The role of barrier genes in epidermal malignancy

Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis

(2015) Rong Zhong et al.   CANCER RESEARCH

Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma

(2015) Smitha R. Georgy et al.   JNCI-Journal of the National Cancer Institute

Innate sensing of microbial products promotes wound-induced skin cancer

(2015) Esther Hoste et al.   Nature Communications

Identification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma

(2015) Smitha R. Georgy et al.   JNCI-Journal of the National Cancer Institute

A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia

(2014) William M. Gordon et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Grainy Head-Like 1 Is Associated with Disruption of the Epidermal Barrier and Squamous Cell Carcinoma of the Skin

(2014) Michal Mlacki et al.   PLoS One

Epidermal Differentiation in Barrier Maintenance and Wound Healing

(2014) Tongyu Cao Wikramanayake et al.   Advances in Wound Care

Src is activated by the nuclear receptor peroxisome proliferator-activated receptor β/δ in ultraviolet radiation-induced skin cancer

(2013) Alexandra Montagner et al.   EMBO Molecular Medicine

Stem Cells behind the Barrier

(2013) Michael Cangkrama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Golgi Feels Its Own Wound

(2013) Charbel Darido et al.   Advances in Wound Care

Elevated Epidermal Thymic Stromal Lymphopoietin Levels Establish an Antitumor Environment in the Skin

(2012) Shadmehr Demehri et al.   CANCER CELL

Loss of Cutaneous TSLP-Dependent Immune Responses Skews the Balance of Inflammation from Tumor Protective to Tumor Promoting

(2012) Matteo Di Piazza et al.   CANCER CELL

Deficiency of the Kruppel-like factor KLF4 correlates with increased cell proliferation and enhanced skin tumorigenesis

(2012) Juan Li et al.   CARCINOGENESIS

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Amniotic Fluid Activates the Nrf2/Keap1 Pathway to Repair an Epidermal Barrier Defect In Utero

(2012) Aaron J. Huebner et al.   DEVELOPMENTAL CELL

ZNF750 Is a p63 Target Gene that Induces KLF4 to Drive Terminal Epidermal Differentiation

(2012) George L. Sen et al.   DEVELOPMENTAL CELL

Interferon Regulatory Factor 6 Promotes Differentiation of the Periderm by Activating Expression of Grainyhead-Like 3

(2012) Gabriel de la Garza et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1

(2012) A Bhandari et al.   ONCOGENE

Solar UV radiation reduces the barrier function of human skin

(2012) K. Biniek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial stem cells and implications for wound repair

(2012) Maksim V. Plikus et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Genetic pathways in disorders of epidermal differentiation

(2012) Vanessa Lopez-Pajares et al.   TRENDS IN GENETICS

Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis

(2011) Charbel Darido et al.   CANCER CELL

14-3-3σ and p63 play opposing roles in epidermal tumorigenesis

(2011) Qiutang Li et al.   CARCINOGENESIS

ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization

(2011) M K Leonard et al.   CELL DEATH AND DIFFERENTIATION

IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes

(2011) Gaetana Restivo et al.   EMBO JOURNAL

TCF/Lef1-Mediated Control of Lipid Metabolism Regulates Skin Barrier Function

(2011) Dagmar Fehrenschild et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Role of Chronic Inflammation in Cutaneous Fibrosis: Fibroblast Growth Factor Receptor Deficiency in Keratinocytes as an Example

(2011) Michael Meyer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Adhesion molecule signalling: not always a sticky business

(2011) Ugo Cavallaro et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair

(2011) Sebastian Dworkin et al.   Organogenesis

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1

(2010) C. A. Ambler et al.   DEVELOPMENT

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity

(2010) Yeliz Boglev et al.   DEVELOPMENTAL BIOLOGY

Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway

(2010) Jacinta Caddy et al.   DEVELOPMENTAL CELL

Distinct roles of JNK-1 and ERK-2 isoforms in permeability barrier repair and wound healing

(2010) Kathrin Koehler et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

ABCA12 mutations and autosomal recessive congenital ichthyosis: A review of genotype/phenotype correlations and of pathogenetic conceptsa

(2010) Masashi Akiyama   HUMAN MUTATION

Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis

(2010) Jingxuan Yang et al.   JOURNAL OF CELL BIOLOGY

Adherens junctions: from molecules to morphogenesis

(2010) Tony J. C. Harris et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin

(2010) Alexis Dumortier et al.   PLoS One

Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate

(2010) E. N. Arwert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidermal Notch1 Loss Promotes Skin Tumorigenesis by Impacting the Stromal Microenvironment

(2009) Shadmehr Demehri et al.   CANCER CELL

IFN  Promotes Papilloma Development by Up-regulating Th17-Associated Inflammation

(2009) M. Xiao et al.   CANCER RESEARCH

Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction

(2009) E. A. Leclerc et al.   JOURNAL OF CELL SCIENCE

PPARδ Activation Promotes Stratum Corneum Formation and Epidermal Permeability Barrier Development during Late Gestation

(2009) Yan J. Jiang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications

(2009) Erika L Abel et al.   Nature Protocols

IKKα Is Required to Maintain Skin Homeostasis and Prevent Skin Cancer

(2008) Bigang Liu et al.   CANCER CELL

Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells

(2008) C. Darido et al.   CANCER RESEARCH

IKKα, a critical regulator of epidermal differentiation and a suppressor of skin cancer

(2008) Pascal Descargues et al.   EMBO JOURNAL

Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of  -catenin in mice

(2008) T. Grigoryan et al.   GENES & DEVELOPMENT

ABCA12 Maintains the Epidermal Lipid Permeability Barrier by Facilitating Formation of Ceramide Linoleic Esters

(2008) Ying Zuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis

(2008) Xuan Wang et al.   JOURNAL OF CELL BIOLOGY

Cyclin D1 downregulation is important for permanent cell cycle exit and initiation of differentiation induced by anchorage-deprivation in human keratinocytes

(2008) Kayoko Nishi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cancer as an overhealing wound: an old hypothesis revisited

(2008) Matthias Schäfer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrity

(2008) C. L. Tinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of p120 catenin and links to mitotic alterations, inflammation, and skin cancer

(2008) M. Perez-Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity

(2008) Shadmehr Demehri et al.   PLOS BIOLOGY

Characterization of a Hapten-Induced, Murine Model with Multiple Features of Atopic Dermatitis: Structural, Immunologic, and Biochemical Changes following Single Versus Multiple Oxazolone Challenges

(2007) Mao-Qiang Man et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY