Article
Medicine, General & Internal
Yazun Jarrar, Ghasaq Abdul-Wahab, Rami Mosleh, Sara Abudahab, Qais Jarrar, Anas Hamdan, Shurouq Ghalib Qadous, Ruba Balasmeh, Abdulqader Fadhil Abed, Yasmeen Ibrahim, Amin A. Al-Doaiss, Mohammed Ali Alshehri
Summary: This study investigated the impact of Ramadan Intermittent Fasting (RIF) on fasting blood glucose (FBG) levels in diabetic patients and identified factors associated with variations in FBG levels during RIF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Food Science & Technology
Ruben Fernandez-Rodriguez, Vicente Martinez-Vizcaino, Arthur E. Mesas, Blanca Notario-Pacheco, Maria Medrano, Leonie K. Heilbronn
Summary: Intermittent fasting (IF) has positive effects on depression scores in the general population, but does not significantly affect anxiety or mood state.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biodiversity Conservation
Justin H. Baumann, Lily Z. Zhao, Adrian C. Stier, John F. Bruno
Summary: The study found that remote coral reefs are not necessarily more resilient to disturbances compared to reefs near human activities. Only drastic reductions in greenhouse gas emissions can ensure coral survival.
GLOBAL CHANGE BIOLOGY
(2022)
Article
Psychology, Multidisciplinary
Susana Carnero-Sierra, Julio Menor
Summary: Research has shown that false memories can be created through social contagion, without the physical presence of others, and there is no significant difference in the impact of false memories between young and older adults.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Nutrition & Dietetics
Xiao Tong Teong, Amy T. Hutchison, Bo Liu, Gary A. Wittert, Kylie Lange, Siobhan Banks, Leonie K. Heilbronn
Summary: Intermittent fasting (IF) and calorie restriction (CR) are both effective for weight loss, with IF showing greater reductions in weight and body fat. Both IF and CR resulted in improved cognitive performance, while having no significant impact on eating behaviors, mood, sleep quality, and quality of life.
NUTRITION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Xiaolong Tang, Guo Li, Lei Shi, Fengting Su, Minxian Qian, Zuojun Liu, Yuan Meng, Shimin Sun, Ji Li, Baohua Liu
Summary: The combination of intermittent fasting and chemotherapy can improve treatment efficacy, with the GSK3β-SIRT7 axis playing a crucial role. This mechanism is likely regulated by AMPK and GSK3β.
NATURE COMMUNICATIONS
(2021)
Article
Physiology
Elena M. Yee, Carson T. Hauser, Jonathan J. Petrocelli, Naomi M. M. P. de Hart, Patrick J. Ferrara, Princess Bombyck, Zachary J. Fennel, Lisha van Onselen, Sohom Mookerjee, Katsuhiko Funai, J. David Symons, Micah J. Drummond
Summary: This study found that 12 weeks of treadmill training in old male mice improved endothelial function, physical performance, and overall body composition, but had limited impact on skeletal muscle remodeling at baseline or in response to recovery following disuse atrophy.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giovanna De Cunto, Simone De Meo, Barbara Bartalesi, Eleonora Cavarra, Giuseppe Lungarella, Monica Lucattelli
Summary: Once COPD is established, pulmonary lesions continue to progress and smoking cessation alone cannot fully eliminate lung inflammation. Even in former-smoker mice, neutrophil inflammation persists and lung lesions worsen. This study investigates the molecular mechanisms underlying disease progression and the inefficacy of smoking cessation in resolving neutrophilic inflammation. It demonstrates reduced expression of HDAC2 and SIRT1 and increased expression of p-p38 MAPK and p-Ser10 in former-smoker mice, which are involved in corticosteroid insensitivity and perpetuating inflammation. The study suggests that targeting specific molecular mechanisms associated with different disease phenotypes may lead to better control of COPD in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Flaydson C. S. Pinto, Amanda A. M. Silva, Sandra L. Souza
Summary: This study provides a current survey of intermittent fasting (IF) protocols and their effects on the profile of the intestinal microbiota (IM) in obese organisms. It found that alternate-day fasting (ADF) and time-restricted feeding (TRF) are the most common protocols, and they have different mechanisms of metabolic signaling. Both protocols have the ability to remodel the IM and protect against the effects of weight gain.
Article
Microbiology
Troy C. Sutton, Elaine W. Lamirande, Devanshi R. Patel, Katherine E. E. Johnson, Rita Czako, Elodie Ghedin, Raphael T. C. Lee, Sebastian Maurer-Stroh, Kanta Subbarao
Summary: Through sequential rounds of airborne transmission experiments in ferrets, it has been confirmed that viruses infected through the respiratory route can continue to spread in ferrets, but the transmission efficiency varies depending on the virus strain. Emerging avian influenza viruses can also transmit between ferrets through sequential transmission.
