Cancer cells’ ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential

Characterization of the mechanical properties of cancer cells in 3D matrices in response to collagen concentration and cytoskeletal inhibitors

(2018) Jessica E. Kim et al.   Integrative Biology

Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling

(2018) Benjamin L Ricca et al.   eLife

Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood

(2018) Nicole Toepfner et al.   eLife

Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix

(2017) Armen H. Mekhdjian et al.   MOLECULAR BIOLOGY OF THE CELL

Numerical Simulation of Real-Time Deformability Cytometry To Extract Cell Mechanical Properties

(2017) M. Mokbel et al.   ACS Biomaterials-Science & Engineering

Numerical Simulation of Real-Time Deformability Cytometry To Extract Cell Mechanical Properties

(2017) M. Mokbel et al.   ACS Biomaterials Science & Engineering

Focal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices

(2017) Claudia T. Mierke et al.   Scientific Reports

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

Extracting Cell Stiffness from Real-Time Deformability Cytometry: Theory and Experiment

(2015) Alexander Mietke et al.   BIOPHYSICAL JOURNAL

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

(2015) C. D. Madsen et al.   EMBO REPORTS

A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype

(2015) Luke Cassereau et al.   JOURNAL OF BIOTECHNOLOGY

Real-time deformability cytometry: on-the-fly cell mechanical phenotyping

(2015) Oliver Otto et al.   NATURE METHODS

Targeting ECM Disrupts Cancer Progression

(2015) Freja A. Venning et al.   Frontiers in Oncology

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Crosstalk elimination in the detection of dual-beam optical tweezers by spatial filtering

(2014) Dino Ott et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling

(2014) Y. H. Bae et al.   Science Signaling

Review of Collagen I Hydrogels for Bioengineered Tissue Microenvironments: Characterization of Mechanics, Structure, and Transport

(2014) Elizabeth E. Antoine et al.   TISSUE ENGINEERING PART B-REVIEWS

Diffusion inside living human cells

(2012) N. Leijnse et al.   European Physical Journal-Special Topics

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK

(2012) A-M Baker et al.   ONCOGENE

3D Traction Forces in Cancer Cell Invasion

(2012) Thorsten M. Koch et al.   PLoS One

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

(2011) Matthew W. Conklin et al.   AMERICAN JOURNAL OF PATHOLOGY

Mechanical Stiffness Grades Metastatic Potential in Patient Tumor Cells and in Cancer Cell Lines

(2011) V. Swaminathan et al.   CANCER RESEARCH

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices

(2010) Miguel Miron-Mendoza et al.   BIOMATERIALS

Cancer Cell Stiffness: Integrated Roles of Three-Dimensional Matrix Stiffness and Transforming Potential

(2010) Erin L. Baker et al.   BIOPHYSICAL JOURNAL

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

(2010) P. Schedin et al.   Cold Spring Harbor Perspectives in Biology

Probing cellular mechanobiology in three-dimensional culture with collagen–agarose matrices

(2009) Theresa A. Ulrich et al.   BIOMATERIALS

Extracellular Matrix Stiffness and Architecture Govern Intracellular Rheology in Cancer

(2009) Erin L. Baker et al.   BIOPHYSICAL JOURNAL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin

(2009) Aurélien Bancaud et al.   EMBO JOURNAL

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer

(2008) Paolo P. Provenzano et al.   AMERICAN JOURNAL OF PATHOLOGY

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Three-dimensional context regulation of metastasis

(2008) Janine T. Erler et al.   CLINICAL & EXPERIMENTAL METASTASIS