STIM-Orai Channels and Reactive Oxygen Species in the Tumor Microenvironment

ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses

(2019) Iman Azimi et al.   Cancers

Mechanisms and Applications of Redox-Sensitive Green Fluorescent Protein-Based Hydrogen Peroxide Probes

(2018) Leticia Prates Roma et al.   ANTIOXIDANTS & REDOX SIGNALING

Electron Paramagnetic Resonance Measurements of Reactive Oxygen Species by Cyclic Hydroxylamine Spin Probes

(2018) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

In Vivo and In Situ Detection of Macromolecular Free Radicals Using Immuno-Spin Trapping and Molecular Magnetic Resonance Imaging

(2018) Rheal A. Towner et al.   ANTIOXIDANTS & REDOX SIGNALING

Electrochemical Quantification of Extracellular Local H2O2 Kinetics Originating from Single Cells

(2018) Monika Bozem et al.   ANTIOXIDANTS & REDOX SIGNALING

Orai1 is critical for Notch-driven aggressiveness under hypoxic conditions in triple-negative breast cancers

(2018) Xiaoyu Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hypoxia-induced upregulation of Orai1 drives colon cancer invasiveness and angiogenesis

(2018) Xiaoyu Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Selective inhibitory effects of zinc on cell proliferation in esophageal squamous cell carcinoma through Orai1

(2018) Sangyong Choi et al.   FASEB JOURNAL

Small-molecule luminescent probes for the detection of cellular oxidizing and nitrating species

(2018) Jacek Zielonka et al.   FREE RADICAL BIOLOGY AND MEDICINE

The store-operated calcium channels in cancer metastasis from cell migration invasion to metastatic colonization

(2018) Shengyu Yang   Frontiers in Bioscience-Landmark

Impact of tumor microenvironment composition on therapeutic responses and clinical outcomes in cancer

(2018) Fern Anari et al.   Future Oncology

A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity

(2018) Xiao Zhou et al.   JOURNAL OF PHYSIOLOGY-LONDON

Redox control in cancer development and progression

(2018) Valeska Helfinger et al.   MOLECULAR ASPECTS OF MEDICINE

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Store operated calcium entry is altered by the inhibition of receptors tyrosine kinase

(2018) Noémie Emeriau et al.   Oncotarget

The calcium channel proteins ORAI3 and STIM1 mediate TGF-β induced Snai1 expression

(2018) Atrayee Bhattacharya et al.   Oncotarget

STIM2 Induces Activated Conformation of STIM1 to Control Orai1 Function in ER-PM Junctions

(2018) Krishna Prasad Subedi et al.   Cell Reports

The Epithelial-to-Mesenchymal Transition in Cancer

(2018) Joëlle Roche   Cancers

ORAI channels and cancer

(2018) Silke B. Chalmers et al.   CELL CALCIUM

Regulation of proto-oncogene Orai3 by miR18a/b and miR34a

(2018) Ayushi Vashisht et al.   CELL CALCIUM

Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification and modulation of apoptosis, necrosis and mixed forms

(2018) Christian S Backes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minimal functional driver gene heterogeneity among untreated metastases

(2018) Johannes G. Reiter et al.   SCIENCE

Silencing Heat Shock Protein 27 Inhibits the Progression and Metastasis of Colorectal Cancer (CRC) by Maintaining the Stability of Stromal Interaction Molecule 1 (STIM1) Proteins

(2018) Chien-Yu Huang et al.   Cells

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hemophagocytic lymphohistiocytosis as presenting manifestation of profound combined immunodeficiency due to an ORAI1 mutation

(2017) Christian Klemann et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulation of redox balance in cancer and T cells

(2017) Hyewon Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

sp2 -Iminosugar α-glucosidase inhibitor 1-C -octyl-2-oxa-3-oxocastanospermine specifically affected breast cancer cell migration through Stim1, β1-integrin, and FAK signaling pathways

(2017) Nahla Gueder et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Reperfusion strategies in acute myocardial infarction and multivessel disease

(2017) Birgit Vogel et al.   Nature Reviews Cardiology

Suppression of STIM1 inhibits the migration and invasion of human prostate cancer cells and is associated with PI3K/Akt signaling inactivation

(2017) Yibin Zhou et al.   ONCOLOGY REPORTS

Blocking of stromal interaction molecule 1 expression influence cell proliferation and promote cell apoptosis in vitro and inhibit tumor growth in vivo in head and neck squamous cell carcinoma

(2017) Ping Li et al.   PLoS One

STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion

(2017) Yun-Wen Chen et al.   Scientific Reports

HyPer Family Probes: State of the Art

(2016) Dmitry S. Bilan et al.   ANTIOXIDANTS & REDOX SIGNALING

CRAC channels, calcium, and cancer in light of the driver and passenger concept

(2016) Markus Hoth   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cycling hypoxia: A key feature of the tumor microenvironment

(2016) Carine Michiels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer

(2016) Jianling Xia et al.   CANCER LETTERS

Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor Upregulation

(2016) Sophie Bernichtein et al.   CANCER RESEARCH

Hypoxia in tissue repair and fibrosis

(2016) Ian A. Darby et al.   CELL AND TISSUE RESEARCH

Imaging calcium and redox signals using genetically encoded fluorescent indicators

(2016) Christine S. Gibhardt et al.   CELL CALCIUM

Breast cancer stem cell: the roles and therapeutic implications

(2016) Fang Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System

(2016) Kathy K. Griendling et al.   CIRCULATION RESEARCH

High Expression of Orai1 Enhances Cell Proliferation and is Associated with Poor Prognosis in Human Colorectal Cancer

(2016) Lin Gui et al.   Clinical Laboratory

NOX-driven ROS formation in cell transformation of FLT3-ITD-positive AML

(2016) Ashok Kumar Jayavelu et al.   EXPERIMENTAL HEMATOLOGY

Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling

(2016) Martin D. Brand   FREE RADICAL BIOLOGY AND MEDICINE

Roles for E-cadherin cell surface regulation in cancer

(2016) Yuliya I. Petrova et al.   MOLECULAR BIOLOGY OF THE CELL

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

(2016) Inmaculada Martínez-Reyes et al.   MOLECULAR CELL

The ever-expanding role of HIF in tumour and stromal biology

(2016) Edward L. LaGory et al.   NATURE CELL BIOLOGY

The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination

(2016) E Crosas-Molist et al.   ONCOGENE

Cross Talk Mechanism among EMT, ROS, and Histone Acetylation in Phorbol Ester-Treated Human Breast Cancer MCF-7 Cells

(2016) Tetsuro Kamiya et al.   Oxidative Medicine and Cellular Longevity

Evaluating the evaluation of cancer driver genes

(2016) Collin J. Tokheim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse redox histology using genetically encoded probes

(2016) Yuuta Fujikawa et al.   Science Signaling

A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+channels

(2016) Stephanie Saul et al.   Science Signaling

FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma

(2016) Lisha Qi et al.   Oncotarget

SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline

(2016) Maxime Guéguinou et al.   Oncotarget

Orai3 is a predictive marker of metastasis and survival in resectable lung adenocarcinoma

(2016) Nazim Benzerdjeb et al.   Oncotarget

Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability

(2016) Tim Ting-Chung Yen et al.   Oncotarget

Mouse redox histology using genetically encoded probes

(2016) Yuuta Fujikawa et al.   Science Signaling

A calcium-redox feedback loop controls human monocyte immune responses: The role of ORAI Ca2+channels

(2016) Stephanie Saul et al.   Science Signaling

Imaging free radicals in organelles, cells, tissue, and in vivo with immuno-spin trapping

(2016) Ronald Paul Mason   Redox Biology

Thiol dependent intramolecular locking of Orai1 channels

(2016) Dalia Alansary et al.   Scientific Reports

STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis

(2015) Ayushi Vashisht et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Resveratrol nanoformulation for cancer prevention and therapy

(2015) Imtiaz A. Siddiqui et al.   Annals of the New York Academy of Sciences

Differential Redox Regulation of Ca2+ Signaling and Viability in Normal and Malignant Prostate Cells

(2015) Christian Holzmann et al.   BIOPHYSICAL JOURNAL

ROS-Mediated DNA Methylation Pattern Alterations in Carcinogenesis

(2015) Qihan Wu et al.   CURRENT DRUG TARGETS

Metabolic reprogramming of the tumour microenvironment

(2015) Yazhi Xing et al.   FEBS Journal

Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels

(2015) Anshul Rana et al.   JOURNAL OF CELL BIOLOGY

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Path to Cancer — Three Strikes and You're Out

(2015) Bert Vogelstein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Toward selective detection of reactive oxygen and nitrogen species with the use of fluorogenic probes – Limitations, progress, and perspectives

(2015) Karolina Debowska et al.   Pharmacological Reports

Antioxidants can increase melanoma metastasis in mice

(2015) Kristell Le Gal et al.   Science Translational Medicine

Reactive oxygen species and p21Waf1/Cip1 are both essential for p53-mediated senescence of head and neck cancer cells

(2015) A L Fitzgerald et al.   Cell Death & Disease

A STIM2 splice variant negatively regulates store-operated calcium entry

(2015) Anna-Maria Miederer et al.   Nature Communications

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

(2015) Yandong Zhou et al.   Nature Communications

STIM1 accelerates cell senescence in a remodeled microenvironment but enhances the epithelial-to-mesenchymal transition in prostate cancer

(2015) Yingxi Xu et al.   Scientific Reports

STIM1 Mediates Hypoxia-Driven Hepatocarcinogenesis via Interaction with HIF-1

(2015) Yongsheng Li et al.   Cell Reports

Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?

(2015) Agnes Görlach et al.   Redox Biology

MMP7 Is Required to Mediate Cell Invasion and Tumor Formation upon Plakophilin3 Loss

(2015) Srikanta Basu et al.   PLoS One

ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer

(2015) Christian Holzmann et al.   Oncotarget

Elevated Orai1 expression mediates tumor-promoting intracellular Ca2+ oscillations in human esophageal squamous cell carcinoma

(2015) Hua Zhu et al.   Oncotarget

Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma

(2014) Ji-Hee Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53 and mitochondrial function in neurons

(2014) David B. Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma

(2014) Kateryna Kondratska et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Genetically encoded reactive oxygen species (ROS) and redox indicators

(2014) Sandrine Pouvreau   Biotechnology Journal

Remodeling of Channel-Forming ORAI Proteins Determines an Oncogenic Switch in Prostate Cancer

(2014) Charlotte Dubois et al.   CANCER CELL

A Reciprocal Shift in Transient Receptor Potential Channel 1 (TRPC1) and Stromal Interaction Molecule 2 (STIM2) Contributes to Ca2+Remodeling and Cancer Hallmarks in Colorectal Carcinoma Cells

(2014) Diego Sobradillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1- and Orai1-mediated Ca2+oscillation orchestrates invadopodium formation and melanoma invasion

(2014) Jianwei Sun et al.   JOURNAL OF CELL BIOLOGY

Store-operated Ca 2+ entry regulates glioma cell migration and invasion via modulation of Pyk2 phosphorylation

(2014) Meng Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer

(2014) Z Zhang et al.   ONCOGENE

STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression

(2014) J-Y Wang et al.   ONCOGENE

Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry

(2014) Hedwig Stanisz et al.   Pigment Cell & Melanoma Research

Only three driver gene mutations are required for the development of lung and colorectal cancers

(2014) Cristian Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

(2014) Xizhuo Wang et al.   Nature Communications

Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide

(2014) Yulia G. Ermakova et al.   Nature Communications

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

STIM2 Contributes to Enhanced Store-Operated Ca2+ Entry in Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension

(2014) Michael Y. Song et al.   Pulmonary Circulation

Immuno-spin trapping from biochemistry to medicine: Advances, challenges, and pitfalls. Focus on protein-centered radicals

(2013) Sandra E. Gomez-Mejiba et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Pivotal Role of the Lipid Raft SK3-Orai1 Complex in Human Cancer Cell Migration and Bone Metastases

(2013) A. Chantome et al.   CANCER RESEARCH

Emerging roles of store-operated Ca2+entry through STIM and ORAI proteins in immunity, hemostasis and cancer

(2013) Wolfgang Bergmeier et al.   Channels

Reactive Oxygen Species Induce Epigenetic Instability through the Formation of 8-Hydroxydeoxyguanosine in Human Hepatocarcinogenesis

(2013) Naoshi Nishida et al.   DIGESTIVE DISEASES

The apoptosis of non-small cell lung cancer induced by cisplatin through modulation of STIM1

(2013) Wenjun Li et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

The ER Ca2+ sensor STIM1 regulates actomyosin contractility of migratory cells

(2013) Y.-T. Chen et al.   JOURNAL OF CELL SCIENCE

Suppression of STIM1 inhibits human glioblastoma cell proliferation and induces G0/G1 phase arrest

(2013) Guilin Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Orai3 Constitutes a Native Store-Operated Calcium Entry That Regulates Non Small Cell Lung Adenocarcinoma Cell Proliferation

(2013) Anne-Sophie Ay et al.   PLoS One

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

HyPer-3: A Genetically Encoded H2O2 Probe with Improved Performance for Ratiometric and Fluorescence Lifetime Imaging

(2012) Dmitry S. Bilan et al.   ACS Chemical Biology

Methods for Detection of Mitochondrial and Cellular Reactive Oxygen Species

(2012) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

ORAI3 silencing alters cell proliferation and cell cycle progression via c-myc pathway in breast cancer cells

(2012) Malika Faouzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Calcium, cancer and killing: The role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells

(2012) Eva C. Schwarz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Blockade of store-operated Ca2+ entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover

(2012) Ning Yang et al.   CANCER LETTERS

Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

(2012) Nuno Raimundo et al.   CELL

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Orai3 is an estrogen receptor α-regulated Ca2+ channel that promotes tumorigenesis

(2012) Rajender K. Motiani et al.   FASEB JOURNAL

Dimerumic Acid Inhibits SW620 Cell Invasion by Attenuating H2O2-Mediated MMP-7 Expression via JNK/C-Jun and ERK/C-Fos Activation in an AP-1-Dependent Manner

(2012) Bing-Ying Ho et al.   International Journal of Biological Sciences

DNA damage by reactive species: Mechanisms, mutation and repair

(2012) N R Jena   JOURNAL OF BIOSCIENCES

mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development

(2012) H Peng et al.   ONCOGENE

Role of Ion Channels and Transporters in Cell Migration

(2012) Albrecht Schwab et al.   PHYSIOLOGICAL REVIEWS

Nanoelectrodes for determination of reactive oxygen and nitrogen species inside murine macrophages

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells

(2011) Jiajia Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Requirement for store-operated calcium entry in sodium butyrate-induced apoptosis in human colon cancer cells

(2011) Suxia Sun et al.   BIOSCIENCE REPORTS

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Modulation of STIM1 and capacitative Ca2+ entry by the endoplasmic reticulum luminal oxidoreductase ERp57

(2011) Daniel Prins et al.   EMBO REPORTS

NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

(2011) Wenhao Cui et al.   HEPATOLOGY

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transcription Factor NF-κB Regulates Expression of Pore-forming Ca2+Channel Unit, Orai1, and Its Activator, STIM1, to Control Ca2+Entry and Affect Cellular Functions

(2011) Anja Eylenstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+release

(2011) Basile Darbellay et al.   JOURNAL OF CELL BIOLOGY

Microtubule remodelling is required for the front-rear polarity switch during contact inhibition of locomotion

(2011) S. Kadir et al.   JOURNAL OF CELL SCIENCE

ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer

(2011) D. McAndrew et al.   MOLECULAR CANCER THERAPEUTICS

Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype

(2011) Alvaro Aytes et al.   MOLECULAR CARCINOGENESIS

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

Stoichiometric requirements for trapping and gating of Ca2+release-activated Ca2+(CRAC) channels by stromal interaction molecule 1 (STIM1)

(2011) Paul J. Hoover et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis

(2011) A. Maul-Pavicic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis

(2011) Y.-F. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The tumor microenvironment

(2011) Cynthia E. Weber et al.   SURGICAL ONCOLOGY-OXFORD

Oxidative stress and oxidative damage in chemical carcinogenesis

(2011) James E. Klaunig et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fluorescent Protein-Based Redox Probes

(2010) Andreas J. Meyer et al.   ANTIOXIDANTS & REDOX SIGNALING

Store-Independent Activation of Orai1 by SPCA2 in Mammary Tumors

(2010) Mingye Feng et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits

(2010) Zhengzheng Li et al.   CELL RESEARCH

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

A Novel Native Store-operated Calcium Channel Encoded by Orai3

(2010) Rajender K. Motiani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-glutathionylation activates STIM1 and alters mitochondrial homeostasis

(2010) Brian J. Hawkins et al.   JOURNAL OF CELL BIOLOGY

Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells

(2010) Malika Faouzi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling

(2010) I. Bogeski et al.   Science Signaling

Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells

(2010) M Flourakis et al.   Cell Death & Disease

Molecular Mechanisms of Mouse Skin Tumor Promotion

(2010) Joyce E. Rundhaug et al.   Cancers

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

(2009) Shengyu Yang et al.   CANCER CELL

STIM1 Is a Calcium Sensor Specialized for Digital Signaling

(2009) Gary S. Bird et al.   CURRENT BIOLOGY

Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins

(2009) N. Scrimgeour et al.   JOURNAL OF PHYSIOLOGY-LONDON

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death

(2009) A. Berna-Erro et al.   Science Signaling

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Electrochemical Monitoring of Single Cell Secretion: Vesicular Exocytosis and Oxidative Stress

(2008) Christian Amatore et al.   CHEMICAL REVIEWS

Calcium signaling in lymphocytes

(2008) Masatsugu Oh-hora et al.   CURRENT OPINION IN IMMUNOLOGY

Epigenetic Changes Induced by Reactive Oxygen Species in Hepatocellular Carcinoma: Methylation of the E-cadherin Promoter

(2008) Seung-Oe Lim et al.   GASTROENTEROLOGY

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE

Co-evolution of tumor cells and their microenvironment

(2008) Kornelia Polyak et al.   TRENDS IN GENETICS