer is not mediated by oncogenic PIK3CA and AKT1 hotspot mutations

(2010) Christian Hafner et al.   EXPERIMENTAL DERMATOLOGY

Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer

(2009) Yu-Chih Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting cancer stem cells for more effective therapies: Taking out cancer's locomotive engine

(2009) Raymond J. Winquist et al.   BIOCHEMICAL PHARMACOLOGY

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

(2008) D. Hambardzumyan et al.   GENES & DEVELOPMENT

Incidence Trends for Human Papillomavirus–Related and –Unrelated Oral Squamous Cell Carcinomas in the United States

(2008) Anil K. Chaturvedi et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer Stem Cells in Head and Neck Squamous Cell Cancer

(2008) Mark E.P. Prince et al.   JOURNAL OF CLINICAL ONCOLOGY

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE