Article
Biochemistry & Molecular Biology
Ethan L. L. Morgan, Tiffany Toni, Ramya Viswanathan, Yvette Robbins, Xinping Yang, Hui Cheng, Sreenivasulu Gunti, Angel Huynh, Anastasia L. L. Sowers, James B. B. Mitchell, Clint T. T. Allen, Zhong Chen, Carter Van Waes
Summary: TNF alpha is a key mediator of immune, chemotherapy and radiotherapy-induced cytotoxicity, but several cancers display resistance to TNF alpha due to activation of the NF kappa B pro-survival pathway. In this study, we found that the expression of USP14, a proteasome-associated deubiquitinase, is increased in HNSCC and correlates with worse progression free survival. Inhibition or depletion of USP14 inhibited the proliferation and survival of HNSCC cells and reduced NF kappa B activity. Furthermore, we showed that the inhibitor b-AP15 sensitized HNSCC cells to TNF alpha-mediated cell death and radiation-induced cell death, and delayed tumor growth in vivo.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yanting Wang, Xianyue Ren, Weiyu Li, Ruoyan Cao, Suyang Liu, Laibo Jiang, Bin Cheng, Juan Xia
Summary: SPDEF acts as a tumor suppressor in HNSCC by transcriptionally activating NR4A1, leading to inhibition of AKT, MAPK, and NF-kappa B signaling pathways. Low expression of SPDEF is associated with poor clinical outcomes in HNSCC patients, and restoration of SPDEF inhibits cell proliferation in HNSCC.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Danni Li, Xuran Li, Jun Zhao, Fei Tan
Summary: Molecular imaging has the potential to play a role in the diagnosis of head and neck squamous cell carcinoma, and early tumor identification can help with treatment. Targeted therapy has already been proven effective in some cases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Xin Zhou, Xiaoshen Wang
Summary: This review provides a detailed illustration of the biology, genomic features, and immune landscapes of HPV-associated HNSCC, supporting the synergistic effect of radioimmunotherapy. Current evidence and ongoing clinical trials suggest the potential of radioimmunotherapy in recurrent/metastatic or definitive settings. Future challenges include optimization of radiotherapy and the incorporation of novel therapeutic options.
Article
Oncology
Hongming Wang, Fei Wang, Wenyu Ouyang, Xuejun Jiang, Yan Wang
Summary: BCAT1 is overexpressed in head and neck squamous cell carcinoma, and is associated with tumor progression and poor patient survival. It plays a role in regulating cell proliferation, invasion, chemotherapy sensitivity, and metabolic pathways.
Article
Endocrinology & Metabolism
Yu Liu, Nana Liu, Xue Zhou, Lingqiong Zhao, Wei Wei, Jie Hu, Zhibin Luo
Summary: This study identified key genes related to glucose metabolism in HNSC and discovered five prognosis-related genes. A nomogram incorporating age, lymph node status, and risk score was constructed for survival prediction in HNSC patients, emphasizing the crucial role of GMRGs in HNSC.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Jiantong Bao, Annika C. Betzler, Jochen Hess, Cornelia Brunner
Summary: Distinct B cell subpopulations in the tumor milieu of head and neck squamous cell carcinoma (HNSCC) exert either pro- or anti-tumor activities. Certain B cell subsets in the tumor microenvironment exhibit immunosuppressive function, while B cells within tertiary lymphoid structures predominantly play anti-tumor effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Vaishali Chandel, Saurabh Maru, Arun Kumar, Ashok Kumar, Ashok Sharma, Brijesh Rathi, Dhruv Kumar
Summary: Head and Neck tumors exhibit highly altered metabolism, with cancer cells utilizing different pathways for energy production. Monocarboxylate transporters play a crucial role in regulating lactate and maintaining pH balance, essential for cancer cell survival and growth control.
Article
Biochemistry & Molecular Biology
Mengmeng Li, Qinglai Tang, Shisheng Li, Xinming Yang, Ying Zhang, Xiaojun Tang, Peiying Huang, Danhui Yin
Summary: The study found that Schisandrin B (Sch B) exerts anticancer effects on head and neck squamous cell carcinoma (HNSCC) by regulating apoptosis and autophagy. Sch B can induce apoptosis and autophagy in HNSCC cells, and inhibition of autophagy can enhance the apoptotic effect of Sch B. Additionally, Sch B-activated autophagy in HNSCC cells is dependent on the nuclear factor-kappa B (NF-kappa B) pathway, and reactive oxygen species (ROS) act as a regulator of the NF-B pathway. Therefore, inhibiting autophagy to enhance the anticancer effect of Sch B deserves further research.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ching-Yun Hsieh, Ching-Chan Lin, Wei-Chao Chang
Summary: Taxanes, especially docetaxel, are widely used in combination therapy for head and neck squamous cell carcinoma (HNSCC) and have shown advantages in improving patient outcomes. Taxanes not only function as antimitotics, but also impair various oncogenic signaling pathways. However, the development of drug resistance remains a major obstacle to treatment response.
Review
Biochemistry & Molecular Biology
Shengjian Jin, Yasusei Kudo, Taigo Horiguchi
Summary: Ubiquitination and deubiquitination are two common post-translational modifications of proteins, affecting their intracellular localization, stability, and function. Deubiquitination is involved in various cellular processes, including histone modification, cell cycle regulation, apoptosis, and cancer development. This review focuses on the understanding of the function of deubiquitinating enzymes in head and neck squamous cell carcinoma (HNSCC) and discusses potential therapeutic strategies for HNSCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Chenhang Yu, Qiang Li, Yu Zhang, Zhi-Fa Wen, Heng Dong, Yongbin Mou
Summary: Head and neck squamous cell carcinoma (HNSCC) has a high incidence and mortality rate. Immunotherapy, with its potential for a broad and long-lasting antitumor response, has become an important therapeutic strategy for HNSCC. However, immune escape limits the effectiveness of immunotherapy. Various immunotherapy strategies, including immune checkpoint inhibitors, costimulatory agonists, antigenic vaccines, oncolytic virus therapy, adoptive T cell transfer, and targeted therapy, have been developed for HNSCC. Each strategy has its unique advantages, and their appropriate application has significant value for the treatment of HNSCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Kamila Romanowska, Agnieszka Sobecka, Agnieszka A. Rawluszko-Wieczorek, Wiktoria M. Suchorska, Wojciech Golusinski
Summary: Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with molecular pathogenesis involving cell cycle disorders, intercellular signaling, proliferation, squamous cell differentiation, and apoptosis. In addition to genetic mutations, epigenetic alterations such as DNA methylation and histone modifications play a key role in promoting cancer formation and progression, making them potential biomarkers and therapeutic targets for HNSCC.
Article
Oncology
Charlotte Koetting, Linda Hofmann, Ramin Lotfi, Daphne Engelhardt, Simon Laban, Patrick J. Schuler, Thomas K. Hoffmann, Cornelia Brunner, Marie-Nicole Theodoraki
Summary: Curcumin modulates the immune response and has anti-tumor effects by inhibiting NF-kappa B activation and reducing regulatory T-cell attraction, making it a promising adjuvant in cancer therapy for head and neck squamous cell carcinoma.