Article
Oncology
Thomas K. Sears, Kevin D. Woolard
Summary: This study revealed that high expression of BRD4 is associated with decreased survival in glioma patients carrying IDHmut. Gliomas with IDHmut show increased sensitivity to the BET inhibitor JQ1, especially in terms of delayed cytotoxicity. Epigenetic-targeting drugs may serve as effective therapeutic strategies for IDHmut gliomas.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Zhuo Yang, Nan Hu, Weiwei Wang, Weihua Hu, Shaolong Zhou, Jianxiang Shi, Minghe Li, Zhou Jing, Chao Chen, Xuyang Zhang, Ruyi Yang, Xudong Fu, Xinjun Wang
Summary: The lack of FBXW7 results in DNA repair defects and disruption of NADPH homeostasis in IDH1-mutant glioma cells, making them highly susceptible to radiotherapy.
Article
Biotechnology & Applied Microbiology
Xin Ouyang, Zhimei He, Heng Fang, Huidan Zhang, Qi Yin, Linhui Hu, Fei Gao, Hao Yin, Taofang Hao, Yating Hou, Qingrui Wu, Jia Deng, Jing Xu, Yirong Wang, Chunbo Chen
Summary: This study revealed the crucial role of circular RNAs (circRNAs) in the regulation of autophagy in ischemic acute kidney injury (AKI). Specifically, circ-ZNF609, which is highly expressed in the kidney after ischemia/reperfusion injury, was found to activate AKT3/mTOR signaling and induce autophagy flux impairment and cell apoptosis. Mechanistically, circ-ZNF609 encodes a functional protein called ZNF609-250aa, which also promotes autophagy flux impairment and cell apoptosis. Targeting circ-ZNF609 may provide a novel therapy for ischemic AKI.
Article
Nutrition & Dietetics
Tzu-Shao Yeh, Tze-Huan Lei, Jen-Fang Liu, Mei-Chich Hsu
Summary: Astragalus membranaceus (AM) is a high-class traditional herbal medicine known for its vitality-enhancing and multifunctional pharmacological activities. This study found that AM promotes skeletal muscle hypertrophy by activating the PI3K/Akt/mTOR signaling pathway, potentially serving as a promising aid in preventing muscle wasting.
Article
Cell Biology
Yi Zhu, Ling Zuo, Hong Xiong, Shihao Li, Ruiqi Chen, Hongwei Liu
Summary: In this study, circHGS was found to be upregulated in bladder cancer and positively associated with tumor grade and pathological T stage. Silencing of circHGS inhibited cell cycle, proliferation, migration and invasion, while its overexpression had the opposite effect. Mechanistically, circHGS acted as a sponge of miR-513a-5p to increase VEGFC expression and activate the AKT/mTOR pathway, ultimately promoting bladder cancer progression. These findings suggest that circHGS may serve as a promising therapeutic target for bladder cancer.
Article
Cell Biology
Ming Xu, Xianglan Zhang, Songnan Zhang, Junjie Piao, Yang Yang, Xinyue Wang, Zhenhua Lin
Summary: SPOCK1 plays a crucial role in breast cancer progression by promoting cell proliferation and metastasis, making it a promising clinical therapeutic target for preventing the progression of breast cancer.
Article
Medicine, Research & Experimental
Hui Gong, Xing Lyu, Yang Liu, Naling Peng, Shengyu Tan, Lini Dong, Xiangyu Zhang
Summary: Eupatilin alleviates pulmonary fibrosis through the Sestrin2/PI3K/Akt/mTOR-dependent autophagy pathway, reducing the expression of fibrotic markers. This study provides a new insight and potential drug target for the treatment of IPF.
Article
Medicine, Research & Experimental
Zhangya Pu, Dan G. Duda, Yuanyuan Zhu, Siya Pei, Xiaofang Wang, Yan Huang, Panpan Yi, Zebing Huang, Fang Peng, Xingwang Hu, Xuegong Fan
Summary: This study found that VCP is significantly increased in HCC tissues and is associated with advanced TNM stages and poorer prognosis. VCP overexpression promotes HCC cell proliferation, migration, and invasion via PI3K/AKT/mTOR pathway activation. Additionally, VCP interacts with HMGB1 and enhances its protein stability, contributing to HCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dandan Wang, Xiaoying Jin, Mengxia Lei, Ying Jiang, Yali Liu, Fei Yu, Yan Guo, Bing Han, Yue Yang, Weiling Sun, Ying Liu, Guangchun Zeng, Feng Liu, Jing Hu, Xuesong Chen
Summary: This study discovers that angiotensin II type 1 receptor-associated protein is highly expressed in breast cancer tissues and promotes aggressiveness by promoting cell growth, metastasis, and aerobic glycolysis. It also plays a crucial role in regulating the deubiquitination and stabilization of Pre-B cell leukemia homeobox 3 through ubiquitin-specific protease 14. Furthermore, it is identified as a direct target of upstream stimulatory factor 1 and its overexpression can reverse the inhibitory effects of upstream stimulatory factor 1 knockdown.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Wei Lei, Yiqi Yan, Yaolei Ma, Min Jiang, Boli Zhang, Han Zhang, Yuhong Li
Summary: This study investigated the cardioprotective mechanism of notoginsenoside R1 (NGR1) in improving ischemic heart diseases. The results showed that NGR1 improved echocardiographic, tissue pathological, and serum biochemical perturbations in myocardial ischemic rats. Network pharmacology studies indicated that NGR1 mainly regulated smooth muscle cell proliferation, vasculature development, and lipid metabolism signaling. Myocardial proteomics revealed that NGR1 focused on regulating metabolic and energy supply processes. The study demonstrated that NGR1 modulated lipid metabolism in ischemic myocardia by interacting with mTOR and AKT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hui Liu, Xi Li, Jingui Lin, Miaokuo Lin
Summary: Morroniside exerts a proosteogenic effect by promoting PI3K/Akt/mTOR signaling, providing a novel clue for the treatment of osteoporosis.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Cell Biology
Liqun Yang, Zhigang Dong, Shuyu Li, Tieliang Chen
Summary: This study aimed to explore the influence of endothelial cell-specific molecule 1 (ESM1) expression on colorectal cancer (CRC) cells and analyze its possible mechanism. ESM1 overexpression was found to promote tumor angiogenesis in CRC and accelerate tumor progression. The study also revealed that ESM1 may promote angiogenesis in CRC by activating the PI3K/Akt/mTOR pathway.
Article
Medicine, Research & Experimental
Rattanaporn Jaidee, Veerapol Kukongviriyapan, Laddawan Senggunprai, Auemduan Prawan, Apinya Jusakul, Phatthamon Laphanuwat, Sarinya Kongpetch
Summary: Knockdown of FGFR2 suppressed cell growth and colony formation in CCA cells through G2/M cell cycle arrest and downregulation of STAT3, cyclin A, and cyclin B1. Silencing FGFR2 enhanced the suppressive effect of gemcitabine on cell migration and invasion.
Article
Medicine, General & Internal
Peng Du, Kaifeng Luo, Guoyong Li, Jisheng Zhu, Qi Xiao, Yong Li, Xingjian Zhang
Summary: The study revealed that PRMT4 is highly expressed in HCC and closely associated with clinical characteristics and prognosis of liver cancer. PRMT4 promotes proliferation, migration, and invasion of HCC cells by activating the AKT/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Cell Biology
Yan Li, Yongying Zhou, Mingliu Huang, Zhen Wang, Daoquan Liu, Jianmin Liu, Xun Fu, Shu Yang, Shidong Shan, Liang Yang, Yuhang Guo, Pengfei Ren, Ping Chen, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E. DiSanto, Xinhua Zhang
Summary: This study found that 7-dehydrocholesterol reductase (DHCR7) is upregulated in bladder cancer (BCa) and is associated with tumor grade and stage, resulting in poor prognosis. Further investigation revealed that DHCR7 overexpression promotes tumor cell proliferation, inhibits apoptosis, enhances invasion and migration, and induces epithelial-mesenchymal transition (EMT) through the PI3K/AKT/mTOR signaling pathway in vitro and in vivo. DHCR7 deficiency significantly decreases tumorigenesis. These findings suggest that DHCR7 may serve as a potential molecular target for the diagnosis and treatment of BCa.
CELLULAR SIGNALLING
(2023)