A multiscale model of epigenetic heterogeneity-driven cell fate decision-making

A stochastic and dynamical view of pluripotency in mouse embryonic stem cells

(2018) Yen Ting Lin et al.   PLoS Computational Biology

Epigenetic regulation of cell fate reprogramming in aging and disease: A predictive computational model

(2018) Núria Folguera-Blasco et al.   PLoS Computational Biology

Turning back time with emerging rejuvenation strategies

(2018) Salah Mahmoudi et al.   NATURE CELL BIOLOGY

Mean first passage times for piecewise deterministic Markov processes and the effects of critical points

(2017) Paul C Bressloff et al.   JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT

Stochastic models of gene transcription with upstream drives: exact solution and sample path characterization

(2017) Justine Dattani et al.   Journal of the Royal Society Interface

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

The Fountain of Youth by Targeting Senescent Cells?

(2017) Peter L.J. de Keizer   TRENDS IN MOLECULAR MEDICINE

Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells

(2017) Stefan Semrau et al.   Nature Communications

Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis

(2017) Rosa M. Marión et al.   Stem Cell Reports

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Achieving diverse and monoallelic olfactory receptor selection through dual-objective optimization design

(2016) Xiao-Jun Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The physics of epigenetics

(2016) Ruggero Cortini et al.   REVIEWS OF MODERN PHYSICS

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

(2016) Lluc Mosteiro et al.   SCIENCE

Dynamics of epigenetic regulation at the single-cell level

(2016) L. Bintu et al.   SCIENCE

Anti-Aging Strategies Based on Cellular Reprogramming

(2016) Alejandro Ocampo et al.   TRENDS IN MOLECULAR MEDICINE

Intrinsic Noise Profoundly Alters the Dynamics and Steady State of Morphogen-Controlled Bistable Genetic Switches

(2016) Ruben Perez-Carrasco et al.   PLoS Computational Biology

Oncometabolic Nuclear Reprogramming of Cancer Stemness

(2016) Javier A. Menendez et al.   Stem Cell Reports

Epigenetics and aging

(2016) S. Pal et al.   Science Advances

Epigenetic predisposition to reprogramming fates in somatic cells

(2015) M. Pour et al.   EMBO REPORTS

The effects of intrinsic noise on the behaviour of bistable cell regulatory systems under quasi-steady state conditions

(2015) Roberto de la Cruz et al.   JOURNAL OF CHEMICAL PHYSICS

Stochastic Phenotype Transition of a Single Cell in an Intermediate Region of Gene State Switching

(2015) Hao Ge et al.   PHYSICAL REVIEW LETTERS

Central limit theorems and diffusion approximations for multiscale Markov chain models

(2014) Hye-Won Kang et al.   ANNALS OF APPLIED PROBABILITY

Dedifferentiation and reprogramming: origins of cancer stem cells

(2014) D. Friedmann-Morvinski et al.   EMBO REPORTS

Stochastic quasi-steady state approximations for asymptotic solutions of the chemical master equation

(2014) Tomás Alarcón   JOURNAL OF CHEMICAL PHYSICS

Path integrals and large deviations in stochastic hybrid systems

(2014) Paul C. Bressloff et al.   PHYSICAL REVIEW E

Stem cell differentiation as a many-body problem

(2014) B. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypic switching in gene regulatory networks

(2014) P. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Separation of time-scales and model reduction for stochastic reaction networks

(2013) Hye-Won Kang et al.   ANNALS OF APPLIED PROBABILITY

Cellular Compartments Cause Multistability and Allow Cells to Process More Information

(2013) Heather A. Harrington et al.   BIOPHYSICAL JOURNAL

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

(2013) María Abad et al.   NATURE

On the role of lateral stabilization during early patterning in the pancreas

(2012) W. de Back et al.   Journal of the Royal Society Interface

A Simple Histone Code Opens Many Paths to Epigenetics

(2012) Kim Sneppen et al.   PLoS Computational Biology

Reprogramming cell fates: reconciling rarity with robustness

(2009) Sui Huang   BIOESSAYS

Inheritance of epigenetic chromatin silencing

(2009) Diana David-Rus et al.   JOURNAL OF THEORETICAL BIOLOGY

The large deviation approach to statistical mechanics

(2009) Hugo Touchette   PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS

Approximate Bayesian computation scheme for parameter inference and model selection in dynamical systems

(2008) T. Toni et al.   Journal of the Royal Society Interface

Neutralism and selectionism: a network-based reconciliation

(2008) Andreas Wagner   NATURE REVIEWS GENETICS

Multistable Decision Switches for Flexible Control of Epigenetic Differentiation

(2008) Raúl Guantes et al.   PLoS Computational Biology

Robustness and evolvability: a paradox resolved

(2007) A. Wagner   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES