Differential Aggregation and Phosphorylation of Alpha Synuclein in Membrane Compartments Associated With Parkinson Disease

Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?

(2018) Kurt A. Jellinger et al.   BMC Medicine

Extracellular α-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G-protein signaling

(2018) Shaymaa Mohamed Mohamed Badawy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

“Lipid raft aging” in the human frontal cortex during nonpathological aging: gender influences and potential implications in Alzheimer's disease

(2018) Mario Díaz et al.   NEUROBIOLOGY OF AGING

Estrogen Interactions With Lipid Rafts Related to Neuroprotection. Impact of Brain Ageing and Menopause

(2018) Raquel Marin et al.   Frontiers in Neuroscience

Import and Export of Misfolded α-Synuclein

(2018) Lilia Rodriguez et al.   Frontiers in Neuroscience

Ganglioside lipids accelerate α-synuclein amyloid formation

(2018) Ricardo Gaspar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Biophysical Alterations in Lipid Rafts from Human Cerebral Cortex Associate with Increased BACE1/AβPP Interaction in Early Stages of Alzheimer's Disease

(2018) Mario Díaz et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid oligomerization of the Parkinson's disease related protein α-synuclein impacts on its curvature-membrane sensitivity

(2018) J. Ignacio Gallea et al.   JOURNAL OF NEUROCHEMISTRY

Dementia with Lewy bodies and Parkinson’s disease-dementia: current concepts and controversies

(2017) Kurt A. Jellinger   JOURNAL OF NEURAL TRANSMISSION

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

(2017) Diana G Ferreira et al.   NATURE NEUROSCIENCE

Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in dementia with Lewy bodies disclose neurochemical traits partially shared by Alzheimer's and Parkinson's diseases

(2017) Raquel Marin et al.   NEUROBIOLOGY OF AGING

Lipid Alterations in Lipid Rafts from Alzheimer's Disease Human Brain Cortex

(2017) Virginia Martín et al.   JOURNAL OF ALZHEIMERS DISEASE

Prion Protein is Reduced in Aging and in Sporadic but not in Familial Alzheimer's Disease

(2017) Isobel J. Whitehouse et al.   JOURNAL OF ALZHEIMERS DISEASE

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

Protein Partners of α-Synuclein in Health and Disease

(2016) Louise Berkhoudt Lassen et al.   BRAIN PATHOLOGY

Lipid Raft Alterations in Aged-Associated Neuropathologies

(2016) Raquel Marin et al.   Current Alzheimer Research

New insights into cellular α-synuclein homeostasis in health and disease

(2016) Ulf Dettmer et al.   CURRENT OPINION IN NEUROBIOLOGY

Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson's disease

(2016) Margaux Doria et al.   FREE RADICAL BIOLOGY AND MEDICINE

Membrane Binding of Parkinson's Protein α-Synuclein: Effect of Phosphorylation at Positions 87 and 129 by the S to D Mutation Approach

(2016) Pravin Kumar et al.   ISRAEL JOURNAL OF CHEMISTRY

Gangliosides of the Vertebrate Nervous System

(2016) Ronald L. Schnaar   JOURNAL OF MOLECULAR BIOLOGY

Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders

(2016) Xuling Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease

(2016) Matthew J. Benskey et al.   JOURNAL OF NEUROCHEMISTRY

Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers

(2016) Cathryn L. Ugalde et al.   JOURNAL OF NEUROCHEMISTRY

Dynamic structural flexibility of α-synuclein

(2016) Danielle E. Mor et al.   NEUROBIOLOGY OF DISEASE

Key Points Concerning Amyloid Infectivity and Prion-Like Neuronal Invasion

(2016) Alba Espargaró et al.   Frontiers in Molecular Neuroscience

The Prion Hypothesis of Parkinson’s Disease

(2015) Yaping Chu et al.   Current Neurology and Neuroscience Reports

Lipid rafts involvement in the pathogenesis of Parkinson s disease

(2015) Shin-ichiro Kubo   Frontiers in Bioscience-Landmark

Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization

(2015) Filsy Samuel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies

(2015) Anna Villar-Piqué et al.   JOURNAL OF NEUROCHEMISTRY

The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease

(2015) Yan Xu et al.   JOURNAL OF NEUROCHEMISTRY

Definition of a Molecular Pathway Mediating  -Synuclein Neurotoxicity

(2015) J. Burre et al.   JOURNAL OF NEUROSCIENCE

Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein

(2015) Johannes C.M. Schlachetzki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Cholesterol – A putative endogenous contributor towards Parkinson's disease

(2015) Rajib Paul et al.   NEUROCHEMISTRY INTERNATIONAL

Alpha-synuclein modulates NR2B-containing NMDA receptors and decreases their levels after rotenone exposure

(2015) Laura Navarria et al.   NEUROCHEMISTRY INTERNATIONAL

α-Synuclein-induced internalization of NMDA receptors in hippocampal neurons is associated with reduced inward current and Ca2+ influx upon NMDA stimulation

(2015) Y. Chen et al.   NEUROSCIENCE

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

Couldα-Synuclein Amyloid-Like Aggregates Trigger a Prionic Neuronal Invasion?

(2015) Maria Antònia Busquets et al.   Biomed Research International

Distribution of C16:0, C18:0, C24:1, and C24:0 sulfatides in central nervous system lipid rafts by quantitative ultra-high-pressure liquid chromatography tandem mass spectrometry

(2014) Ana Lis Moyano et al.   ANALYTICAL BIOCHEMISTRY

Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity

(2014) Eric S. Luth et al.   BIOCHEMISTRY

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

(2014) Edward Rockenstein et al.   BRAIN

GSK-3β dysregulation contributes to parkinson’s-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein

(2014) J J Credle et al.   CELL DEATH AND DIFFERENTIATION

Evidence of Native α-Synuclein Conformers in the Human Brain

(2014) Neal Gould et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenic role of ganglioside metabolism in neurodegenerative diseases

(2014) Toshio Ariga   JOURNAL OF NEUROSCIENCE RESEARCH

Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions

(2014) Noemí Fabelo et al.   NEUROBIOLOGY OF AGING

Role of Lipid Rafts and GM1 in the Segregation and Processing of Prion Protein

(2014) Laura Botto et al.   PLoS One

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity

(2013) Robert H. C. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synucleinopathy phenotypes

(2013) Heather McCann et al.   PARKINSONISM & RELATED DISORDERS

Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra

(2013) Lin Gao et al.   PLoS One

Prion Protein Accumulation in Lipid Rafts of Mouse Aging Brain

(2013) Federica Agostini et al.   PLoS One

Membrane Lipid Co-Aggregation with α-Synuclein Fibrils

(2013) Erik Hellstrand et al.   PLoS One

Evidence for Premature Lipid Raft Aging in APP/PS1 Double-Transgenic Mice, a Model of Familial Alzheimer Disease

(2012) Noemí Fabelo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer’s disease

(2011) Andrey Y. Abramov et al.   AGING CELL

α-Synuclein misfolding and Parkinson's disease

(2011) Leonid Breydo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Deciphering the Molecular Details for the Binding of the Prion Protein to Main Ganglioside GM1 of Neuronal Membranes

(2011) Narinder Sanghera et al.   CHEMISTRY & BIOLOGY

Toxic effects of amyloid fibrils on cell membranes: the importance of ganglioside GM1

(2011) Monica Bucciantini et al.   FASEB JOURNAL

Structural and Morphological Characterization of Aggregated Species of α-Synuclein Induced by Docosahexaenoic Acid

(2011) Giorgia De Franceschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein promotes clathrin-mediated NMDA receptor endocytosis and attenuates NMDA-induced dopaminergic cell death

(2011) Furong Cheng et al.   JOURNAL OF NEUROCHEMISTRY

Transmission of Prion Strains in a Transgenic Mouse Model Overexpressing Human A53T Mutated α-Synuclein

(2011) Anne-Laure J. Mougenot et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

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(2011) Noemi Fabelo et al.   MOLECULAR MEDICINE

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Lipid rafts: Keys to neurodegeneration

(2010) Cara-Lynne Schengrund   BRAIN RESEARCH BULLETIN

Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases

(2010) R. Morales et al.   JOURNAL OF NEUROSCIENCE

The behavior of α-synuclein in neurons

(2010) Doris L. Fortin et al.   MOVEMENT DISORDERS

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Molecular Insights into the Interaction between α-Synuclein and Docosahexaenoic Acid

(2009) Giorgia De Franceschi et al.   JOURNAL OF MOLECULAR BIOLOGY

α-Synuclein Selectively Binds to Anionic Phospholipids Embedded in Liquid-Disordered Domains

(2007) Martin Stöckl et al.   JOURNAL OF MOLECULAR BIOLOGY