Article
Cardiac & Cardiovascular Systems
Sasha Z. Prisco, Megan Eklund, Daphne M. Moutsoglou, Anthony R. Prisco, Alexander Khoruts, E. Kenneth Weir, Thenappan Thenappan, Kurt W. Prins
Summary: Intermittent fasting (IF) improves right ventricular function, increases survival rate, reduces cardiomyocyte hypertrophy and fibrosis, prevents lipid accumulation, and enhances gut microbiota profile in pulmonary arterial hypertension (PAH), suggesting it may be a non-pharmacological approach to combat RV dysfunction in PAH.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Felipe Kazmirczak, Lynn M. Hartweck, Neal T. Vogel, Jenna B. Mendelson, Anna K. Park, Rashmi M. Raveendran, Jin O-Uchi, Bong Sook Jhun, Sasha Z. Prisco, Kurt W. Prins
Summary: Intermittent fasting (IF) extends life span through pleotropic mechanisms, with adenosine monophosphate-activated protein kinase (AMPK) playing a crucial role. AMPK enhances lipid metabolism and modulates microtubule dynamics. Dysregulation of these pathways leads to right ventricular (RV) failure in pulmonary arterial hypertension patients. In rodent models of pulmonary arterial hypertension, IF activates RV AMPK, restoring mitochondrial and peroxisomal morphology and regulating lipid metabolism proteins. Additionally, IF increases electron transport chain protein levels and activity in the right ventricle. RV function measured by echocardiography and hemodynamics correlates positively with fatty acid oxidation and electron transport chain protein levels. IF also normalizes transverse tubule structure by reducing microtubule density.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Cell Biology
Yibing Nong, Yiru Guo, Anna Gumpert, Qianhong Li, Alex Tomlin, Xiaoping Zhu, Roberto Bolli
Summary: This study evaluated the efficacy of intramyocardial injection of synthetic microRNAs in a mouse model of reperfused myocardial infarction. The results showed that the injection of hsa-miR-199a-3p, hsa-miR-149-3p, or hsa-miR-149-5p mimic did not improve cardiac function or remodeling in this model. Rigorous preclinical studies are needed before considering clinical translation of this strategy.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Physiology
Nicholas T. Thomas, Amy L. Confides, Christopher S. Fry, Esther E. Dupont-Versteegden
Summary: Satellite cells are not required for diaphragm muscle adaptations to hypoxia in either adult or aged mice. Diaphragm muscle fibers consistently fuse with satellite cells throughout life, indicating a critical role of satellite cells in maintaining homeostasis. Consequently, a higher number of Pax3-positive cells in satellite cell-depleted diaphragm muscle may act as a compensatory mechanism.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Clinical Neurology
Nais Lira Soares, Victor Augusto Mathias Dorand, Hassler Clementino Cavalcante, Kamila Sabino Batista, Daniele Melo de Souza, Marcos Dos Santos Lima, Mirian Graciela da Silva Stiebbe Salvadori, Marciane Magnani, Adriano Francisco Alves, Jailane de Souza Aquino
Summary: IF and aerobic exercise, associated or not, can modulate parameters related to the gut-brain axis of Wistar rats, and some benefits may be related to the amounts of organic acids.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Cell & Tissue Engineering
Nicola Vannini, Vasco Campos, Mukul Girotra, Vincent Trachsel, Shanti Rojas-Sutterlin, Josefine Tratwal, Simone Ragusa, Evangelos Stefanidis, Dongryeol Ryu, Pernille Y. Rainer, Gena Nikitin, Sonja Giger, Terytty Y. Li, Aikaterini Semilietof, Aurelien Oggier, Yannick Yersin, Loic Tauzin, Eija Pirinen, Wan-Chen Cheng, Joanna Ratajczak, Carles Canto, Martin Ehrbar, Federico Sizzano, Tatiana V. Petrova, Dominique Vanhecke, Lianjun Zhang, Pedro Romero, Aimable Nahimana, Stephane Cherix, Michel A. Duchosal, Ping-Chih Ho, Bart Deplancke, George Coukos, Johan Auwerx, Matthias P. Lutolf, Olaia Naveiras
Article
Biochemistry & Molecular Biology
Maria Isabel Hernandez-Alvarez, David Sebastian, Sara Vives, Saska Ivanova, Paola Bartoccioni, Pamela Kakimoto, Natalia Plana, Sonia R. Veiga, Vanessa Hernandez, Nuno Vasconcelos, Gopal Peddinti, Anna Adrover, Mariona Jove, Reinald Pamplona, Isabel Gordaliza-Alaguero, Enrique Calvo, Noemi Cabre, Rui Castro, Antonija Kuzmanic, Marie Boutant, David Sala, Tuulia Hyotylainen, Matej Oresic, Joana Fort, Ekaitz Errasti-Murugarren, Cecilia M. P. Rodrigues, Modesto Orozco, Jorge Joven, Carles Canto, Manuel Palacin, Sonia Fernandez-Veledo, Joan Vendrell, Antonio Zorzano
Article
Nutrition & Dietetics
Yiin Ling, Jerome Carayol, Bogdan Galusca, Carles Canto, Christophe Montaurier, Alice Matone, Irene Vassallo, Kaori Minehira, Virginie Alexandre, Ornella Cominetti, Antonio Nunez Galindo, John Corthesy, Loic Dayon, Aline Charpagne, Sylviane Metairon, Frederic Raymond, Patrick Descombes, Francois Casteillo, Michel Peoc'h, Radu Palaghiu, Leonard Feasson, Yves Boirie, Bruno Estour, Jorg Hager, Natacha Germain, Nele Gheldof
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2019)
Article
Biochemistry & Molecular Biology
Caterina Collodet, Marc Foretz, Maria Deak, Laurent Bultot, Sylviane Metairon, Benoit Viollet, Gregory Lefebvre, Frederic Raymond, Alice Parisi, Gabriele Civiletto, Philipp Gut, Patrick Descombes, Kei Sakamoto
Article
Multidisciplinary Sciences
Audrey Sambeat, Joanna Ratajczak, Magali Joffraud, Jose L. Sanchez-Garcia, Maria P. Giner, Armand Valsesia, Judith Giroud-Gerbetant, Miriam Valera-Alberni, Angelique Cercillieux, Marie Boutant, Sameer S. Kulkarni, Sofia Moco, Caries Canto
NATURE COMMUNICATIONS
(2019)
Article
Pediatrics
Remi Doucet-Ladeveze, Sebastien Holvoet, Frederic Raymond, Francis Foata, Gurjit K. Khurana Hershey, Joseph D. Sherrill, Marc E. Rothenberg, Carine Blanchard
FRONTIERS IN PEDIATRICS
(2019)
Article
Multidisciplinary Sciences
Eugenia Migliavacca, Stacey K. H. Tay, Harnish P. Patel, Tanja Sonntag, Gabriele Civiletto, Craig McFarlane, Terence Forrester, Sheila J. Barton, Melvin K. Leow, Elie Antoun, Aline Charpagne, Yap Seng Chong, Patrick Descombes, Lei Feng, Patrice Francis-Emmanuel, Emma S. Garratt, Maria Pilar Giner, Curtis O. Green, Sonia Karaz, Narasimhan Kothandaraman, Julien Marquis, Sylviane Metairon, Sofia Moco, Gail Nelson, Sherry Ngo, Tony Pleasants, Frederic Raymond, Avan A. Sayer, Chu Ming Sim, Jo Slater-Jefferies, Holly E. Syddall, Pei Fang Tan, Philip Titcombe, Candida Vaz, Leo D. Westbury, Gerard Wong, Wu Yonghui, Cyrus Cooper, Allan Sheppard, Keith M. Godfrey, Karen A. Lillycrop, Neerja Karnani, Jerome N. Feige
NATURE COMMUNICATIONS
(2019)
Article
Endocrinology & Metabolism
Judith Giroud-Gerbetant, Magali Joffraud, Maria Pilar Giner, Angelique Cercillieux, Simona Bartova, Mikhail Makarov, Ruben Zapata-Perez, Jose L. Sanchez-Garcia, Riekelt H. Houtkooper, Marie E. Migaud, Sofia Moco, Carles Canto
MOLECULAR METABOLISM
(2019)
Article
Biology
Marco Sazzini, Paolo Abondio, Stefania Sarno, Guido Alberto Gnecchi-Ruscone, Matteo Ragno, Cristina Giuliani, Sara De Fanti, Claudia Ojeda-Granados, Alessio Boattini, Julien Marquis, Armand Valsesia, Jerome Carayol, Frederic Raymond, Chiara Pirazzini, Elena Marasco, Alberto Ferrarini, Luciano Xumerle, Sebastiano Collino, Daniela Mari, Beatrice Arosio, Daniela Monti, Giuseppe Passarino, Patrizia D'Aquila, Davide Pettener, Donata Luiselli, Gastone Castellani, Massimo Delledonne, Patrick Descombes, Claudio Franceschi, Paolo Garagnani
Article
Biochemistry & Molecular Biology
Ruben Zapata-Perez, Alessandra Tammaro, Bauke V. Schomakers, Angelique M. L. Scantlebery, Simone Denis, Hyung L. Elfrink, Judith Giroud-Gerbetant, Carles Canto, Carmen Lopez-Leonardo, Rebecca L. McIntyre, Michel van Weeghel, Alvaro Sanchez-Ferrer, Riekelt H. Houtkooper
Summary: NMNH, as a new NAD(+) precursor, significantly increases NAD(+) levels and reduces damage through a unique metabolic pathway. Administration of NMNH in mice leads to a rapid surge in NAD(+) levels, demonstrating its potential for treating acute kidney injury.
Article
Biology
Paolo Garagnani, Julien Marquis, Massimo Delledonne, Chiara Pirazzini, Elena Marasco, Katarzyna Malgorzata Kwiatkowska, Vincenzo Iannuzzi, Maria Giulia Bacalini, Armand Valsesia, Jerome Carayol, Frederic Raymond, Alberto Ferrarini, Luciano Xumerle, Sebastiano Collino, Daniela Mari, Beatrice Arosio, Martina Casati, Evelyn Ferri, Daniela Monti, Benedetta Nacmias, Sandro Sorbi, Donata Luiselli, Davide Pettener, Gastone Castellani, Claudia Sala, Giuseppe Passarino, Francesco De Rango, Patrizia D'Aquila, Luca Bertamini, Nicola Martinelli, Domenico Girelli, Oliviero Olivieri, Cristina Giuliani, Patrick Descombes, Claudio Franceschi
Summary: People who reach extreme ages have a unique genetic background associated with efficient DNA repair mechanisms, which helps delay aging and protect from cardiovascular events. This genetic trait is characterized by lower mutation load compared to younger individuals, as shown in both germline and somatic mutation patterns.
Article
Nutrition & Dietetics
Frederic Raymond, Gregory Lefebvre, Lorane Texari, Solenn Pruvost, Sylviane Metairon, Geoffrey Cottenet, Alix Zollinger, Bogdan Mateescu, Claude Billeaud, Jean-Charles Picaud, Irma Silva-Zolezzi, Patrick Descombes, Nabil Bosco
Summary: This study characterized the longitudinal profile of miRNAs in human milk between the second week and the third month postpartum. The study detected 685 miRNAs, of which 35 showed a high and stable expression along the lactation period analyzed. Additionally, a set of 11 miRNAs with a dynamic expression profile was described for the first time. In vitro experiments also provided support for the hypothesized mother-to-neonate signaling role of human milk miRNAs.
JOURNAL OF NUTRITION
(2022)
Article
Cell Biology
Miriam Valera-Alberni, Magali Joffraud, Joan Miro-Blanch, Jordi Capellades, Alexandra Junza, Loic Dayon, Antonio Nunez Galindo, Jose L. Sanchez-Garcia, Armand Valsesia, Angelique Cercillieux, Flavia Soellner, Andreas G. Ladurner, Oscar Yanes, Carles Canto
Summary: This study demonstrates the regulation of mitochondrial dynamics through the phosphorylation of Drp1 at the S579 and S600 sites, and its impact on mitochondrial remodeling, metabolic function, and glucose tolerance. The findings suggest an interplay between the phosphorylation sites of Drp1, which can modulate lipid oxidation, respiratory capacity, and thermogenic response. The results provide evidence for the potential use of Drp1 phosphorylation modulation in the treatment and prevention of metabolic diseases.
Review
Biochemistry & Molecular Biology
Angelique Cercillieux, Eleonora Ciarlo, Carles Canto
Summary: This review discusses alterations in cellular NAD(+) levels and the potential health benefits of dietary supplementation with NAD(+) precursors, particularly Nicotinamide Riboside (NR). While NR has shown success in pre-clinical studies, clinical outcomes have not met expectations. The review explores the biology of NAD(+), causes of NAD(+) deficits, and the journey of NR from discovery to clinical development. It also addresses the limitations of NR-based therapies and potential solutions. The review provides tools to understand NAD(+) biology and assess its changes in disease situations, as well as determine the most promising NAD(+) precursor for therapeutic use.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Elena Lo Piparo, Lydia Siragusa, Frederic Raymond, Giovanna Ilaria Passeri, Gabriele Cruciani, Benoit Schilter
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2020)