Small‐molecule‐mediated chemical knock‐down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure

Loss of Sox9 in cardiomyocytes delays the onset of cardiac hypertrophy and fibrosis

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Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy

(2018) Mitsutaka Yakabe et al.   PLoS One

Prolonged mechanical ventilation worsens sepsis-induced diaphragmatic dysfunction in the rat

(2018) Matthieu Le Dinh et al.   PLoS One

High-intensity interval training prevents oxidant-mediated diaphragm muscle weakness in hypertensive mice

(2017) T. Scott Bowen et al.   FASEB JOURNAL

Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia

(2017) Thomas Scott Bowen et al.   Journal of Cachexia Sarcopenia and Muscle

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(2017) Cécile Polge et al.   Journal of Cachexia Sarcopenia and Muscle

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(2017) Stephan von Haehling et al.   Journal of Cachexia Sarcopenia and Muscle

Pharmacological targeting of mitochondrial reactive oxygen species counteracts diaphragm weakness in chronic heart failure

(2016) Orlando Laitano et al.   JOURNAL OF APPLIED PHYSIOLOGY

Exercise Training Prevents Diaphragm Contractile Dysfunction in Heart Failure

(2016) NORMAN MANGNER et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients

(2015) Pleuni E. Hooijman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle

(2015) T. Scott Bowen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Diaphragm muscle weakness in mice is early-onset post-myocardial infarction and associated with elevated protein oxidation

(2015) T. Scott Bowen et al.   JOURNAL OF APPLIED PHYSIOLOGY

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(2015) Shenhav Cohen et al.   NATURE REVIEWS DRUG DISCOVERY

Skeletal muscle alterations in chronic heart failure: differential effects on quadriceps and diaphragm

(2015) Norman Mangner et al.   Journal of Cachexia Sarcopenia and Muscle

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(2015) T. Scott Bowen et al.   Journal of Cachexia Sarcopenia and Muscle

Inhibition of the Ubiquitin–Proteasome Pathway Does Not Protect against Ventilator-induced Accelerated Proteolysis or Atrophy in the Diaphragm

(2014) Ashley J. Smuder et al.   ANESTHESIOLOGY

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Mitochondrial reactive oxygen species production and respiratory complex activity in rats with pressure overload-induced heart failure

(2014) Michael Schwarzer et al.   JOURNAL OF PHYSIOLOGY-LONDON

β–Hydroxy β–Methylbutyrate Improves Dexamethasone-Induced Muscle Atrophy by Modulating the Muscle Degradation Pathway in SD Rat

(2014) Kyung Kyun Noh et al.   PLoS One

Diaphragm Dysfunction on Admission to the Intensive Care Unit. Prevalence, Risk Factors, and Prognostic Impact—A Prospective Study

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Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome

(2013) Marco Sandri   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MG132-mediated inhibition of the ubiquitin–proteasome pathway ameliorates cancer cachexia

(2013) Liuping Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index

(2013) Lisa Martin et al.   JOURNAL OF CLINICAL ONCOLOGY

Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes

(2013) Estibaliz Castillero et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Diaphragm Atrophy and Contractile Dysfunction in a Murine Model of Pulmonary Hypertension

(2013) Bumsoo Ahn et al.   PLoS One

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Exercise Training Attenuates MuRF-1 Expression in the Skeletal Muscle of Patients With Chronic Heart Failure Independent of Age

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Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF)

(2012) S. Fulster et al.   EUROPEAN HEART JOURNAL

Titin and diaphragm dysfunction in mechanically ventilated rats

(2012) Hieronymus W. H. van Hees et al.   INTENSIVE CARE MEDICINE

Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4-week hindlimb unloading

(2012) Jing Liu et al.   IUBMB LIFE

Mitochondrial biogenesis and fragmentation as regulators of protein degradation in striated muscles

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The proteasome inhibitor MG132 reduces immobilization-induced skeletal muscle atrophy in mice

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Targeting the Ubiquitin E3 Ligase MuRF1 to Inhibit Muscle Atrophy

(2011) Michael J. Eddins et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

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Increased Proteolysis, Myosin Depletion, and Atrophic AKT-FOXO Signaling in Human Diaphragm Disuse

(2010) Sanford Levine et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heart failure increases atrogin-1 and MuRF1 gene expression in skeletal muscle with fiber type-specific atrophy

(2010) Robson Francisco Carvalho et al.   JOURNAL OF MOLECULAR HISTOLOGY

Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction

(2009) G. S. Supinski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

(2009) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

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(2009) Paul J Boersema et al.   Nature Protocols

MuRF1-dependent Regulation of Systemic Carbohydrate Metabolism as Revealed from Transgenic Mouse Studies

(2008) Stephanie Hirner et al.   JOURNAL OF MOLECULAR BIOLOGY

Induction of MuRF1 Is Essential for TNF-α-Induced Loss of Muscle Function in Mice

(2008) Volker Adams et al.   JOURNAL OF MOLECULAR BIOLOGY

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(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY